Search Results - "Andrew J. Lees"

Prognosis and Neuropathologic Correlation of Clinical Subtypes of Parkinson Disease by De Pablo-Fernández, Eduardo, Lees, Andrew J, Holton, Janice L, Warner, Thomas T

“…Clinical subtyping of Parkinson disease at diagnosis is useful in estimating disease course and survival. Severity and rate of progression of neuropathologies…”
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Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges by Williams, David R, FRACP, Lees, Andrew J, FRCP

“…Summary Progressive supranuclear palsy (PSP) is a clinical syndrome comprising supranuclear palsy, postural instability, and mild dementia…”
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Meta-analysis of early nonmotor features and risk factors for Parkinson disease by Noyce, Alastair J., Bestwick, Jonathan P., Silveira-Moriyama, Laura, Hawkes, Christopher H., Giovannoni, Gavin, Lees, Andrew J., Schrag, Anette

“…Objective: To evaluate the association between diagnosis of Parkinson disease (PD) and risk factors or early symptoms amenable to population‐based screening…”
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Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions by Magdalinou, Nadia, Lees, Andrew J, Zetterberg, Henrik

“…Parkinsonian diseases comprise a heterogeneous group of neurodegenerative disorders, which show significant clinical and pathological overlap. Accurate…”
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Fiber-specific white matter reductions in Parkinson hallucinations and visual dysfunction by Zarkali, Angeliki, McColgan, Peter, Leyland, Louise-Ann, Lees, Andrew J., Rees, Geraint, Weil, Rimona S.

“…OBJECTIVETo investigate the microstructural and macrostructural white matter changes that accompany visual hallucinations and low visual performance in…”
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Four pioneers of L-dopa treatment: Arvid Carlsson, Oleh Hornykiewicz, George Cotzias, and Melvin Yahr by Lees, Andrew J., Tolosa, Eduardo, Olanow, C. Warren

“…ABSTRACT Four individuals stand out as pioneers of the early work that led to levodopa becoming a revolutionary new treatment for Parkinson's disease: Arvid…”
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Alpha-synuclein mRNA expression in oligodendrocytes in MSA by Asi, Yasmine T., Simpson, Julie E., Heath, Paul R., Wharton, Stephen B., Lees, Andrew J., Revesz, Tamas, Houlden, Henry, Holton, Janice L.

“…Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting clinically with parkinsonian, cerebellar, and autonomic features…”
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Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study by Noyce, Alastair J, Kia, Demis A, Hemani, Gibran, Nicolas, Aude, Price, T Ryan, De Pablo-Fernandez, Eduardo, Haycock, Philip C, Lewis, Patrick A, Foltynie, Thomas, Davey Smith, George, Schrag, Anette, Lees, Andrew J, Hardy, John, Singleton, Andrew, Nalls, Mike A, Pearce, Neil, Lawlor, Debbie A, Wood, Nicholas W

“…Both positive and negative associations between higher body mass index (BMI) and Parkinson disease (PD) have been reported in observational studies, but it has…”
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Bone health in Parkinson's disease: a systematic review and meta-analysis by Torsney, Kelli M, Noyce, Alastair J, Doherty, Karen M, Bestwick, Jonathan P, Dobson, Ruth, Lees, Andrew J

“…Parkinson's disease (PD) and osteoporosis are chronic diseases associated with increasing age. Single studies have reported associations between them and the…”
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α-Synuclein fate is determined by USP9X-regulated monoubiquitination by Rott, Ruth, Szargel, Raymonde, Haskin, Joseph, Bandopadhyay, Rina, Lees, Andrew J, Shani, Vered, Engelender, Simone

“…α-Synuclein is central to the pathogenesis of Parkinson disease (PD). Mutations as well as accumulation of α-synuclein promote the death of dopaminergic…”
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Hypokinesia without decrement distinguishes progressive supranuclear palsy from Parkinson's disease by HELEN LING, MASSEY, Luke A, LEES, Andrew J, BROWN, Peter, DAY, Brian L

