Search Results - "Andrews, Ian"

Targeting Antibiotic Tolerance, Pathogen by Pathogen by Meylan, Sylvain, Andrews, Ian W., Collins, James J.

“…Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal effects of antibiotic treatment, plays a critical and…”
Get full text

A Deep Learning Approach to Antibiotic Discovery by Stokes, Jonathan M., Yang, Kevin, Swanson, Kyle, Jin, Wengong, Cubillos-Ruiz, Andres, Donghia, Nina M., MacNair, Craig R., French, Shawn, Carfrae, Lindsey A., Bloom-Ackermann, Zohar, Tran, Victoria M., Chiappino-Pepe, Anush, Badran, Ahmed H., Andrews, Ian W., Chory, Emma J., Church, George M., Brown, Eric D., Jaakkola, Tommi S., Barzilay, Regina, Collins, James J.

“…Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep…”
Get full text

Clinical Characteristics and Functional Motor Outcomes of Enterovirus 71 Neurological Disease in Children by Teoh, Hooi-Ling, Mohammad, Shekeeb S, Britton, Philip N, Kandula, Tejaswi, Lorentzos, Michelle S, Booy, Robert, Jones, Cheryl A, Rawlinson, William, Ramachandran, Vidiya, Rodriguez, Michael L, Andrews, P Ian, Dale, Russell C, Farrar, Michelle A, Sampaio, Hugo

“…Enterovirus 71 (EV71) causes a spectrum of neurological complications with significant morbidity and mortality. Further understanding of the characteristics of…”
Get more information

Modulating the evolutionary trajectory of tolerance using antibiotics with different metabolic dependencies by Zheng, Erica J., Andrews, Ian W., Grote, Alexandra T., Manson, Abigail L., Alcantar, Miguel A., Earl, Ashlee M., Collins, James J.

“…Antibiotic tolerance, or the ability of bacteria to survive antibiotic treatment in the absence of genetic resistance, has been linked to chronic and recurrent…”
Get full text

A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria by Stokes, Jonathan M., Gutierrez, Arnaud, Lopatkin, Allison J., Andrews, Ian W., French, Shawn, Matic, Ivan, Brown, Eric D., Collins, James J.

“…Antibiotic screens typically rely on growth inhibition to characterize compound bioactivity—an approach that cannot be used to assess the bactericidal activity…”
Get full text

A Deep Learning Approach to Antibiotic Discovery by Stokes, Jonathan M., Yang, Kevin, Swanson, Kyle, Jin, Wengong, Cubillos-Ruiz, Andres, Donghia, Nina M., MacNair, Craig R., French, Shawn, Carfrae, Lindsey A., Bloom-Ackermann, Zohar, Tran, Victoria M., Chiappino-Pepe, Anush, Badran, Ahmed H., Andrews, Ian W., Chory, Emma J., Church, George M., Brown, Eric D., Jaakkola, Tommi S., Barzilay, Regina, Collins, James J.

Get full text

ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism by Desai, Radha, Frazier, Ann E, Durigon, Romina, Patel, Harshil, Jones, Aleck W, Dalla Rosa, Ilaria, Lake, Nicole J, Compton, Alison G, Mountford, Hayley S, Tucker, Elena J, Mitchell, Alice L R, Jackson, Deborah, Sesay, Abdul, Di Re, Miriam, van den Heuvel, Lambert P, Burke, Derek, Francis, David, Lunke, Sebastian, McGillivray, George, Mandelstam, Simone, Mochel, Fanny, Keren, Boris, Jardel, Claude, Turner, Anne M, Ian Andrews, P, Smeitink, Jan, Spelbrink, Johannes N, Heales, Simon J, Kohda, Masakazu, Ohtake, Akira, Murayama, Kei, Okazaki, Yasushi, Lombès, Anne, Holt, Ian J, Thorburn, David R, Spinazzola, Antonella

“…Although mitochondrial disorders are clinically heterogeneous, they frequently involve the central nervous system and are among the most common neurogenetic…”
Get full text

