Search Results - "Andrew Pocklington"

Novel Findings from CNVs Implicate Inhibitory and Excitatory Signaling Complexes in Schizophrenia by Pocklington, Andrew J., Rees, Elliott, Walters, James T.R., Han, Jun, Kavanagh, David H., Chambert, Kimberly D., Holmans, Peter, Moran, Jennifer L., McCarroll, Steven A., Kirov, George, O’Donovan, Michael C., Owen, Michael J.

“…We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the association between the disorder and chromosomal copy number (CNV) burden…”
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Dual-Element, Two-Dimensional Atom Array with Continuous-Mode Operation by Singh, Kevin, Anand, Shraddha, Pocklington, Andrew, Kemp, Jordan T., Bernien, Hannes

“…Quantum processing architectures that include multiple qubit modalities offer compelling strategies for high-fidelity operations and readout, quantum error…”
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Universal Time-Entanglement Trade-Off in Open Quantum Systems by Pocklington, Andrew, Clerk, Aashish A.

“…We demonstrate a surprising connection between pure steady-state entanglement and relaxation time scales in an extremely broad class of Markovian open systems,…”
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Novel Insight Into the Etiology of Autism Spectrum Disorder Gained by Integrating Expression Data With Genome-wide Association Statistics by Pain, Oliver, Pocklington, Andrew J., Holmans, Peter A., Bray, Nicholas J., O’Brien, Heath E., Hall, Lynsey S., Pardiñas, Antonio F., O’Donovan, Michael C., Owen, Michael J., Anney, Richard

“…A recent genome-wide association study (GWAS) of autism spectrum disorder (ASD) (ncases = 18,381, ncontrols = 27,969) has provided novel opportunities for…”
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Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism by Pardiñas, Antonio F, Nalmpanti, Mariana, Pocklington, Andrew J, Legge, Sophie E, Medway, Christopher, King, Adrian, Jansen, John, Helthuis, Marinka, Zammit, Stanley, MacCabe, James, Owen, Michael J, O’Donovan, Michael C, Walters, James T.R

“…Objective:Clozapine is the only effective medication for treatment-resistant schizophrenia, but its worldwide use is still limited because of its complex…”
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Biological Overlap of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: Evidence From Copy Number Variants by Martin, Joanna, BSc, Cooper, Miriam, MRCPsych, MSc, Hamshere, Marian L., PhD, Pocklington, Andrew, PhD, Scherer, Stephen W., PhD, FRSC, Kent, Lindsey, MD, PhD, Gill, Michael, MD, MRCPsych, Owen, Michael J., FRCPsych, PhD, Williams, Nigel, PhD, O'Donovan, Michael C., FRCPsych, PhD, Thapar, Anita, FRCPsych, PhD, Holmans, Peter, PhD

“…Objective Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur and share genetic risks. The aim of this analysis…”
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The synapse in schizophrenia by Pocklington, Andrew J., O'Donovan, Michael, Owen, Michael J.

“…It has been several decades since synaptic dysfunction was first suggested to play a role in schizophrenia, but only in the last few years has convincing…”
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Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants by Sanders, Bret, D’Andrea, Daniel, Collins, Mark O., Rees, Elliott, Steward, Tom G. J., Zhu, Ying, Chapman, Gareth, Legge, Sophie E., Pardiñas, Antonio F., Harwood, Adrian J., Gray, William P., O’Donovan, Michael C., Owen, Michael J., Errington, Adam C., Blake, Derek J., Whitcomb, Daniel J., Pocklington, Andrew J., Shin, Eunju

“…Coordinated programs of gene expression drive brain development. It is unclear which transcriptional programs, in which cell-types, are affected in…”
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Genetic association of FMRP targets with psychiatric disorders by Clifton, Nicholas E., Rees, Elliott, Holmans, Peter A., Pardiñas, Antonio F., Harwood, Janet C., Di Florio, Arianna, Kirov, George, Walters, James T. R., O’Donovan, Michael C., Owen, Michael J., Hall, Jeremy, Pocklington, Andrew J.

