Search Results - "Andrew Futreal, P"

Emerging patterns of somatic mutations in cancer by Watson, Ian R., Takahashi, Koichi, Futreal, P. Andrew, Chin, Lynda

“…Key Points The emergence of next-generation sequencing technology has made important contributions to our understanding of cancer genomes. In this Review, we…”
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Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics by Morita, Kiyomi, Wang, Feng, Jahn, Katharina, Hu, Tianyuan, Tanaka, Tomoyuki, Sasaki, Yuya, Kuipers, Jack, Loghavi, Sanam, Wang, Sa A., Yan, Yuanqing, Furudate, Ken, Matthews, Jairo, Little, Latasha, Gumbs, Curtis, Zhang, Jianhua, Song, Xingzhi, Thompson, Erika, Patel, Keyur P., Bueso-Ramos, Carlos E., DiNardo, Courtney D., Ravandi, Farhad, Jabbour, Elias, Andreeff, Michael, Cortes, Jorge, Bhalla, Kapil, Garcia-Manero, Guillermo, Kantarjian, Hagop, Konopleva, Marina, Nakada, Daisuke, Navin, Nicholas, Beerenwinkel, Niko, Futreal, P. Andrew, Takahashi, Koichi

“…Clonal diversity is a consequence of cancer cell evolution driven by Darwinian selection. Precise characterization of clonal architecture is essential to…”
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Prediction of biomarkers and therapeutic combinations for anti-PD-1 immunotherapy using the global gene network association by Wu, Chia-Chin, Wang, Y. Alan, Livingston, J. Andrew, Zhang, Jianhua, Futreal, P. Andrew

“…Owing to a lack of response to the anti-PD1 therapy for most cancer patients, we develop a network approach to infer genes, pathways, and potential therapeutic…”
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Cancer genomics: from discovery science to personalized medicine by Chin, Lynda, Andersen, Jannik N, Futreal, P Andrew

“…Recent advances in genome technologies and the ensuing outpouring of genomic information related to cancer have accelerated the convergence of discovery…”
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Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia by Wang, Feng, Morita, Kiyomi, DiNardo, Courtney D., Furudate, Ken, Tanaka, Tomoyuki, Yan, Yuanqing, Patel, Keyur P., MacBeth, Kyle J., Wu, Bin, Liu, Guowen, Frattini, Mark, Matthews, Jairo A., Little, Latasha D., Gumbs, Curtis, Song, Xingzhi, Zhang, Jianhua, Thompson, Erika J., Kadia, Tapan M., Garcia-Manero, Guillermo, Jabbour, Elias, Ravandi, Farhad, Bhalla, Kapil N., Konopleva, Marina, Kantarjian, Hagop M., Andrew Futreal, P., Takahashi, Koichi

“…Allosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant leukemic blasts and provide durable clinical responses in…”
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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing by Gerlinger, Marco, Rowan, Andrew J, Horswell, Stuart, Larkin, James, Endesfelder, David, Gronroos, Eva, Martinez, Pierre, Matthews, Nicholas, Stewart, Aengus, Tarpey, Patrick, Varela, Ignacio, Phillimore, Benjamin, Begum, Sharmin, McDonald, Neil Q, Butler, Adam, Jones, David, Raine, Keiran, Latimer, Calli, Santos, Claudio R, Nohadani, Mahrokh, Eklund, Aron C, Spencer-Dene, Bradley, Clark, Graham, Pickering, Lisa, Stamp, Gordon, Gore, Martin, Szallasi, Zoltan, Downward, Julian, Futreal, P. Andrew, Swanton, Charles

“…Genetic analysis was applied to different regions of renal-cell cancers. The lesions noted in the tumor were not found in every sample, and regions of the…”
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Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer by Jia, Qingzhu, Wu, Wei, Wang, Yuqi, Alexander, Peter B., Sun, Chengdu, Gong, Zhihua, Cheng, Jia-Nan, Sun, Huaibo, Guan, Yanfang, Xia, Xuefeng, Yang, Ling, Yi, Xin, Wan, Yisong Y., Wang, Haidong, He, Ji, Futreal, P. Andrew, Li, Qi-Jing, Zhu, Bo

“…Combining whole exome sequencing, transcriptome profiling, and T cell repertoire analysis, we investigate the spatial features of surgically-removed biopsies…”
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Preleukaemic clonal haemopoiesis and risk of therapy-related myeloid neoplasms: a case-control study by Takahashi, Koichi, MD, Wang, Feng, PhD, Kantarjian, Hagop, Prof, Doss, Denaha, MS, Khanna, Kanhav, MS, Thompson, Erika, MS, Zhao, Li, PhD, Patel, Keyur, MD, Neelapu, Sattva, MD, Gumbs, Curtis, BS, Bueso-Ramos, Carlos, Prof, DiNardo, Courtney D, MD, Colla, Simona, PhD, Ravandi, Farhad, Prof, Zhang, Jianhua, PhD, Huang, Xuelin, PhD, Wu, Xifeng, Prof, Samaniego, Felipe, MD, Garcia-Manero, Guillermo, Prof, Futreal, P Andrew, Prof

