Search Results - "Andronova, Valeria L."
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Synthesis of Substituted 1,2,4-Triazole-3-Thione Nucleosides Using E. coli Purine Nucleoside Phosphorylase
Published in Biomolecules (Basel, Switzerland) (01-07-2024)“…1,2,4-Triazole derivatives have a wide range of biological activities. The most well-known drug that contains 1,2,4-triazole as part of its structure is the…”
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Phosphoramidate derivatives of acyclovir: Synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro
Published in Bioorganic & medicinal chemistry (01-10-2012)“…The antiviral activity against HIV and HSV and the chemical stability of ACV phosphoramidate derivatives were studied. The phosphoramidates of ACV demonstrated…”
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N‐[ω‐(Purin‐6‐yl)aminoalkanoyl] Derivatives of Chiral Heterocyclic Amines as Promising Anti‐Herpesvirus Agents
Published in European journal of organic chemistry (15-08-2019)“…Novel conjugates of 2‐aminopurine and purine containing fragments of chiral heterocyclic amines attached at position 6 of purine core via a linker, fragment of…”
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New modified 2-aminobenzimidazole nucleosides: Synthesis and evaluation of their activity against herpes simplex virus type 1
Published in Bioorganic & medicinal chemistry letters (01-06-2017)“…[Display omitted] Using the enzymatic transglycosylation reaction β-d-ribo- and 2′-deoxyribofuranosides of 2-amino-5,6-difluorobenzimidazole nucleosides have…”
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Enzymatic synthesis of novel purine nucleosides bearing a chiral benzoxazine fragment
Published in Chemical biology & drug design (01-04-2019)“…A series of ribo‐ and deoxyribonucleosides bearing 2‐aminopurine as a nucleobase with 7,8‐difluoro‐ 3,4‐dihydro‐3‐methyl‐2H‐[1,4]benzoxazine (conjugated…”
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Antiherpetic Properties of Acyclovir 5'-Hydrogenphosphonate and the Mutation Analysis of Herpes Virus Resistant Strains
Published in Chemical biology & drug design (01-10-2009)“…In this study, we continued to study antiherpetic properties of acyclovir 5'-hydrogenphosphonate (Hp-ACV) in cell cultures and animal models. Hp-ACV was shown…”
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Favipiravir and Its Structural Analogs: Antiviral Activity and Synthesis Methods
Published in Actanaturae (01-04-2022)“…1,4-Pyrazine-3-carboxamide-based antiviral compounds have been under intensive study for the last 20 years. One of these compounds, favipiravir…”
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Chemo-enzymatic synthesis of 5-substituted ribavirin analogs: Unexpected cooperative effect in the interaction of 5-alkyloxymethyl 1,2,4-triazol-3-carboxamides with E. coli purine nucleoside phosphorylase active site
Published in Sustainable chemistry and pharmacy (01-12-2022)“…A series of 5-alkyl/aryl-oxymethyl-ribavirin analogs was synthesized. Surprisingly, ability of E. coli purine nucleoside phosphorylase (PNP) to synthesize…”
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