Genistein modulates the estrogen receptor and suppresses angiogenesis and inflammation in the murine model of peritoneal endometriosis

The purpose of this study was to investigate the effect of genistein administration on the modulation of the estrogen receptor, inhibition of inflammation and angiogenesis in the murine model of peritoneal endometriosis. A total of thirty-six mice (Mus musculus) were divided into six groups (n = 6),...

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Published in:	Journal of Traditional and Complementary Medicine Vol. 8; no. 2; pp. 278 - 281
Main Authors:	Sutrisno, Sutrisno, Aprina, Hardianti, Simanungkalit, Happy Marthalena, Andriyani, Asti, Barlianto, Wisnu, Sujuti, Hidayat, Santoso, Sanarto, Dwijayasa, Pande Made, Wahyuni, Endang Sri, Mustofa, Edy
Format:	Journal Article
Language:	English
Published:	Netherlands 國立臺灣大學食品與生物分子研究中心 01-04-2018 Elsevier Taiwan LLC Elsevier
Subjects:	Angiogenesis Estrogen receptor Growth factor Inflammation Original Peritoneum Estrogen receptor Angiogenesis Inflammation Growth factor Peritoneum
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Summary:	The purpose of this study was to investigate the effect of genistein administration on the modulation of the estrogen receptor, inhibition of inflammation and angiogenesis in the murine model of peritoneal endometriosis. A total of thirty-six mice (Mus musculus) were divided into six groups (n = 6), including the control group, endometriosis group, endometriosis group treated with various doses of genistein (0.78; 1.04; 1.3 mg/day), and endometriosis group treated with leuprolide acetate (0.00975 mg/day every 5 days for 15 days). Analysis of estrogen receptor-α, estrogen receptor-β, TNF-α, IL-6, VEGF, and HIF-1α were performed immunohistochemically. Expression of estrogen receptor-α, estrogen receptor-β, TNF-α, IL-6, VEGF and HIF-1α increased significantly compared with the control group (p ＜ 0.05). All doses of genistein decreased the expression of estrogen receptor-α, increased estrogen receptor-β, lowered VEGF and HIF-1α significantly compared with endometriosis group (p ＞ 0.05). Genistein also decreased the expression of TNF-α and IL-6 (1.04 and 1.3 mg/day) compared with the endometriosis group, reaching level comparable to that of the control group (p ＞ 0.05). It was concluded that genistein is able to modulate estrogen receptor-α and estrogen receptor-b and inhibit the development of inflammation and angiogenesis in the murine model of peritoneal endometriosis. Thus, genistein can be a candidate in the treatment of endometriosis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2225-4110 2225-4110
DOI:	10.1016/j.jtcme.2017.03.002