Anti-inflammatory effects of liposomes

Studies of antiexudative, antialterative, and antibacterial effects of lecithin-cholesterol liposomes suggest their possible use as antiinflammatory agents. It is shown that incubation of liposomes with opportunistic microorganisms is attended with a pronounced antibacterial effect, while subcutaneo...

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Bibliographic Details
Published in:	Vestnik Akademii meditsinskikh nauk SSSR no. 6; p. 44
Main Authors:	Kreĭnes, V M, Mel'nikova, V M, Margolin, Ia M, Mel'iantseva, L P, Gladshteĭn, A I, Andriasian, B A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1990
Subjects:	Animals Cholesterol - administration & dosage Cholesterol - pharmacology Cholesterol - therapeutic use Edema - chemically induced Edema - drug therapy Edema - microbiology Escherichia coli - drug effects Formaldehyde Hindlimb In Vitro Techniques Inflammation - chemically induced Inflammation - drug therapy Injections, Subcutaneous Liposomes - administration & dosage Liposomes - pharmacology Liposomes - therapeutic use Phosphatidylcholines - administration & dosage Phosphatidylcholines - pharmacology Phosphatidylcholines - therapeutic use Rats Rats, Inbred Strains Staphylococcus aureus - drug effects
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Summary:	Studies of antiexudative, antialterative, and antibacterial effects of lecithin-cholesterol liposomes suggest their possible use as antiinflammatory agents. It is shown that incubation of liposomes with opportunistic microorganisms is attended with a pronounced antibacterial effect, while subcutaneous injection of liposomes significantly reduces the soft tissue edema caused by administration of formalin, and prevents pronounced alteration in response to acetic acid solution. A conclusion is derived on the possibility to use the membranotropic properties of liposomal membranes to alleviate manifestations of inflammation.
ISSN:	0002-3027