“…Summary Background Therapy-related myeloid neoplasms are secondary malignancies that are often fatal, but their risk factors are not well understood. Evidence…”
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Immuno-genomic landscape of osteosarcoma by Wu, Chia-Chin, Beird, Hannah C., Andrew Livingston, J., Advani, Shailesh, Mitra, Akash, Cao, Shaolong, Reuben, Alexandre, Ingram, Davis, Wang, Wei-Lien, Ju, Zhenlin, Hong Leung, Cheuk, Lin, Heather, Zheng, Youyun, Roszik, Jason, Wang, Wenyi, Patel, Shreyaskumar, Benjamin, Robert S., Somaiah, Neeta, Conley, Anthony P., Mills, Gordon B., Hwu, Patrick, Gorlick, Richard, Lazar, Alexander, Daw, Najat C., Lewis, Valerae, Futreal, P. Andrew

“…Limited clinical activity has been seen in osteosarcoma (OS) patients treated with immune checkpoint inhibitors (ICI). To gain insights into the immunogenic…”
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Deep sequencing of circulating tumor DNA detects molecular residual disease and predicts recurrence in gastric cancer by Yang, Jian, Gong, Yuhua, Lam, Vincent K., Shi, Yan, Guan, Yanfang, Zhang, Yanyan, Ji, Liyan, Chen, Yongsheng, Zhao, Yongliang, Qian, Feng, Chen, Jun, Li, Pingang, Zhang, Fan, Wang, Jiayin, Zhang, Xuanping, Yang, Ling, Kopetz, Scott, Futreal, P. Andrew, Zhang, Jianjun, Yi, Xin, Xia, Xuefeng, Yu, Peiwu

“…Identifying locoregional gastric cancer patients who are at high risk for relapse after resection could facilitate early intervention. By detecting molecular…”
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Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure by Akdemir, Kadir C., Le, Victoria T., Kim, Justin M., Killcoyne, Sarah, King, Devin A., Lin, Ya-Ping, Tian, Yanyan, Inoue, Akira, Amin, Samirkumar B., Robinson, Frederick S., Nimmakayalu, Manjunath, Herrera, Rafael E., Lynn, Erica J., Chan, Kin, Seth, Sahil, Klimczak, Leszek J., Gerstung, Moritz, Gordenin, Dmitry A., O’Brien, John, Li, Lei, Deribe, Yonathan Lissanu, Verhaak, Roel G., Campbell, Peter J., Fitzgerald, Rebecca, Morrison, Ashby J., Dixon, Jesse R., Andrew Futreal, P.

“…Somatic mutations in driver genes may ultimately lead to the development of cancer. Understanding how somatic mutations accumulate in cancer genomes and the…”
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Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets by Ferrarotto, Renata, Mitani, Yoshitsugu, McGrail, Daniel J, Li, Kaiyi, Karpinets, Tatiana V, Bell, Diana, Frank, Steven J, Song, Xingzhi, Kupferman, Michael E, Liu, Bin, Lee, J Jack, Glisson, Bonnie S, Zhang, Jianhua, Aster, Jon C, Lin, Shiaw-Yih, Futreal, P Andrew, Heymach, John V, El-Naggar, Adel K

“…Salivary gland adenoid cystic carcinoma (ACC) has heterogeneous clinical behavior. Currently, all patients are treated uniformly, and no standard-of-care…”
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Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells by Yang, Wanjuan, Soares, Jorge, Greninger, Patricia, Edelman, Elena J, Lightfoot, Howard, Forbes, Simon, Bindal, Nidhi, Beare, Dave, Smith, James A, Thompson, I Richard, Ramaswamy, Sridhar, Futreal, P Andrew, Haber, Daniel A, Stratton, Michael R, Benes, Cyril, McDermott, Ultan, Garnett, Mathew J

“…Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The…”
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MuSE: accounting for tumor heterogeneity using a sample-specific error model improves sensitivity and specificity in mutation calling from sequencing data by Fan, Yu, Xi, Liu, Hughes, Daniel S T, Zhang, Jianjun, Zhang, Jianhua, Futreal, P Andrew, Wheeler, David A, Wang, Wenyi

“…Subclonal mutations reveal important features of the genetic architecture of tumors. However, accurate detection of mutations in genetically heterogeneous…”
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A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia by Zeng, Andy G. X., Bansal, Suraj, Jin, Liqing, Mitchell, Amanda, Chen, Weihsu Claire, Abbas, Hussein A., Chan-Seng-Yue, Michelle, Voisin, Veronique, van Galen, Peter, Tierens, Anne, Cheok, Meyling, Preudhomme, Claude, Dombret, Hervé, Daver, Naval, Futreal, P. Andrew, Minden, Mark D., Kennedy, James A., Wang, Jean C. Y., Dick, John E.