“…Genes encoding the mRNA targets of fragile X mental retardation protein (FMRP) are enriched for genetic association with psychiatric disorders. However, many…”
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Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis by Rees, Elliott, Carrera, Noa, Morgan, Joanne, Hambridge, Kirsty, Escott-Price, Valentina, Pocklington, Andrew J., Richards, Alexander L., Pardiñas, Antonio F., Alizadeh, Behrooz Z., van Amelsvoort, Therese, Bartels-Velthuis, Agna A., van Beveren, Nico J., Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Delespaul, Philippe, Meijer, Carin J., Myin-Germeys, Inez, Kahn, Rene S., Schirmbeck, Frederike, Simons, Claudia J.P., van Haren, Neeltje E., van Os, Jim, van Winkel, Ruud, Luykx, Jurjen J., McDonald, Colm, Donohoe, Gary, Morris, Derek W., Kenny, Elaine, Kelleher, Eric, Gill, Michael, Corvin, Aiden, Kirov, George, Walters, James T.R., Holmans, Peter, Owen, Michael J., O’Donovan, Michael C.

“…Sequencing studies have pointed to the involvement in schizophrenia of rare coding variants in neuronally expressed genes, including activity-regulated…”
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Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development by Phillips, Tom J., Scott, Hannah, Menassa, David A., Bignell, Ashleigh L., Sood, Aman, Morton, Jude S., Akagi, Takami, Azuma, Koki, Rogers, Mark F., Gilmore, Catherine E., Inman, Gareth J., Grant, Simon, Chung, Yealin, Aljunaidy, Mais M., Cooke, Christy-Lynn, Steinkraus, Bruno R., Pocklington, Andrew, Logan, Angela, Collett, Gavin P., Kemp, Helena, Holmans, Peter A., Murphy, Michael P., Fulga, Tudor A., Coney, Andrew M., Akashi, Mitsuru, Davidge, Sandra T., Case, C. Patrick

“…Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental…”
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Evolutionary expansion and anatomical specialization of synapse proteome complexity by Grant, Seth G N, Emes, Richard D, Pocklington, Andrew J, Anderson, Christopher N G, Bayes, Alex, Collins, Mark O, Vickers, Catherine A, Croning, Mike D R, Malik, Bilal R, Choudhary, Jyoti S, Armstrong, J Douglas

“…Grant and colleagues used comparative proteomics and genomics to examine the evolution of the postsynaptic density and MAGUK-associated signaling complexes…”
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Dynamic expression of genes associated with schizophrenia and bipolar disorder across development by Clifton, Nicholas E., Hannon, Eilís, Harwood, Janet C., Di Florio, Arianna, Thomas, Kerrie L., Holmans, Peter A., Walters, James T. R., O’Donovan, Michael C., Owen, Michael J., Pocklington, Andrew J., Hall, Jeremy

“…Common genetic variation contributes a substantial proportion of risk for both schizophrenia and bipolar disorder. Furthermore, there is evidence of…”
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De novo mutations in schizophrenia implicate synaptic networks by Fromer, Menachem, Pocklington, Andrew J., Kavanagh, David H., Williams, Hywel J., Dwyer, Sarah, Gormley, Padhraig, Georgieva, Lyudmila, Rees, Elliott, Palta, Priit, Ruderfer, Douglas M., Carrera, Noa, Humphreys, Isla, Johnson, Jessica S., Roussos, Panos, Barker, Douglas D., Banks, Eric, Milanova, Vihra, Grant, Seth G., Hannon, Eilis, Rose, Samuel A., Chambert, Kimberly, Mahajan, Milind, Scolnick, Edward M., Moran, Jennifer L., Kirov, George, Palotie, Aarno, McCarroll, Steven A., Holmans, Peter, Sklar, Pamela, Owen, Michael J., Purcell, Shaun M., O’Donovan, Michael C.

