Search Results - "Androulakis, I.P"

Analysis of time-series gene expression data: methods, challenges, and opportunities by Androulakis, I P, Yang, E, Almon, R R

“…Monitoring the change in expression patterns over time provides the distinct possibility of unraveling the mechanistic drivers characterizing cellular…”
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A multiscale model for the assessment of autonomic dysfunction in human endotoxemia by Foteinou, P.T, Calvano, S.E, Lowry, S.F, Androulakis, I.P

“…[...]a signal transduction model is developed to describe the release of stress hormones, whereas disruptions in autonomic activity are quantified through HRV…”
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Global optimization of MINLP problems in process synthesis and design by Adjiman, C.S., Androulakis, I.P., Floudas, C.A.

“…Two new methodologies for the global optimization of MINLP models, the Special structure Mixed Integer Nonlinear αBB, SMIN-αBB, and the General structure Mixed…”
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Solving long-term financial planning problems via global optimization by Maranas, C.D., Androulakis, I.P., Floudas, C.A., Berger, A.J., Mulvey, J.M.

“…A significant multi-stage financial planning problem is posed as a stochastic program with decision rules. The decision rule — called dynamically balanced —…”
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Approaches to asynchronous decentralized decision making by Androulakis, I.P., Reklaitis, G.V.

“…Motivated by the ideas of asynchronous relaxation algorithms this paper investigates optimal decision-making problems that exhibit decentralized…”
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Role of distributed oxygen addition and product removal in the oxidative coupling of methane by Androulakis, Ioannis P., Reyes, Sebastián C.

“…Modeling and optimization of C2 hydrocarbon production via the oxidative coupling of methane (OCM) were studied. The model includes both homogeneous and…”
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Systems Biology of Circadian-Immune Interactions by Mavroudis, P.D., Scheff, J.D., Calvano, S.E., Androulakis, I.P.

“…There is increasing evidence that the immune system is regulated by circadian rhythms. A wide range of immune parameters, such as the number of red blood cells…”
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Modeling endotoxin-induced systemic inflammation using an indirect response approach by Foteinou, P.T., Calvano, S.E., Lowry, S.F., Androulakis, I.P.

“…A receptor mediated model of endotoxin-induced human inflammation is proposed. The activation of the innate immune system in response to the endotoxin stimulus…”
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Molecular mechanisms of chronic intermittent hypoxia and hypertension by Sunderram, Jag, Androulakis, Ioannis P

“…Obstructive sleep apnea (OSA) is characterized by episodes of repeated airway obstruction resulting in cessation (apnea) or reduction (hypopnea) in airflow…”
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Networks, biology and systems engineering: A case study in inflammation by Foteinou, P.T., Yang, E., Androulakis, I.P.

“…Biological systems can be modeled as networks of interacting components across multiple scales. A central problem in computational systems biology is to…”
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Global optimization of mixed-integer nonlinear problems by Adjiman, C. S., Androulakis, I. P., Floudas, C. A.

“…Two novel deterministic global optimization algorithms for nonconvex mixed‐integer problems (MINLPs) are proposed, using the advances of the αBB algorithm for…”
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A global optimization method, αBB, for general twice-differentiable constrained NLPs—II. Implementation and computational results by Adjiman, C.S., Androulakis, I.P., Floudas, C.A.

“…Part I of this paper ( Adjiman et al., 1998a) described the theoretical foundations of a global optimization algorithm, the αBB algorithm, which can be used to…”
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Kinetic mechanism reduction based on an integer programming approach by Androulakis, Ioannis P.

“…An approach toward kinetic mechanism reduction, both in terms of reactions and species, is discussed. The driving force of the approach is to derive reduced…”
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A novel non-overlapping bi-clustering algorithm for network generation using living cell array data by Yang, E., Foteinou, P.T., King, K.R., Yarmush, M.L., Androulakis, I.P.

“…Motivation: The living cell array quantifies the contribution of activated transcription factors upon the expression levels of their target genes. The direct…”
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Translational Potential of Systems-Based Models of Inflammation by Foteinou, P.T., Calvano, S.E., Lowry, S.F., Androulakis, I.P.

“…A critical goal of translational research is to convert basic science to clinically relevant actions related to disease prevention, diagnosis, and eventually…”
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Informative gene selection and design of regulatory networks using integer optimization by Yang, E., Maguire, T., Yarmush, M.L., Androulakis, I.P.

“…A central problem in bioinformatics and systems biology is the selection of appropriate models in a rational and systematic way. This fundamentally…”
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Application of Computational Kinetic Mechanism Generation to Model the Autocatalytic Pyrolysis of Methane by Grenda, Jeffrey M, Androulakis, Ioannis P, Dean, Anthony M, Green, William H

“…An automated computational mechanism-generation technique is applied to construct elementary-step chemical kinetic reaction models for the pyrolysis of methane…”
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Identification of regulatory mechanisms of the hepatic response to thermal injury by Yang, E., Maguire, T.J., Yarmush, M.L., Berthiaume, F., Androulakis, I.P.

“…The purpose of this paper is to evaluate the hypothesis that a systems biology approach can be developed such that a set of transcription factors, relevant to…”
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The Contribution of Gas-Phase Reactions in the Pt-Catalyzed Conversion of Ethane–Oxygen Mixtures by Huff, Marylin C., Androulakis, Ioannis P., Sinfelt, John H., Reyes, Sebastián C.

“…This paper presents an analysis of the oxidative dehydrogenation of ethane on platinum-containing monoliths. The purpose of the work is to make a quantitative…”
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Design of flexible reduced kinetic mechanisms by Sirdeshpande, Avinash R., Ierapetritou, Marianthi G., Androulakis, Ioannis P.

“…Reduced mechanisms are often used in place of detailed chemistry because the computational burden of including all the species continuity equations in the…”
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