“…Repetitive finger tapping is commonly used to assess bradykinesia in Parkinson's disease. The Queen Square Brain Bank diagnostic criterion of Parkinson's…”
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Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia by Rylander, Daniella, Parent, Martin, O'Sullivan, Sean S., Dovero, Sandra, Lees, Andrew J., Bezard, Erwan, Descarries, Laurent, Cenci, M. Angela

“…Objective: Striatal serotonin projections have been implicated in levodopa‐induced dyskinesia by providing an unregulated source of dopamine release. We set…”
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Donepezil in Parkinson's disease dementia: A randomized, double-blind efficacy and safety study by Dubois, Bruno, Tolosa, Eduardo, Katzenschlager, Regina, Emre, Murat, Lees, Andrew J., Schumann, Günther, Pourcher, Emmanuelle, Gray, Julian, Thomas, Gail, Swartz, Jina, Hsu, Timothy, Moline, Margaret L.

“…Parkinson's disease dementia (PDD) is associated with cholinergic deficits. This report presents an efficacy and safety study of the acetylcholinesterase…”
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Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy by Massey, Luke A., Micallef, Caroline, Paviour, Dominic C., O'Sullivan, Sean S., Ling, Helen, Williams, David R., Kallis, Constantinos, Holton, Janice L., Revesz, Tamas, Burn, David J., Yousry, Tarek, Lees, Andrew J., Fox, Nick C., Jäger, Hans R.

“…Conventional magnetic resonance imaging (cMRI) is often used to aid the diagnosis of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA),…”
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Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome by Williams, David R., Holton, Janice L., Strand, Catherine, Pittman, Alan, de Silva, Rohan, Lees, Andrew J., Revesz, Tamas

“…Clinical syndromes associated with progressive supranuclear palsy-tau pathology now include progressive supranuclear palsy-parkinsonism (PSP-P), in addition to…”
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What features improve the accuracy of the clinical diagnosis of progressive supranuclear palsy-parkinsonism (PSP-P)? by Williams, David R, Lees, Andrew J

“…Progressive supranuclear palsy‐parkinsonism (PSP‐P) is a primary tauopathy characterised by neurofibrillary degeneration, which is frequently mistaken for…”
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Validation of the MDS-UPDRS Part I for nonmotor symptoms in Parkinson's disease by Gallagher, David A., Goetz, Christopher G., Stebbins, Glenn, Lees, Andrew J., Schrag, Anette

“…The UPDRS has been the main outcome measure in studies of PD. Modifications have been made to improve scale properties and represent the breadth of…”
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Visual hallucinations in the diagnosis of idiopathic Parkinson's disease: a retrospective autopsy study by Williams, David R, Lees, Andrew J

“…For many years, visual hallucinations (VH) in idiopathic Parkinson's disease (PD) were thought to be a complication of antiparkinsonian treatment. The cause of…”
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Identification of multiple system atrophy mimicking Parkinson's disease or progressive supranuclear palsy by Miki, Yasuo, Tsushima, Eiki, Foti, Sandrine C, Strand, Kate M, Asi, Yasmine T, Yamamoto, Adam Kenji, Bettencourt, Conceição, Oliveira, Marcos C B, De Pablo-Fernández, Eduardo, Jaunmuktane, Zane, Lees, Andrew J, Wakabayashi, Koichi, Warner, Thomas T, Quinn, Niall, Holton, Janice L, Ling, Helen

“…We studied a subset of patients with autopsy-confirmed multiple system atrophy who presented a clinical picture that closely resembled either Parkinson's…”
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Identification and Quantification of Oligodendrocyte Precursor Cells in Multiple System Atrophy, Progressive Supranuclear Palsy and Parkinson's Disease by Ahmed, Zeshan, Asi, Yasmine T., Lees, Andrew J., Revesz, Tamas, Holton, Janice L.

“…Multiple system atrophy is a neurodegenerative disorder characterized pathologically by abnormal accumulations of α‐synuclein in the cytoplasm of…”
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