Search Results - "Andrew P. Bradford"

DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination by Korch, Christopher, Spillman, Monique A, Jackson, Twila A, Jacobsen, Britta M, Murphy, Susan K, Lessey, Bruce A, Jordan, V. Craig, Bradford, Andrew P

“…Abstract Objectives Cell lines derived from human ovarian and endometrial cancers, and their immortalized non-malignant counterparts, are critical tools to…”
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A randomized clinical trial demonstrating cell type specific effects of hyperlipidemia and hyperinsulinemia on pituitary function by McDonald, Rosemary, Kuhn, Katherine, Nguyen, Thy B, Tannous, Andrew, Schauer, Irene, Santoro, Nanette, Bradford, Andrew P

“…Obesity is characterized by elevated lipids, insulin resistance and relative hypogonadotropic hypogonadism, reducing fertility and increasing risk of pregnancy…”
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A randomised trial examining inflammatory signaling in acutely induced hyperinsulinemia and hyperlipidemia in normal weight women-the reprometabolic syndrome by Tannous, Andrew, Bradford, Andrew P, Kuhn, Katherine, Fought, Angela, Schauer, Irene, Santoro, Nanette

“…Obesity, is a state of chronic inflammation, characterized by elevated lipids, insulin resistance and relative hypogonadotropic hypogonadism. We have defined…”
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Characterization of the uterine leiomyoma microRNAome by deep sequencing by Georgieva, Boryana, Milev, Ivan, Minkov, Ivan, Dimitrova, Irina, Bradford, Andrew P., Baev, Vesselin

“…MicroRNAs (miRNAs) are a class of small non-coding RNAs, which are negative regulators of gene expression. Many genes in human uterine leiomyoma (ULM) are…”
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Deregulated E2F Activity as a Cancer-Cell Specific Therapeutic Tool by Nakajima, Rinka, Zhao, Lin, Zhou, Yaxuan, Shirasawa, Mashiro, Uchida, Ayato, Murakawa, Hikaru, Fikriyanti, Mariana, Iwanaga, Ritsuko, Bradford, Andrew P, Araki, Keigo, Warita, Tomoko, Ohtani, Kiyoshi

“…The transcription factor E2F, the principal target of the tumor suppressor pRB, plays crucial roles in cell proliferation and tumor suppression. In almost all…”
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Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes by Komori, Hideyuki, Goto, Yasuko, Kurayoshi, Kenta, Ozono, Eiko, Iwanaga, Ritsuko, Bradford, Andrew P., Araki, Keigo, Ohtani, Kiyoshi

“…The transcription factor E2F plays crucial roles in cell proliferation and tumor suppression by activating growth-related genes and pro-apoptotic tumor…”
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Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression by Zhou, Yaxuan, Nakajima, Rinka, Shirasawa, Mashiro, Fikriyanti, Mariana, Zhao, Lin, Iwanaga, Ritsuko, Bradford, Andrew P, Kurayoshi, Kenta, Araki, Keigo, Ohtani, Kiyoshi

“…The transcription factor E2F links the RB pathway to the p53 pathway upon loss of function of pRB, thereby playing a pivotal role in the suppression of…”
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Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways by Iwanaga, Ritsuko, Wang, Chu-An, Micalizzi, Douglas S, Harrell, J Chuck, Jedlicka, Paul, Sartorius, Carol A, Kabos, Peter, Farabaugh, Susan M, Bradford, Andrew P, Ford, Heide L

“…Mammary-specific overexpression of Six1 in mice induces tumors that resemble human breast cancer, some having undergone epithelial to mesenchymal transition…”
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Ectopic expression of the CDK inhibitor p21 Cip1 enhances deregulated E2F activity and increases cancer cell-specific cytotoxic gene expression mediated by the ARF tumor suppressor promoter by Kurayoshi, Kenta, Shiromoto, Ayumi, Ozono, Eiko, Iwanaga, Ritsuko, Bradford, Andrew P, Araki, Keigo, Ohtani, Kiyoshi

“…In cancer treatment, specifically targeting cancer cells is important for optimal therapeutic efficacy. One strategy is to utilize a cancer specific promoter…”
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Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain by Bradford, Andrew P, Jones, Kenneth, Kechris, Katerina, Chosich, Justin, Montague, Michael, Warren, Wesley C, May, Margaret C, Al-Safi, Zain, Kuokkanen, Satu, Appt, Susan E, Polotsky, Alex J

