Search Results - "Andrieux, Annie"
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Tubulin post‐translational modifications control neuronal development and functions
Published in Developmental neurobiology (Hoboken, N.J.) (01-04-2021)“…Microtubules (MTs) are an essential component of the neuronal cytoskeleton; they are involved in various aspects of neuron development, maintenance, and…”
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Altering the course of schizophrenia: progress and perspectives
Published in Nature reviews. Drug discovery (01-07-2016)“…Key Points Schizophrenia is a debilitating and chronic disorder that is accompanied by psychosis and a broad spectrum of behavioural, cognitive and social…”
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Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly
Published in Nature genetics (01-06-2013)“…Jamel Chelly, Nicholas Cowan and colleagues report mutations in TUBG1 , DYNC1H1 , KIF2A and KIF5C in individuals with malformations of cortical development and…”
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4
Tau co-organizes dynamic microtubule and actin networks
Published in Scientific reports (05-05-2015)“…The crosstalk between microtubules and actin is essential for cellular functions. However, mechanisms underlying the microtubule-actin organization by…”
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AutoNeuriteJ: An ImageJ plugin for measurement and classification of neuritic extensions
Published in PloS one (16-07-2020)“…Morphometry characterization is an important procedure in describing neuronal cultures and identifying phenotypic differences. This task usually requires…”
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Motor-dependent microtubule disassembly driven by tubulin tyrosination
Published in The Journal of cell biology (29-06-2009)“…In cells, stable microtubules (MTs) are covalently modified by a carboxypeptidase, which removes the C-terminal Tyr residue of α-tubulin. The significance of…”
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Tau can switch microtubule network organizations: from random networks to dynamic and stable bundles
Published in Molecular biology of the cell (15-01-2018)“…In neurons, microtubule networks alternate between single filaments and bundled arrays under the influence of effectors controlling their dynamics and…”
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Structural basis of tubulin detyrosination by the vasohibin–SVBP enzyme complex
Published in Nature structural & molecular biology (01-07-2019)“…Vasohibins are tubulin tyrosine carboxypeptidases that are important in neuron physiology. We examined the crystal structures of human vasohibin 1 and 2 in…”
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Dissociated features of social cognition altered in mouse models of schizophrenia: Focus on social dominance and acoustic communication
Published in Neuropharmacology (15-11-2019)“…Social and communication impairments are common features of psychiatric disorders. Animal models of schizophrenia display various social deficits due to…”
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10
Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility
Published in Journal of cell science (01-02-2019)“…Sperm cells are highly specialized mammalian cells, and their biogenesis requires unique intracellular structures. Perturbation of spermatogenesis often leads…”
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Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis
Published in Cell (22-02-2018)“…Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent…”
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Functional Dysregulations in CA1 Hippocampal Networks of a 3-Hit Mouse Model of Schizophrenia
Published in International journal of molecular sciences (01-03-2021)“…For a better translation from treatment designs of schizophrenia to clinical efficiency, there is a crucial need to refine preclinical animal models. In order…”
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The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids
Published in Molecular biology of the cell (01-10-2014)“…The posttranslational modification of carboxy-terminal tails of tubulin plays an important role in the regulation of the microtubule cytoskeleton. Enzymes…”
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14
AutoNeuriteJ: An ImageJ plugin for measurement and classification of neuritic extensions
Published in PloS one (16-06-2020)“…Morphometry characterization is an important procedure in describing neuronal cultures and identifying phenotypic differences. This task usually requires…”
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15
Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends
Published in The Journal of cell biology (11-09-2006)“…Tubulin-tyrosine ligase (TTL), the enzyme that catalyzes the addition of a C-terminal tyrosine residue to α-tubulin in the tubulin tyrosination cycle, is…”
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The GSK3–MAP1B pathway controls neurite branching and microtubule dynamics
Published in Molecular and cellular neuroscience (01-04-2016)“…The microtubule-associated protein MAP1B plays a key role in axon regeneration. We investigated the role of GSK3-mediated MAP1B phosphorylation in local…”
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A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines
Published in Nature communications (17-09-2018)“…Emerging evidence indicates that microtubule-associated proteins (MAPs) are implicated in synaptic function; in particular, mice deficient for MAP6 exhibit…”
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Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories
Published in Frontiers in molecular neuroscience (05-05-2021)“…The development and function of the central nervous system rely on the microtubule (MT) and actin cytoskeletons and their respective effectors. Although the…”
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Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin
Published in eLife (26-05-2020)“…Studies have suggested that amyloid precursor protein (APP) regulates synaptic homeostasis, but the evidence has not been consistent. In particular, signaling…”
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Neuronal transport defects of the MAP6 KO mouse – a model of schizophrenia – and alleviation by Epothilone D treatment, as observed using MEMRI
Published in NeuroImage (Orlando, Fla.) (01-08-2014)“…The MAP6 (microtubule-associated protein 6) KO mouse is a microtubule-deficient model of schizophrenia that exhibits severe behavioral disorders that are…”
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