Search Results - "Andrus, Merritt"

Human skin gene expression: Natural (trans) resveratrol versus five resveratrol analogs for dermal applications by Lephart, Edwin D, Andrus, Merritt B

“…Resveratrol (RV) is a polyphenolic compound naturally produced by plants. Polyphenolic compounds incorporated into medicinal products are beneficial but, RV is…”
Get full text

Intramolecular Heteroatom and Styryl Diels–Alder Reactions, Asymmetric Cycloadditions of Chiral 3‑Phenylallyl Maleic Esters by Mpaata, Peter, Miller, Chandler R., Bonsrah, Dickson K., Camp, Alexander B., Ballard, Karson M., Angelie, Liahona, Kirkland, Justin, Joy, Jyothish, Hirschi, William J., Smith, Stacey J., Ess, Daniel H., Andrus, Merritt B.

“…Polycyclic aryl naphthalene and tetralin dihydro arylnaphthalene lactone lignans possess anticancer and antibiotic activity. Related furo­[3,4-c]­pyranones,…”
Get full text

Quantum Mechanical Transition-State Analysis Reveals the Precise Origin of Stereoselectivity in Chiral Quaternary Cinchonidinium Phase-Transfer Catalyzed Enolate Allylation by Cook, Thomas C, Andrus, Merritt B, Ess, Daniel H

“…Density functional theory was used to model glycinate enolate binding and enantiomeric allylation transition states mediated by the cinchonidinium…”
Get full text

Synthesis and Computational Studies Demonstrate the Utility of an Intramolecular Styryl Diels–Alder Reaction and Di‑t‑butylhydroxytoluene Assisted [1,3]-Shift to Construct Anticancer dl-Deoxypodophyllotoxin by Saavedra, Diana I, Rencher, Benjamin D, Kwon, Doo-Hyun, Smith, Stacey J, Ess, Daniel H, Andrus, Merritt B

“…Deoxypodophyllotoxin is a secondary metabolite lignan possessing potent anticancer activity with potential as a precursor for known anticancer drugs, but its…”
Get full text

The Effects of 4'-Esterified Resveratrol Derivatives on Calcium Dynamics in Breast Cancer Cells by Peterson, Joshua A, Doughty, Hayden P, Eells, Austin J, Johnson, Trent A, Hastings, Jordan P, Crowther, Colton M, Andrus, Merritt B, Kenealey, Jason D

“…Triple-negative breast cancer is a highly aggressive subtype of breast cancer. Frequently, breast cancer cells modulate their calcium signaling pathways to…”
Get full text

Selective esterification of the polyphenol resveratrol at the 4′-position by Acerson, Mark J., Andrus, Merritt B.

“…•The polyphenol resveratrol was selectively acylated at the 4′-position using simple reagents.•Various 4′-esters of resveratrol are now available in moderate…”
Get full text

Resveratrol derivatives increase cytosolic calcium by inhibiting plasma membrane ATPase and inducing calcium release from the endoplasmic reticulum in prostate cancer cells by Peterson, Joshua A, Crowther, Colton M, Andrus, Merritt B, Kenealey, Jason D

“…Resveratrol (RES) is a putative chemotherapeutic naturally found in grapes, peanuts, and Japanese knotweed. Previous studies demonstrate that RES modulates…”
Get full text

Synthesis and skin gene analysis of 4′-acetoxy-resveratrol (4AR), therapeutic potential for dermal applications by Lephart, Edwin D., Acerson, Mark J., Andrus, Merritt B.

“…[Display omitted] Resveratrol (RV) 1, a plant polyphenol, has proven effective in commercial products yet drawbacks include low bioavailability due to rapid…”
Get full text

Asymmetric Addition of Aryl Boron Reagents to Enones with Rhodium Dicyclophane Imidazolium Carbene Catalysis by Ma, Yudao, Song, Chun, Ma, Changqing, Sun, Zhijun, Chai, Qiang, Andrus, Merritt B.