“…The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising therapies entering clinical translation, yet patient responses remain…”
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PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy by Hsu, Joanne I., Dayaram, Tajhal, Tovy, Ayala, De Braekeleer, Etienne, Jeong, Mira, Wang, Feng, Zhang, Jianhua, Heffernan, Timothy P., Gera, Sonal, Kovacs, Jeffrey J., Marszalek, Joseph R., Bristow, Christopher, Yan, Yuanqing, Garcia-Manero, Guillermo, Kantarjian, Hagop, Vassiliou, George, Futreal, P. Andrew, Donehower, Lawrence A., Takahashi, Koichi, Goodell, Margaret A.

“…Clonal hematopoiesis (CH), in which stem cell clones dominate blood production, becomes increasingly common with age and can presage malignancy development…”
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Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations by Mitani, Yoshitsugu, Liu, Bin, Rao, Pulivarthi H, Borra, Vishnupriya J, Zafereo, Mark, Weber, Randal S, Kies, Merrill, Lozano, Guillermina, Futreal, P Andrew, Caulin, Carlos, El-Naggar, Adel K

“…Adenoid cystic carcinoma (ACC) is an indolent salivary gland malignancy, characterized by t(6;9) translocations and MYB-NFIB gene fusions in approximately 50%…”
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Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing by Zhang, Jianjun, Fujimoto, Junya, Zhang, Jianhua, Wedge, David C., Song, Xingzhi, Zhang, Jiexin, Seth, Sahil, Chow, Chi-Wan, Cao, Yu, Gumbs, Curtis, Gold, Kathryn A., Kalhor, Neda, Little, Latasha, Mahadeshwar, Harshad, Moran, Cesar, Protopopov, Alexei, Sun, Huandong, Tang, Jiabin, Wu, Xifeng, Ye, Yuanqing, William, William N., Lee, J. Jack, Heymach, John V., Hong, Waun Ki, Swisher, Stephen, Wistuba, Ignacio I., Futreal, P. Andrew

“…Cancers are composed of populations of cells with distinct molecular and phenotypic features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung…”
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Exome sequencing of liver fluke–associated cholangiocarcinoma by Ong, Choon Kiat, Subimerb, Chutima, Pairojkul, Chawalit, Wongkham, Sopit, Cutcutache, Ioana, Yu, Willie, McPherson, John R, Allen, George E, Ng, Cedric Chuan Young, Wong, Bernice Huimin, Myint, Swe Swe, Rajasegaran, Vikneswari, Heng, Hong Lee, Gan, Anna, Zang, Zhi Jiang, Wu, Yingting, Wu, Jeanie, Lee, Ming Hui, Huang, DaChuan, Ong, Pauline, Chan-on, Waraporn, Cao, Yun, Qian, Chao-Nan, Lim, Kiat Hon, Ooi, Aikseng, Dykema, Karl, Furge, Kyle, Kukongviriyapan, Veerapol, Sripa, Banchob, Wongkham, Chaisiri, Yongvanit, Puangrat, Futreal, P Andrew, Bhudhisawasdi, Vajarabhongsa, Rozen, Steve, Tan, Patrick, Teh, Bin Tean

“…Bin Tean Teh and colleagues report exome sequencing of Opisthorchis viverrini –related cholangiocarcinoma, a fatal bile duct cancer associated with liver fluke…”
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Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing by Gerlinger, Marco, Horswell, Stuart, Larkin, James, Rowan, Andrew J, Salm, Max P, Varela, Ignacio, Fisher, Rosalie, McGranahan, Nicholas, Matthews, Nicholas, Santos, Claudio R, Martinez, Pierre, Phillimore, Benjamin, Begum, Sharmin, Rabinowitz, Adam, Spencer-Dene, Bradley, Gulati, Sakshi, Bates, Paul A, Stamp, Gordon, Pickering, Lisa, Gore, Martin, Nicol, David L, Hazell, Steven, Futreal, P Andrew, Stewart, Aengus, Swanton, Charles

“…Charles Swanton and colleagues used multiregion exome sequencing to study the evolutionary histories of ten clear cell renal cell carcinomas. They observed…”
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