Search Results - "Andrews, Nancy C"

Iron and Copper in Mitochondrial Diseases by Xu, Wenjing, Barrientos, Tomasa, Andrews, Nancy C.

“…Transition metals are frequently used as cofactors for enzymes and oxygen-carrying proteins that take advantage of their propensity to gain and lose single…”
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Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart by Xu, Wenjing, Barrientos, Tomasa, Mao, Lan, Rockman, Howard A., Sauve, Anthony A., Andrews, Nancy C.

“…Both iron overload and iron deficiency have been associated with cardiomyopathy and heart failure, but cardiac iron utilization is incompletely understood. We…”
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Interleukin-6 induces hepcidin expression through STAT3 by Wrighting, Diedra M., Andrews, Nancy C.

“…Iron homeostasis is maintained through meticulous regulation of circulating hepcidin levels. Hepcidin levels that are inappropriately low or high result in…”
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Iron homeostasis by Andrews, Nancy C, Schmidt, Paul J

“…Iron is needed by all mammalian cells but is toxic in excess. Specialized transport mechanisms conduct iron across cellular membranes. These are regulated to…”
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Hereditary Hemochromatosis Protein, HFE, Interaction with Transferrin Receptor 2 Suggests a Molecular Mechanism for Mammalian Iron Sensing by Goswami, Tapasree, Andrews, Nancy C.

“…HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human hereditary hemochromatosis. Here…”
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Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis by Chen, Alan C., Donovan, Adriana, Ned-Sykes, Renee, Andrews, Nancy C.

“…Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin. It is expressed in the…”
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Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice by Matak, Pavle, Matak, Andrija, Moustafa, Sarah, Aryal, Dipendra K., Benner, Eric J., Wetsel, William, Andrews, Nancy C.

“…Disrupted brain iron homeostasis is a common feature of neurodegenerative disease. To begin to understand how neuronal iron handling might be involved, we…”
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A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency by Jabara, Haifa H, Boyden, Steven E, Chou, Janet, Ramesh, Narayanaswamy, Massaad, Michel J, Benson, Halli, Bainter, Wayne, Fraulino, David, Rahimov, Fedik, Sieff, Colin, Liu, Zhi-Jian, Alshemmari, Salem H, Al-Ramadi, Basel K, Al-Dhekri, Hasan, Arnaout, Rand, Abu-Shukair, Mohammad, Vatsayan, Anant, Silver, Eli, Ahuja, Sanjay, Davies, E Graham, Sola-Visner, Martha, Ohsumi, Toshiro K, Andrews, Nancy C, Notarangelo, Luigi D, Fleming, Mark D, Al-Herz, Waleed, Kunkel, Louis M, Geha, Raif S

“…Raif Geha, Louis Kunkel, Waleed Al-Herz and colleagues report a mutation in TFRC (encoding transferrin receptor 1, TfR1) that causes combined immunodeficiency…”
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channel kinase, TRPM7, is required for early embryonic development by Jin, Jie, Wu, Long-Jun, Jun, Janice, Cheng, Xiping, Xu, Haoxing, Andrews, Nancy C, Clapham, David E

“…Global disruption of transient receptor potential-melastatin-like 7 (Trpm7) in mice results in embryonic lethality before embryonic day 7. Using…”
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Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA) by Andrews, Nancy C, Fleming, Mark D, Finberg, Karin E, Heeney, Matthew M, Campagna, Dean R, Ayd nok, Ye im, Pearson, Howard A, Hartman, Kip R, Mayo, Mary M, Samuel, Stewart M, Strouse, John J, Markianos, Kyriacos

“…Iron deficiency is usually attributed to chronic blood loss or inadequate dietary intake. Here, we show that iron deficiency anemia refractory to oral iron…”
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Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance by Babitt, Jodie L, Huang, Franklin W, Xia, Yin, Sidis, Yisrael, Andrews, Nancy C, Lin, Herbert Y

“…Systemic iron balance is regulated by hepcidin, a peptide hormone secreted by the liver. By decreasing cell surface expression of the iron exporter…”
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The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression by Schmidt, Paul J., Toran, Paul T., Giannetti, Anthony M., Bjorkman, Pamela J., Andrews, Nancy C.