Phosphine‐Catalyzed (4+1) Annulation: Rearrangement of Allenylic Carbamates to 3‐Pyrrolines through Phosphonium Diene Intermediates by Blank, Brian R., Andrews, Ian P., Kwon, Ohyun

“…We have developed a phosphine‐catalyzed (4+1) annulative rearrangement for the preparation of 3‐pyrrolines from allenylic carbamates via phosphonium diene…”
Get full text

Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality by Lobritz, Michael A, Andrews, Ian W, Braff, Dana, Porter, Caroline B M, Gutierrez, Arnaud, Furuta, Yoshikazu, Cortes, Louis B G, Ferrante, Thomas, Bening, Sarah C, Wong, Felix, Gruber, Charley, Bakerlee, Christopher W, Lambert, Guillaume, Walker, Graham C, Dwyer, Daniel J, Collins, James J

“…β-Lactam antibiotics disrupt the assembly of peptidoglycan (PG) within the bacterial cell wall by inhibiting the enzymatic activity of penicillin-binding…”
Get more information

Dual Responsive, Stabilized Nanoparticles for Efficient In Vivo Plasmid Delivery by Wei, Hua, Volpatti, Lisa R., Sellers, Drew L., Maris, Don O., Andrews, Ian W., Hemphill, Ashton S., Chan, Leslie W., Chu, David S. H., Horner, Philip J., Pun, Suzie H.

“…A small case of love and hate: A block‐statistical copolymer combining reversible hydrophobization and statistical hydrophilization allows the preparation of…”
Get full text

Rare copy number variants are an important cause of epileptic encephalopathies by Mefford, Heather C., Yendle, Simone C., Hsu, Cynthia, Cook, Joseph, Geraghty, Eileen, McMahon, Jacinta M., Eeg-Olofsson, Orvar, Sadleir, Lynette G., Gill, Deepak, Ben-Zeev, Bruria, Lerman-Sagie, Tally, Mackay, Mark, Freeman, Jeremy L., Andermann, Eva, Pelakanos, James T., Andrews, Ian, Wallace, Geoffrey, Eichler, Evan E., Berkovic, Samuel F., Scheffer, Ingrid E.

“…Objective: Rare copy number variants (CNVs)—deletions and duplications—have recently been established as important risk factors for both generalized and focal…”
Get full text

Phosphine-catalyzed intramolecular γ-umpolung addition of α-aminoalkylallenic esters: facile synthesis of 3-carbethoxy-2-alkyl-3-pyrrolines by Andrews, Ian P, Blank, Brian R, Kwon, Ohyun

“…An array of N-tosylated α-aminoalkylallenic esters was prepared and their cyclization under the influence of nucleophilic phosphine catalysts was explored. The…”
Get more information

Pathogenic MAST3 Variants in the STK Domain Are Associated with Epilepsy by Spinelli, Egidio, Christensen, Kyle R, Bryant, Emily, Schneider, Amy, Rakotomamonjy, Jennifer, Muir, Alison M, Giannelli, Jessica, Littlejohn, Rebecca O, Roeder, Elizabeth R, Schmidt, Berkley, Wilson, William G, Marco, Elysa J, Iwama, Kazuhiro, Kumada, Satoko, Pisano, Tiziana, Barba, Carmen, Vetro, Annalisa, Brilstra, Eva H, van Jaarsveld, Richard H, Matsumoto, Naomichi, Goldberg-Stern, Hadassa, Carney, Patrick W, Andrews, P Ian, El Achkar, Christelle M, Berkovic, Sam, Rodan, Lance H, McWalter, Kirsty, Guerrini, Renzo, Scheffer, Ingrid E, Mefford, Heather C, Mandelstam, Simone, Laux, Linda, Millichap, John J, Guemez-Gamboa, Alicia, Nairn, Angus C, Carvill, Gemma L

“…The MAST family of microtubule-associated serine-threonine kinases (STKs) have distinct expression patterns in the developing and mature human and mouse brain…”
Get full text

Histidine 114 Is Critical for ATP Hydrolysis by the Universally Conserved ATPase YchF by Rosler, Kirsten S., Mercier, Evan, Andrews, Ian C., Wieden, Hans-Joachim