“…Inherited alleles account for most of the genetic risk for schizophrenia. However, new ( de novo ) mutations, in the form of large chromosomal copy number…”
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Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort by Grama, Steluta, Willcocks, Isabella, Hubert, John J., Pardiñas, Antonio F., Legge, Sophie E., Bracher-Smith, Matthew, Menzies, Georgina E., Hall, Lynsey S., Pocklington, Andrew J., Anney, Richard J. L., Bray, Nicholas J., Escott-Price, Valentina, Caseras, Xavier

“…Research has shown differences in subcortical brain volumes between participants with schizophrenia and healthy controls. However, none of these differences…”
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Neurotransmitters drive combinatorial multistate postsynaptic density networks by Coba, Marcelo P, Pocklington, Andrew J, Collins, Mark O, Kopanitsa, Maksym V, Uren, Rachel T, Swamy, Sajani, Croning, Mike D R, Choudhary, Jyoti S, Grant, Seth G N

“…The mammalian postsynaptic density (PSD) comprises a complex collection of approximately 1100 proteins. Despite extensive knowledge of individual proteins, the…”
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The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour by Grant, Seth G N, Pocklington, Andrew J, Cumiskey, Mark, Armstrong, J Douglas

“…Neuronal synapses play fundamental roles in information processing, behaviour and disease. Neurotransmitter receptor complexes, such as the mammalian…”
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Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder by Frank, René A W, McRae, Allan F, Pocklington, Andrew J, van de Lagemaat, Louie N, Navarro, Pau, Croning, Mike D R, Komiyama, Noboru H, Bradley, Sophie J, Challiss, R A John, Armstrong, J Douglas, Finn, Robert D, Malloy, Mary P, MacLean, Alan W, Harris, Sarah E, Starr, John M, Bhaskar, Sanjeev S, Howard, Eleanor K, Hunt, Sarah E, Coffey, Alison J, Ranganath, Venkatesh, Deloukas, Panos, Rogers, Jane, Muir, Walter J, Deary, Ian J, Blackwood, Douglas H, Visscher, Peter M, Grant, Seth G N

“…Current models of schizophrenia and bipolar disorder implicate multiple genes, however their biological relationships remain elusive. To test the genetic role…”
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Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects by Erk, Susanne, Meyer-Lindenberg, Andreas, Linden, David E.J., Lancaster, Thomas, Mohnke, Sebastian, Grimm, Oliver, Degenhardt, Franziska, Holmans, Peter, Pocklington, Andrew, Schmierer, Phöbe, Haddad, Leila, Mühleisen, Thomas W., Mattheisen, Manuel, Witt, Stephanie H., Romanczuk-Seiferth, Nina, Tost, Heike, Schott, Björn H., Cichon, Sven, Nöthen, Markus M., Rietschel, Marcella, Heinz, Andreas, Walter, Henrik

“…Variation in the CACNA1C gene has consistently been associated with psychosis in genome wide association studies. We have previously shown in a sample of n=110…”
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Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence by Fernández, Esperanza, Collins, Mark O., Frank, René A.W., Zhu, Fei, Kopanitsa, Maksym V., Nithianantharajah, Jess, Lemprière, Sarah A., Fricker, David, Elsegood, Kathryn A., McLaughlin, Catherine L., Croning, Mike D.R., Mclean, Colin, Armstrong, J. Douglas, Hill, W. David, Deary, Ian J., Cencelli, Giulia, Bagni, Claudia, Fromer, Menachem, Purcell, Shaun M., Pocklington, Andrew J., Choudhary, Jyoti S., Komiyama, Noboru H., Grant, Seth G.N.

“…Arc is an activity-regulated neuronal protein, but little is known about its interactions, assembly into multiprotein complexes, and role in human disease and…”
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