“…Hemochromatosis is caused by mutations in HFE, a protein that competes with transferrin (TF) for binding to transferrin receptor 1 (TFR1). We developed mutant…”
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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis by Donovan, Adriana, Lima, Christine A., Pinkus, Jack L., Pinkus, Geraldine S., Zon, Leonard I., Robine, Sylvie, Andrews, Nancy C.

“…Ferroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release. Hepcidin, a regulatory peptide,…”
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Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver by Gunshin, Hiromi, Fujiwara, Yuko, Custodio, Angel O, Direnzo, Cristina, Robine, Sylvie, Andrews, Nancy C

“…Solute carrier family 11, member 2 (SLC11A2) is the only transmembrane iron transporter known to be involved in cellular iron uptake. It is widely expressed…”
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Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses by Choe, Hyeryun, Radoshitzky, Sheli R, Abraham, Jonathan, Spiropoulou, Christina F, Kuhn, Jens H, Nguyen, Dan, Li, Wenhui, Nagel, Jane, Schmidt, Paul J, Nunberg, Jack H, Andrews, Nancy C, Farzan, Michael

“…At least five arenaviruses cause viral haemorrhagic fevers in humans. Lassa virus, an Old World arenavirus, uses the cellular receptor -dystroglycan to infect…”
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Scara5 Is a Ferritin Receptor Mediating Non-Transferrin Iron Delivery by Li, Jau Yi, Paragas, Neal, Ned, Renee M., Qiu, Andong, Viltard, Melanie, Leete, Thomas, Drexler, Ian R., Chen, Xia, Sanna-Cherchi, Simone, Mohammed, Farah, Williams, David, Lin, Chyuan Sheng, Schmidt-Ott, Kai M., Andrews, Nancy C., Barasch, Jonathan

“…Developing organs require iron for a myriad of functions, but embryos deleted of the major adult transport proteins, transferrin or its receptor transferrin…”
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Iron homeostasis: insights from genetics and animal models by Andrews, Nancy C

“…Disorders that perturb iron balance are among the most prevalent human diseases, but until recently iron transport remained poorly understood. Over the past…”
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Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines by Hansen, Jakob Bondo, Tonnesen, Morten Fog, Madsen, Andreas Nygaard, Hagedorn, Peter H., Friberg, Josefine, Grunnet, Lars Groth, Heller, R. Scott, Nielsen, Anja Østergren, Størling, Joachim, Baeyens, Luc, Anker-Kitai, Leeat, Qvortrup, Klaus, Bouwens, Luc, Efrat, Shimon, Aalund, Mogens, Andrews, Nancy C., Billestrup, Nils, Karlsen, Allan E., Holst, Birgitte, Pociot, Flemming, Mandrup-Poulsen, Thomas

“…Reactive oxygen species (ROS) contribute to target-cell damage in inflammatory and iron-overload diseases. Little is known about iron transport regulation…”
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Proinflammatory state, hepcidin, and anemia in older persons by Ferrucci, Luigi, Semba, Richard D., Guralnik, Jack M., Ershler, William B., Bandinelli, Stefania, Patel, Kushang V., Sun, Kai, Woodman, Richard C., Andrews, Nancy C., Cotter, Robert J., Ganz, Tomas, Nemeth, Elizabeta, Longo, Dan L.

“…In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia. Whether the mild…”
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Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation by Roy, Cindy N., Mak, Howard H., Akpan, Imo, Losyev, Grigoriy, Zurakowski, David, Andrews, Nancy C.

“…The anemia of inflammation is an acquired disorder affecting patients with a variety of medical conditions, and it is characterized by changes in iron…”
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