Search Results - "Andrews, Zane B."

The extra-hypothalamic actions of ghrelin on neuronal function by Andrews, Zane B

“…Ghrelin is a peptide hormone produced and secreted in the stomach. Numerous studies over the past decade demonstrate its importance in food intake, body-weight…”
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Central mechanisms involved in the orexigenic actions of ghrelin by Andrews, Zane B.

“…Ghrelin is a stomach hormone, secreted into the bloodstream, that initiates food intake by activating NPY/AgRP neurons in the hypothalamic acruate nucleus…”
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Obesity Impairs the Action of the Neuroendocrine Ghrelin System by Zigman, Jeffrey M, Bouret, Sebastien G, Andrews, Zane B

“…Ghrelin is a metabolic hormone that promotes energy conservation by regulating appetite and energy expenditure. Although some studies suggest that antagonizing…”
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Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat by Dodd, Garron T., Decherf, Stephanie, Loh, Kim, Simonds, Stephanie E., Wiede, Florian, Balland, Eglantine, Merry, Troy L., Münzberg, Heike, Zhang, Zhong-Yin, Kahn, Barbara B., Neel, Benjamin G., Bence, Kendra K., Andrews, Zane B., Cowley, Michael A., Tiganis, Tony

“…The primary task of white adipose tissue (WAT) is the storage of lipids. However, “beige” adipocytes also exist in WAT. Beige adipocytes burn fat and dissipate…”
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Ghrelin’s Role in the Hypothalamic-Pituitary-Adrenal Axis Stress Response: Implications for Mood Disorders by Spencer, Sarah J, Emmerzaal, Tim L, Kozicz, Tamas, Andrews, Zane B

“…Abstract Ghrelin is a stomach hormone normally associated with feeding behavior and energy homeostasis. Recent studies highlight that ghrelin targets the brain…”
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Ghrelin-Mediated Hippocampal Neurogenesis: Implications for Health and Disease by Buntwal, Luke, Sassi, Martina, Morgan, Alwena H., Andrews, Zane B., Davies, Jeffrey S.

“…There is a close relationship between cognition and nutritional status, however, the mechanisms underlying this relationship require elucidation. The stomach…”
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Ghrelin Regulates the Hypothalamic-Pituitary-Adrenal Axis and Restricts Anxiety After Acute Stress by Spencer, Sarah J, Xu, Lu, Clarke, Melanie A, Lemus, Moyra, Reichenbach, Alex, Geenen, Bram, Kozicz, Tamás, Andrews, Zane B

“…Background Ghrelin plays important roles in glucose metabolism, appetite, and body weight regulation, and recent evidence suggests ghrelin prevents excessive…”
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Neonatal ghrelin programs development of hypothalamic feeding circuits by Steculorum, Sophie M, Collden, Gustav, Coupe, Berengere, Croizier, Sophie, Lockie, Sarah, Andrews, Zane B, Jarosch, Florian, Klussmann, Sven, Bouret, Sebastien G

“…A complex neural network regulates body weight and energy balance, and dysfunction in the communication between the gut and this neural network is associated…”
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Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse by Mani, Bharath K., Walker, Angela K., Lopez Soto, Eduardo J., Raingo, Jesica, Lee, Charlotte E., Perelló, Mario, Andrews, Zane B., Zigman, Jeffrey M.

“…ABSTRACT Growth hormone secretagogue receptor (GHSR) 1a is the only molecularly identified receptor for ghrelin, mediating ghrelin‐related effects on eating,…”
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Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease by Bayliss, Jacqueline A, Lemus, Moyra B, Stark, Romana, Santos, Vanessa V, Thompson, Aiysha, Rees, Daniel J, Galic, Sandra, Elsworth, John D, Kemp, Bruce E, Davies, Jeffrey S, Andrews, Zane B

“…Calorie restriction (CR) is neuroprotective in Parkinson's disease (PD) although the mechanisms are unknown. In this study we hypothesized that elevated…”
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Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity by Dodd, Garron T., Xirouchaki, Chrysovalantou E., Eramo, Matthew, Mitchell, Christina A., Andrews, Zane B., Henry, Belinda A., Cowley, Michael A., Tiganis, Tony

“…The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear. The tyrosine phosphatases protein…”
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Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health by Abulizi, Abudukadier, Cardone, Rebecca L., Stark, Romana, Lewandowski, Sophie L., Zhao, Xiaojian, Hillion, Joelle, Ma, Lingjun, Sehgal, Raghav, Alves, Tiago C., Thomas, Craig, Kung, Charles, Wang, Bei, Siebel, Stephan, Andrews, Zane B., Mason, Graeme F., Rinehart, Jesse, Merrins, Matthew J., Kibbey, Richard G.