“…Chiral N‐heterocyclic carbene ligands based on [2.2]paracyclophanes form complexes with rhodium. These catalysts can be used in the high‐yielding and…”
Get full text

Highly Enantioselective Copper−Bisoxazoline-Catalyzed Allylic Oxidation of Cyclic Olefins with tert-Butyl p-nitroperbenzoate by Andrus, Merritt B, Zhou, Ziniu

“…Catalytic asymmetric allylic oxidation of cyclic olefins ocurrs for the first time in very high (94−99% ee) enantioselectivity using copper(I) complexes of…”
Get full text

Palladium−Imidazolium Carbene Catalyzed Aryl, Vinyl, and Alkyl Suzuki−Miyaura Cross Coupling by Andrus, Merritt B, Song, Chun

“…N,N-Bis-(2,6-diisopropylphenyl)dihydroimidazolium chloride with palladium(II) acetate (2 mol %) was used as catalyst, without added base, to efficiently cross…”
Get full text

Naphthyl-substituted bisoxazoline and pyridylbisoxazoline–copper(I) catalysts for asymmetric allylic oxidation by Zhou, Ziniu, Andrus, Merritt B.

“…The synthesis of naphthyl substituted malonyl-derived and pyridine-based bisoxazolines and their applications in the asymmetric allylic oxidation of…”
Get full text

Palladium−Imidazolium Carbene Catalyzed Mizoroki−Heck Coupling with Aryl Diazonium Ions by Andrus, Merritt B, Song, Chun, Zhang, Jiuqing

“…Catalyst formed from N,N-bis(2,6-diisopropylphenyl)dihydroimidazolium chloride and palladium(II) acetate (2 mol %) was used, without added base, to efficiently…”
Get full text

A new synthesis of 4′-resveratrol esters and evaluation of the potential for anti-depressant activity by Acerson, Mark J., Fabick, Kimberly M., Wong, Yong, Blake, Crystal, Lephart, Edwin D., Andrus, Merritt B.

“…The 4′-ester analog of the disease preventative resveratrol 1 (RV), 4′-acetyl-RV 2 along with 4′-pivaloate 13 and benzoate 14 RV were synthesized. The…”
Get full text

Total Synthesis of the Hydroxyketone Kurasoin A Using Asymmetric Phase-Transfer Alkylation by Andrus, Merritt B, Hicken, Erik J, Stephens, Jeffrey C, Bedke, D. Karl

“…The total synthesis of the farnesyltransferase inhibitor kurasoin A has been achieved using a novel asymmetric phase-transfer-catalyzed glycolate alkylation…”
Get full text

Isolation and identification of compounds from Kalanchoe pinnata having human alphaherpesvirus and vaccinia virus antiviral activity by Cryer, Matthew, Lane, Kyle, Greer, Mary, Cates, Rex, Burt, Scott, Andrus, Merritt, Zou, Jiping, Rogers, Paul, Hansen, Marc D. H., Burgado, Jillybeth, Satheshkumar, Panayampalli Subbian, Day, Craig W., Smee, Donald F., Johnson, F. Brent

“…Context: Kalanchoe pinnata (Lam.) Pers. (Crassulaceae) is a succulent plant that is known for its traditional antivirus and antibacterial usage. Objective:…”
Get full text

Resveratrol: influences on gene expression in human skin by Lephart, Edwin D., Sommerfeldt, John M., Andrus, Merritt B.

“…•Natural resveratrol was examined via gene array technology in human skin.•Dermal biomarkers were quantified via qPRC experiments.•Resveratrol increased SIRT…”
Get full text

Synthesis of 4′-ester analogs of resveratrol and their evaluation in malignant melanoma and pancreatic cell lines by Wong, Yong, Osmond, Gregory, Brewer, Kenneth I., Tyler, Douglas S., Andrus, Merritt B.

“…4′-Ester analogs of the disease preventative agent resveratrol were synthesized and evaluated for their potential as anti-melanoma and pancreatic cancer…”
Get full text

Borylation of Aryldiazonium Ions with N-Heterocyclic Carbene−Palladium Catalysts Formed without Added Base by Ma, Yudao, Song, Chun, Jiang, Wei, Xue, Guoping, Cannon, John F, Wang, Xiaomei, Andrus, Merritt B

“…A highly efficient catalytic borylation process with aryldiazonium ions was developed using a carbene−palladium catalyst formed in situ to give…”
Get full text

Total Synthesis of (+)-Geldanamycin and (−)-o-Quinogeldanamycin:  Asymmetric Glycolate Aldol Reactions and Biological Evaluation by Andrus, Merritt B, Meredith, Erik L, Hicken, Erik J, Simmons, Bryon L, Glancey, Russell R, Ma, Wei

“…The total synthesis of (+)-geldanamycin (GA), following a linear route, has been completed using a demethylative quinone-forming reaction as the last step. Key…”
Get full text