Search Results - "Andrew Livingston, J."
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Immuno-genomic landscape of osteosarcoma
Published in Nature communications (21-02-2020)“…Limited clinical activity has been seen in osteosarcoma (OS) patients treated with immune checkpoint inhibitors (ICI). To gain insights into the immunogenic…”
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Prediction of biomarkers and therapeutic combinations for anti-PD-1 immunotherapy using the global gene network association
Published in Nature communications (10-01-2022)“…Owing to a lack of response to the anti-PD1 therapy for most cancer patients, we develop a network approach to infer genes, pathways, and potential therapeutic…”
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Specific, reversible G1 arrest by UCN-01 in vivo provides cytostatic protection of normal cells against cytotoxic chemotherapy in breast cancer
Published in British journal of cancer (17-03-2020)“…Background Low-dose UCN-01 mediates G1 arrest in normal proliferating cell lines with an intact G1 to S transition but not tumour cells with a deregulated G1…”
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Factors impacting adolescent and young adult cancer patients’ decision to pursue genetic counseling and testing
Published in Supportive care in cancer (01-06-2022)“…Purpose Adolescent and young adult (AYA) cancer patients face challenges when navigating cancer treatment and survivorship. Many are at risk for cancer…”
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Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma
Published in Cell reports (Cambridge) (26-01-2021)“…Osteosarcoma is the most common pediatric and adult primary malignant bone cancer. Curative regimens target the folate pathway, downstream of serine…”
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Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing
Published in BMC cancer (31-05-2023)“…Single-cell RNA-seq has emerged as an innovative technology used to study complex tissues and characterize cell types, states, and lineages at a single-cell…”
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Analysis of HSP27 and the Autophagy Marker LC3B + Puncta Following Preoperative Chemotherapy Identifies High-Risk Osteosarcoma Patients
Published in Molecular cancer therapeutics (01-06-2018)“…Chemotherapy-induced autophagy is a proposed mechanism of chemoresistance and potential therapeutic target in osteosarcoma. We evaluated heat shock protein 27…”
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Early skeletal muscle loss in adolescent and young adult cancer patients treated with anthracycline chemotherapy
Published in Cancer medicine (Malden, MA) (01-11-2023)“…Background Early skeletal muscle loss has been observed in adolescent and young adult (AYA) sarcoma patients undergoing treatment. Identification of…”
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Associations Between Stress, Health Behaviors, and Quality of Life in Young Couples During the Transition to Survivorship: Protocol for a Measurement Burst Study
Published in JMIR research protocols (23-04-2024)“…Cancer is a life-threatening, stressful event, particularly for young adults due to delays and disruptions in their developmental transitions. Cancer treatment…”
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Successful treatment of lipofibromatosis-like neural tumor of the lumbar spine with an NTRK-fusion inhibitor
Published in Clinical sarcoma research (06-08-2020)“…Lipofibromatosis-like neural tumors (LPF-NT) are a newly identified class of rare mesenchymal neoplasms. Current standard of care therapy is surgical resection…”
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Validation of prognostic scoring and assessment of clinical benefit for patients with bone sarcomas enrolled in phase I clinical trials
Published in Oncotarget (27-09-2016)“…We sought to validate the Royal Marsden Hospital (RMH) and MD Anderson Cancer Center (MDACC) prognostic scoring systems for the selection of bone sarcoma…”
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Patient‐reported quality of life in adolescents and young adults with cancer who received radiation therapy
Published in Cancer medicine (Malden, MA) (01-07-2023)“…Background Radiation therapy (RT) is a common treatment for adolescents and young adults (AYAs, 15–39 years old) with cancer; however, it may cause toxicities…”
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Clinical characteristics and outcomes of adult alveolar rhabdomyosarcoma patients on first-line systemic therapies: A single-institution cohort
Published in Rare tumors (01-07-2024)“…Rhabdomyosarcomas are the most common soft tissue sarcoma in children, and pediatric alveolar rhabdomyosarcoma (ARMS) prognosis has improved based on…”
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PET/CT Imaging as a Diagnostic Tool in Distinguishing Well-Differentiated versus Dedifferentiated Liposarcoma
Published in Complexity (New York, N.Y.) (2020)“…Distinguishing well-differentiated liposarcoma (WDLPS) from dedifferentiated liposarcoma (DDLPS) is essential given distinct treatment paradigms and…”
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Hypofractionated Radiation Therapy for Unresectable or Metastatic Sarcoma Lesions
Published in Advances in radiation oncology (01-05-2022)“…Given the relative radioresistance of sarcomas and their often large size, conventional palliative radiation therapy (RT) often offers limited tumor control…”
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Osteosarcoma
Published in Nature reviews. Disease primers (08-12-2022)“…Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma incidence is bimodal, peaking at 18 and 60 years of age, and is slightly…”
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Improved survival and decreased cancer deaths in young adults with cancer after passage of the Affordable Care Act Dependent Coverage Expansion
Published in Cancer (07-10-2024)“…The Patient Protection and Affordable Care Act (ACA) allowed Americans aged 19-25 years to remain on their parents' health insurance plans until age 26 years…”
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Genomics and the Immune Landscape of Osteosarcoma
Published in Advances in experimental medicine and biology (01-01-2020)“…Conventional osteosarcoma (OS) is a high-grade intraosseous malignancy with production of osteoid matrix; however, a deeper dive into the underlying genetics…”
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Impact of Race, Ethnicity, and Socioeconomic Status over Time on the Long-term Survival of Adolescent and Young Adult Hodgkin Lymphoma Survivors
Published in Cancer epidemiology, biomarkers & prevention (01-09-2021)“…Although there are growing numbers of adolescent and young adult (AYA) Hodgkin lymphoma (HL) survivors, long-term overall survival (OS) patterns and…”
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Improved Survival of Young Adults with Cancer Following the Passage of the Affordable Care Act
Published in The oncologist (Dayton, Ohio) (04-03-2022)“…Compared with their ensured counterparts, uninsured adolescents and young adults (AYAs) with cancer are more likely to present with advanced disease and have…”
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