Search Results - "Andronesi, Ovidiu C."

Isocitrate dehydrogenase‐mutant glioma: Evolving clinical and therapeutic implications by Miller, Julie J., Shih, Helen A., Andronesi, Ovidiu C., Cahill, Daniel P.

“…The metabolic genes isocitrate dehydrogenase 1 (IDH1) and IDH2 are commonly mutated in low‐grade glioma and in a subset of glioblastoma. These mutations…”
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Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations by Maudsley, Andrew A., Andronesi, Ovidiu C., Barker, Peter B., Bizzi, Alberto, Bogner, Wolfgang, Henning, Anke, Nelson, Sarah J., Posse, Stefan, Shungu, Dikoma C., Soher, Brian J.

“…Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for monitoring metabolic alterations associated with disease or injury; however, to…”
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Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate by Andronesi, Ovidiu C., Arrillaga-Romany, Isabel C., Ly, K. Ina, Bogner, Wolfgang, Ratai, Eva M., Reitz, Kara, Iafrate, A. John, Dietrich, Jorg, Gerstner, Elizabeth R., Chi, Andrew S., Rosen, Bruce R., Wen, Patrick Y., Cahill, Daniel P., Batchelor, Tracy T.

“…Inhibitors of the mutant isocitrate dehydrogenase 1 ( IDH1 ) entered recently in clinical trials for glioma treatment. Mutant IDH1 produces high levels of…”
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Consensus recommendations for MRI and PET imaging of primary central nervous system lymphoma: guideline statement from the International Primary CNS Lymphoma Collaborative Group (IPCG) by Barajas, Ramon F, Politi, Letterio S, Anzalone, Nicoletta, Schöder, Heiko, Fox, Christopher P, Boxerman, Jerrold L, Kaufmann, Timothy J, Quarles, C Chad, Ellingson, Benjamin M, Auer, Dorothee, Andronesi, Ovidiu C, Ferreri, Andres J M, Mrugala, Maciej M, Grommes, Christian, Neuwelt, Edward A, Ambady, Prakash, Rubenstein, James L, Illerhaus, Gerald, Nagane, Motoo, Batchelor, Tracy T, Hu, Leland S

“…Abstract Advanced molecular and pathophysiologic characterization of primary central nervous system lymphoma (PCNSL) has revealed insights into promising…”
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Advanced magnetic resonance imaging of the physical processes in human glioblastoma by Kalpathy-Cramer, Jayashree, Gerstner, Elizabeth R, Emblem, Kyrre E, Andronesi, Ovidiu, Rosen, Bruce

“…The most common malignant primary brain tumor, glioblastoma multiforme (GBM) is a devastating disease with a grim prognosis. Patient survival is typically less…”
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Treatment Response Assessment in IDH-Mutant Glioma Patients by Noninvasive 3D Functional Spectroscopic Mapping of 2-Hydroxyglutarate by Andronesi, Ovidiu C, Loebel, Franziska, Bogner, Wolfgang, Marjańska, Małgorzata, Vander Heiden, Matthew G, Iafrate, A John, Dietrich, Jorg, Batchelor, Tracy T, Gerstner, Elizabeth R, Kaelin, William G, Chi, Andrew S, Rosen, Bruce R, Cahill, Daniel P

“…Measurements of objective response rates are critical to evaluate new glioma therapies. The hallmark metabolic alteration in gliomas with mutant isocitrate…”
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Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate by Andronesi, Ovidiu C, Rapalino, Otto, Gerstner, Elizabeth, Chi, Andrew, Batchelor, Tracy T, Cahill, Dan P, Sorensen, A Gregory, Rosen, Bruce R

“…The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the…”
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Secondary Structure, Dynamics, and Topology of a Seven-Helix Receptor in Native Membranes, Studied by Solid-State NMR Spectroscopy by Etzkorn, Manuel, Martell, Swetlana, Andronesi, Ovidiu C., Seidel, Karsten, Engelhard, Martin, Baldus, Marc

“…In the loop: High‐resolution solid‐state NMR spectroscopy is used to study the secondary structure, dynamics, and membrane topology of an entire seven‐helix…”
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Molecular-Level Secondary Structure, Polymorphism, and Dynamics of Full-Length α-Synuclein Fibrils Studied by Solid-State NMR by Heise, Henrike, Hoyer, Wolfgang, Stefan Becker, Ovidiu C. Andronesi, Riedel, Dietmar, Baldus, Marc, Bax, Adriaan

“…The 140-residue protein$\alpha-synuclein$(AS) is able to form amyloid fibrils and as such is the main component of protein inclusions involved in Parkinson's…”
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Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of Rebound Revascularization as Mode of Escape by DI TOMASO, Emmanuelle, SNUDERL, Matija, HEDLEY-WHYTE, E. Tessa, SORENSEN, A. Gregory, BATCHELOR, Tracy T, JAIN, Rakesh K, KAMOUN, Walid S, DUDA, Dan G, AULUCK, Pavan K, FAZLOLLAHI, Ladan, ANDRONESI, Ovidiu C, FROSCH, Matthew P, WEN, Patrick Y, PLOTKIN, Scott R

