Comparison of Antioxidative Effect of Metformin and Combination of Metformin-Sulfonylurea in Type 2 Diabetes Mellitus Patients

Comparison of Antioxidative Effect of Metformin and Combination of Metformin-Sulfonylurea in Type 2 Diabetes Mellitus Patients

Background: Even though oxidative stress is intensively studied for its role in diabetic nephropathy, the effectiveness of first-line medication on diabetes in preventing oxidative stress and diabetic nephropathy is still unknown. This study aimed to analyze 8-iso-Prostaglandin F2α, UACR, and their...

Full description

Saved in:
Bibliographic Details
Published in:Journal of young pharmacists Vol. 9; no. 1s; pp. s39 - s42
Main Authors: Sauriasari, Rani, Andriany, Raja, Sekar, Andisyah Putri, A, Azizahwati
Format: Journal Article
Language:English
Published: Bangalore InPharm 01-01-2017
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Even though oxidative stress is intensively studied for its role in diabetic nephropathy, the effectiveness of first-line medication on diabetes in preventing oxidative stress and diabetic nephropathy is still unknown. This study aimed to analyze 8-iso-Prostaglandin F2α, UACR, and their correlation on 114 type 2 diabetes mellitus patients who consumed metformin and the combination of metformin-sulfonylurea. Material and Method: Urinary 8-iso-Prostaglandin F2α was measured by ELISA and urinary albumin was measured by Bromocresol Green Albumin assay. Results: The results showed that HbA1c (p=0.038) and 8-iso-Prostaglandin F2α level higher in the combination group than in metformin group, but not for UACR (p=0.838). However, subgroup analysis on albuminuric patients (UACR>30 mg/g, n=55) showed no different in HbA1c and 8-iso- Prostaglandin F2α level between the medication groups. Linear regression analysis showed HbA1c (β=0.402, p=0.002) and the combination of metformin-sulfonylurea (β=0.364, p=0.004) were the most predictive factors for increased UACR after controlled by age, gender, IMT, systolic blood pressure, 8-iso-Prostaglandin F2α, smoking habit and exercise habit. Conclusion: In conclusion, metformin was more effective in decreasing 8-iso-Prostaglandin F2α level, an oxidative stress marker. The increase of HbA1c and the use of a combination of metformin-sulfonylurea contributed in increased UACR in this study.
ISSN:0975-1483
0975-1505
DOI:10.5530/jyp.2017.1s.10