“…Obese women exhibit decreased fertility, high miscarriage rates and dysfunctional corpus luteum (CL), but molecular mechanisms are poorly defined. We…”
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Cancer cell specific cytotoxic gene expression mediated by ARF tumor suppressor promoter constructs by Kurayoshi, Kenta, Ozono, Eiko, Iwanaga, Ritsuko, Bradford, Andrew P., Komori, Hideyuki, Ohtani, Kiyoshi

“…•ARF promoter showed higher responsiveness to deregulated E2F activity than the E2F1 promoter.•ARF promoter showed higher cancer cell-specificity than E2F1…”
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Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts by Kitamura, Hodaka, Ozono, Eiko, Iwanaga, Ritsuko, Bradford, Andrew P., Okuno, Junko, Shimizu, Emi, Kurayoshi, Kenta, Kugawa, Kazuyuki, Toh, Hiroyuki, Ohtani, Kiyoshi

“…The transcription factor E2F is the principal target of the tumor suppressor pRB. E2F plays crucial roles not only in cell proliferation by activating…”
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Protein kinase C alpha (PKCα) regulates growth and invasion of endometrial cancer cells by Haughian, James M., Bradford, Andrew P.

“…The etiology of endometrial cancers remains poorly understood, particularly with respect to signal transduction pathways underlying the development and…”
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Protein kinase C alpha‐dependent signaling mediates endometrial cancer cell growth and tumorigenesis by Haughian, James M., Reno, Elaine M., Thorne, Alicia M., Bradford, Andrew P.

“…Endometrial cancer is the most common invasive gynecologic malignancy, yet molecular mechanisms and signaling pathways underlying its etiology and…”
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Reply of the authors: evaluating the hormonal impact of high-fat diets: gaps in gonadotropin and adrenocorticotropic hormone responses and the need for detailed fat composition analysis by Bradford, Andrew P., Nguyen, Thy, Kuhn, Katherine, Santoro, Nanette

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Effects of a eucaloric high-fat diet on anterior pituitary hormones and adipocytokines in women with normal weight by Nguyen, Thy, Kuhn, Katherine, Fought, Angela, Bolt, Matthew, Bradford, Andrew P., Santoro, Nanette

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Analysis of protein kinase C delta (PKC δ ) expression in endometrial tumors by Reno, Elaine M., BS, Haughian, James M., MS, Dimitrova, Irina K., MD, Jackson, Twila A., PhD, Shroyer, Kenneth R., PhD, Bradford, Andrew P., MD, PhD

“…Summary Endometrial cancer is the most common gynecologic malignancy in the United States. However, its underlying molecular mechanisms are poorly understood;…”
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Aromatase inhibition causes increased amplitude, but not frequency, of hypothalamic-pituitary output in normal women by Kucherov, Alexander, B.A, Polotsky, Alex J., M.S., M.D, Menke, Marie, M.D, Isaac, Barbara, R.N, McAvey, Beth, M.D, Buyuk, Erkan, M.D, Bradford, Andrew P., Ph.D, Hickmon, Cheryl, B.S, Babbs, Beatrice, B.A, Berga, Sarah, M.D, Loucks, Tammy, M.P.H, Santoro, Nanette, M.D

“…Objective To better understand the site and mode of action of aromatase inhibitors. Design Prospective study. Setting Academic research environment. Patient(s)…”
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Acceptability and Feasibility of Initiating a Low Fat Eating Plan in Reproductive Aged Women with Obesity by Santoro, Nanette, Hendricks, Nicola, Gibbs, Lauren, Kuhn, Katherine, Bradford, Andrew P, Mitchell-Leef, Dorothy

“…Adverse effects of obesity on reproduction are believed in part due to diet related factors leading to hyperlipidemia and hyperinsulinemia. It is unknown…”
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Gonadotropin response to insulin and lipid infusion reproduces the reprometabolic syndrome of obesity in eumenorrheic lean women: a randomized crossover trial by Santoro, Nanette, Schauer, Irene E., Kuhn, Katherine, Fought, Angela J., Babcock-Gilbert, Sara, Bradford, Andrew P.

“…To study the reprometabolic syndrome in normal-weight, eumenorrheic women by infusing a combination of insulin and lipid. Women with obesity have been shown to…”
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