“…The mitochondrial GTP (mtGTP)-dependent phosphoenolpyruvate (PEP) cycle couples mitochondrial PEPCK (PCK2) to pyruvate kinase (PK) in the liver and pancreatic…”
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Diet-Induced Obesity Causes Ghrelin Resistance in Arcuate NPY/AgRP Neurons by Briggs, Dana I, Enriori, Pablo J, Lemus, Moyra B, Cowley, Michael A, Andrews, Zane B

“…Circulating ghrelin is decreased in obesity, and peripheral ghrelin does not induce food intake in obese mice. We investigated whether ghrelin resistance was a…”
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Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons by Bayliss, Jacqueline A, Lemus, Moyra B, Santos, Vanessa V, Deo, Minh, Davies, Jeffrey S, Kemp, Bruce E, Elsworth, John D, Andrews, Zane B

“…Metformin is a widely prescribed drug used to treat type-2 diabetes, although recent studies show it has wide ranging effects to treat other diseases. Animal…”
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UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals by Horvath, Tamas L, Diano, Sabrina, Andrews, Zane B, Liu, Zhong-Wu, Walllingford, Nicholas, Erion, Derek M, Borok, Erzsebet, Friedman, Jeffery M, Tschöp, Matthias H, Shanabrough, Marya, Cline, Gary, Shulman, Gerald I, Coppola, Anna, Gao, Xiao-Bing

“…The gut-derived hormone ghrelin exerts its effect on the brain by regulating neuronal activity. Ghrelin-induced feeding behaviour is controlled by arcuate…”
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Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance by Loh, Kim, Fukushima, Atsushi, Zhang, Xinmei, Galic, Sandra, Briggs, Dana, Enriori, Pablo J., Simonds, Stephanie, Wiede, Florian, Reichenbach, Alexander, Hauser, Christine, Sims, Natalie A., Bence, Kendra K., Zhang, Sheng, Zhang, Zhong-Yin, Kahn, Barbara B., Neel, Benjamin G., Andrews, Zane B., Cowley, Michael A., Tiganis, Tony

“…In obesity, anorectic responses to leptin are diminished, giving rise to the concept of “leptin resistance.” Increased expression of protein tyrosine…”
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AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis by Galic, Sandra, Loh, Kim, Murray-Segal, Lisa, Steinberg, Gregory R, Andrews, Zane B, Kemp, Bruce E

“…AMP-activated protein kinase (AMPK) is a known regulator of whole-body energy homeostasis, but the downstream AMPK substrates mediating these effects are not…”
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Metabolic status regulates ghrelin function on energy homeostasis by Briggs, Dana I, Andrews, Zane B

“…Ghrelin plays an important role in energy metabolism by regulating food intake, body weight and glucose homeostasis. In this review, we highlight recent…”
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The Temporal Pattern of cfos Activation in Hypothalamic, Cortical, and Brainstem Nuclei in Response to Fasting and Refeeding in Male Mice by Wu, Qunli, Lemus, Moyra B, Stark, Romana, Bayliss, Jacqueline A, Reichenbach, Alex, Lockie, Sarah H, Andrews, Zane B

“…In this study we examined fasted and refed cfos activation in cortical, brainstem, and hypothalamic brain regions associated with appetite regulation. We…”
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Exercise-Induced Synaptogenesis in the Hippocampus Is Dependent on UCP2-Regulated Mitochondrial Adaptation by Dietrich, Marcelo O, Andrews, Zane B, Horvath, Tamas L

“…Mitochondria are essential organelles in neurons providing appropriate energetic needs to maintain resting and action potentials as well as to modulate…”
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