“…Recurrent glioblastomas (rGBM) invariably relapse after initial response to anti-VEGF therapy. There are 2 prevailing hypotheses on how these tumors escape…”
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Characterization of Alzheimer’s-like Paired Helical Filaments from the Core Domain of Tau Protein Using Solid-State NMR Spectroscopy by Andronesi, Ovidiu C, Bergen, Martin von, Biernat, Jacek, Seidel, Karsten, Griesinger, Christian, Mandelkow, Eckhard, Baldus, Marc

“…The polymerization of the microtubule-associated protein tau into paired helical filaments (PHFs) represents one of the hallmarks of Alzheimer’s disease. We…”
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ACRIN 6684: Multicenter, phase II assessment of tumor hypoxia in newly diagnosed glioblastoma using magnetic resonance spectroscopy by Ratai, Eva-Maria, Zhang, Zheng, Fink, James, Muzi, Mark, Hanna, Lucy, Greco, Erin, Richards, Todd, Kim, Daniel, Andronesi, Ovidiu C, Mintz, Akiva, Kostakoglu, Lale, Prah, Melissa, Ellingson, Benjamin, Schmainda, Kathleen, Sorensen, Gregory, Barboriak, Daniel, Mankoff, David, Gerstner, Elizabeth R

“…A multi-center imaging trial by the American College of Radiology Imaging Network (ACRIN) "A Multicenter, phase II assessment of tumor hypoxia in glioblastoma…”
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Determination of Membrane Protein Structure and Dynamics by Magic-Angle-Spinning Solid-State NMR Spectroscopy by Andronesi, Ovidiu C, Becker, Stefan, Seidel, Karsten, Heise, Henrike, Young, Howard S, Baldus, Marc

“…It is shown that molecular structure and dynamics of a uniformly labeled membrane protein can be studied under magic-angle-spinning conditions. For this…”
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From genomics to the clinic: biological and translational insights of mutant IDH1/2 in glioma by Dunn, Gavin P, Andronesi, Ovidiu C, Cahill, Daniel P

“…The characterization of the genomic alterations across all human cancers is changing the way that malignant disease is defined and treated. This paradigm is…”
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Spectral editing in 1H magnetic resonance spectroscopy: Experts' consensus recommendations by Choi, In‐Young, Andronesi, Ovidiu C., Barker, Peter, Bogner, Wolfgang, Edden, Richard A. E., Kaiser, Lana G., Lee, Phil, Marjańska, Małgorzata, Terpstra, Melissa, Graaf, Robin A.

“…Spectral editing in in vivo 1H‐MRS provides an effective means to measure low‐concentration metabolite signals that cannot be reliably measured by conventional…”
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Imaging Neurochemistry and Brain Structure Tracks Clinical Decline and Mechanisms of ALS in Patients by Andronesi, Ovidiu C, Nicholson, Katharine, Jafari-Khouzani, Kourosh, Bogner, Wolfgang, Wang, Jing, Chan, James, Macklin, Eric A, Levine-Weinberg, Mark, Breen, Christopher, Schwarzschild, Michael A, Cudkowicz, Merit, Rosen, Bruce R, Paganoni, Sabrina, Ratai, Eva-Maria

“…Oxidative stress and protein aggregation are key mechanisms in amyotrophic lateral sclerosis (ALS) disease. Reduced glutathione (GSH) is the most important…”
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Serial Magnetic Resonance Spectroscopy Reveals a Direct Metabolic Effect of Cediranib in Glioblastoma by KIM, Heisoog, CATANA, Ciprian, RATAI, Eva-Maria, ANDRONESI, Ovidiu C, JENNINGS, Dominique L, BATCHELOR, Tracy T, JAIN, Rakesh K, SORENSEN, A. Gregory

“…Proton magnetic resonance spectroscopy is increasingly used in clinical studies of brain tumor to provide information about tissue metabolic profiles. In this…”
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Low-power adiabatic sequences for in vivo localized two-dimensional chemical shift correlated MR spectroscopy by Andronesi, Ovidiu C., Ramadan, Saadallah, Mountford, Carolyn E., Sorensen, A.Gregory

“…Novel low‐power adiabatic sequences are demonstrated for in vivo localized two‐dimensional correlated MR spectroscopy, such as correlated spectroscopy and…”
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Precision oncology in the era of radiogenomics: the case of D-2HG as an imaging biomarker for mutant IDH gliomas by Andronesi, Ovidiu C

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Whole‐Slab 3D MR Spectroscopic Imaging of the Human Brain With Spiral‐Out‐In Sampling at 7T by Esmaeili, Morteza, Strasser, Bernhard, Bogner, Wolfgang, Moser, Philipp, Wang, Zhe, Andronesi, Ovidiu C.

“…Background Metabolic imaging using proton magnetic resonance spectroscopic imaging (MRSI) has increased the sensitivity and spectral resolution at field…”
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