“…GTPases perform a wide range of functions, ranging from protein synthesis to cell signaling. Of all known GTPases, only eight are conserved across all three…”
Get full text

Neuronal ceroid lipofuscinosis type 2: an Australian case series by Johnson, Alexandra M, Mandelstam, Simone, Andrews, Ian, Boysen, Katja, Yaplito‐Lee, Joy, Fietz, Michael, Nagarajan, Lakshmi, Rodriguez‐Casero, Victoria, Ryan, Monique M, Smith, Nicholas, Scheffer, Ingrid E, Ellaway, Carolyn

“…Aim Late infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease is a rare neurodegenerative disorder presenting in children aged 2–4 years with…”
Get full text

Synthesis of seco-B-Ring Bryostatin Analogue WN‑1 via C–C Bond-Forming Hydrogenation: Critical Contribution of the B‑Ring in Determining Bryostatin-like and Phorbol 12-Myristate 13-Acetate-like Properties by Andrews, Ian P, Ketcham, John M, Blumberg, Peter M, Kedei, Noemi, Lewin, Nancy E, Peach, Megan L, Krische, Michael J

“…The seco-B-ring bryostatin analogue, macrodiolide WN-1, was prepared in 17 steps (longest linear sequence) and 30 total steps with three bonds formed via…”
Get full text

CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection‐triggered encephalopathy syndromes by Dale, Russell C., Thomas, Terrence, Patel, Shrujna, Han, Velda X., Kothur, Kavitha, Troedson, Christopher, Gupta, Sachin, Gill, Deepak, Malone, Stephen, Waak, Michaela, Calvert, Sophie, Subramanian, Gopinath, Andrews, P. Ian, Kandula, Tejaswi, Menezes, Manoj P., Ardern‐Holmes, Simone, Mohammad, Shekeeb, Bandodkar, Sushil, Yan, Jingya

“…Objective Infection‐triggered encephalopathy syndromes (ITES) are potentially devastating neuroinflammatory conditions. Although some ITES syndromes have…”
Get full text

Relationship Between Baseline Infarct and Clinical Outcome in Pediatric Large‐Vessel Occlusion Ischemic Stroke by Bhatia, Kartik D., Parra‐Farinas, Carmen, Pulcine, Elizabeth, Dlamini, Nomazulu, Andrews, Ian, Gupta, Sachin, Webster, Richard, Troedson, Christopher, Dale, Russell C., Worthington, John, Tastula, Kylie, Ang, Timothy, Cheung, Andrew, Manning, Nathan, Miteff, Ferdinand, Miteff, Christina, Muthusami, Prakash

“…Background In adults with large‐vessel occlusion stroke, the extent of the baseline infarct measured using the Alberta Stroke Program Early Computed Tomography…”
Get full text

Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D by Gray, Paul Edgar, Shadur, Bella, Russell, Susan, Mitchell, Richard, Buckley, Michael, Gallagher, Kerri, Andrews, Ian, Thia, Kevin, Trapani, Joseph A, Kirk, Edwin Philip, Voskoboinik, Ilia

“…Bi-allelic null mutations affecting , or result in defects of lymphocyte cytotoxic degranulation and commonly cause familial hemophagocytic lymphohistiocytosis…”
Get full text

Delayed diagnosis of congenital myasthenia due to associated mitochondrial enzyme defect by Guo, Yiran, Menezes, Minal J, Menezes, Manoj P, Liang, Jinlong, Li, Dong, Riley, Lisa G, Clarke, Nigel F, Andrews, P. Ian, Tian, Lifeng, Webster, Richard, Wang, Fengxiang, Liu, Xuanzhu, Shen, Yulan, Thorburn, David R, Keating, Brendan J, Engel, Andrew, Hakonarson, Hakon, Christodoulou, John, Xu, Xun

“…Highlights • Next generation sequencing has transformed the approach to genetic disease diagnosis. • Mitochondrial dysfunction may confound the diagnosis of…”
Get full text