Search Results - "Andreux, Pénélope A."

Pharmacological approaches to restore mitochondrial function by Andreux, Pénélope A., Houtkooper, Riekelt H., Auwerx, Johan

“…Key Points Over the past decade, more evidence has accumulated regarding the involvement of mitochondrial dysfunction in the pathogenesis of type 2 diabetes,…”
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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity by Cantó, Carles, Houtkooper, Riekelt H., Pirinen, Eija, Youn, Dou Y., Oosterveer, Maaike H., Cen, Yana, Fernandez-Marcos, Pablo J., Yamamoto, Hiroyasu, Andreux, Pénélope A., Cettour-Rose, Philippe, Gademann, Karl, Rinsch, Chris, Schoonjans, Kristina, Sauve, Anthony A., Auwerx, Johan

“…As NAD+ is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function and, consequently,…”
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Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits by Andreux, Pénélope A., Williams, Evan G., Koutnikova, Hana, Houtkooper, Riekelt H., Champy, Marie-France, Henry, Hugues, Schoonjans, Kristina, Williams, Robert W., Auwerx, Johan

“…Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significantly among individuals and are difficult to model with…”
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Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis by D'Amico, Davide, Olmer, Merissa, Fouassier, Andréane M., Valdés, Pamela, Andreux, Pénélope A., Rinsch, Chris, Lotz, Martin

“…Osteoarthritis (OA) is the most common age‐related joint disorder with no effective therapy. According to the World Health Organization, OA affects over 500…”
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Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits by McKnite, Autumn M, Perez-Munoz, Maria Elisa, Lu, Lu, Williams, Evan G, Brewer, Simon, Andreux, Pénélope A, Bastiaansen, John W M, Wang, Xusheng, Kachman, Stephen D, Auwerx, Johan, Williams, Robert W, Benson, Andrew K, Peterson, Daniel A, Ciobanu, Daniel C

“…The gastrointestinal tract harbors a complex and diverse microbiota that has an important role in host metabolism. Microbial diversity is influenced by a…”
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An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement by Williams, Evan G, Mouchiroud, Laurent, Frochaux, Michael, Pandey, Ashutosh, Andreux, Pénélope A, Deplancke, Bart, Auwerx, Johan

“…The BXD genetic reference population is a recombinant inbred panel descended from crosses between the C57BL/6 (B6) and DBA/2 (D2) strains of mice, which…”
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A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans by Andreux, Pénélope A., Mouchiroud, Laurent, Wang, Xu, Jovaisaite, Virginija, Mottis, Adrienne, Bichet, Sabrina, Moullan, Norman, Houtkooper, Riekelt H., Auwerx, Johan

“…Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial…”
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Impact of the Natural Compound Urolithin A on Health, Disease, and Aging by D’Amico, Davide, Andreux, Pénélope A., Valdés, Pamela, Singh, Anurag, Rinsch, Chris, Auwerx, Johan

“…Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods…”
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Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents by Ryu, Dongryeol, Mouchiroud, Laurent, Andreux, Pénélope A, Katsyuba, Elena, Moullan, Norman, Nicolet-dit-Félix, Amandine A, Williams, Evan G, Jha, Pooja, Lo Sasso, Giuseppe, Huzard, Damien, Aebischer, Patrick, Sandi, Carmen, Rinsch, Chris, Auwerx, Johan

“…The naturally occurring compound urolithin A has been found to promote mitophagy, thereby increasing lifespan in worms and improving skeletal muscle activity…”
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The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans by Andreux, Pénélope A., Blanco-Bose, William, Ryu, Dongryeol, Burdet, Frédéric, Ibberson, Mark, Aebischer, Patrick, Auwerx, Johan, Singh, Anurag, Rinsch, Chris

“…Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical…”
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The metabolic footprint of aging in mice by Houtkooper, Riekelt H., Argmann, Carmen, Houten, Sander M., Cantó, Carles, Jeninga, Ellen H., Andreux, Pénélope A., Thomas, Charles, Doenlen, Raphaël, Schoonjans, Kristina, Auwerx, Johan

“…Aging is characterized by a general decline in cellular function, which ultimately will affect whole body homeostasis. Although DNA damage and oxidative stress…”
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Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population by Singh, Anurag, D’Amico, Davide, Andreux, Pénélope A., Dunngalvin, Gillian, Kern, Timo, Blanco-Bose, William, Auwerx, Johan, Aebischer, Patrick, Rinsch, Chris

“…Background Urolithin A (UA) is produced by gut microflora from foods rich in ellagitannins. UA has been shown to improve mitochondrial health preclinically and…”
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Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy by Denk, Dominic, Petrocelli, Valentina, Conche, Claire, Drachsler, Moritz, Ziegler, Paul K., Braun, Angela, Kress, Alena, Nicolas, Adele M., Mohs, Kathleen, Becker, Christoph, Neurath, Markus F., Farin, Henner F., Buchholz, Christian J., Andreux, Pénélope A., Rinsch, Chris, Greten, Florian R.

“…T memory stem cells (TSCM) display increased self-renewal and prolonged survival capabilities, thus preventing T cell exhaustion and promoting effective…”
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Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults by Singh, Anurag, D’Amico, Davide, Andreux, Pénélope A., Fouassier, Andréane M., Blanco-Bose, William, Evans, Mal, Aebischer, Patrick, Auwerx, Johan, Rinsch, Chris

“…Targeting mitophagy to activate the recycling of faulty mitochondria during aging is a strategy to mitigate muscle decline. We present results from a…”
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Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly by Andreux, Pénélope A., van Diemen, Marcus P. J., Heezen, Maxime R., Auwerx, Johan, Rinsch, Chris, Groeneveld, Geert Jan, Singh, Anurag

“…Aging is accompanied by a gradual decline in both muscle mass and strength over time, which can eventually lead to pathologies, such as frailty and sarcopenia…”
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Publisher Correction: Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly by Andreux, Pénélope A., van Diemen, Marcus P. J., Heezen, Maxime R., Auwerx, Johan, Rinsch, Chris, Groeneveld, Geert Jan, Singh, Anurag

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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An Evolutionarily Conserved Role for the Aryl Hydrocarbon Receptor in the Regulation of Movement: e1004673 by Williams, Evan G, Mouchiroud, Laurent, Frochaux, Michael, Pandey, Ashutosh, Andreux, Pénélope A, Deplancke, Bart, Auwerx, Johan

“…The BXD genetic reference population is a recombinant inbred panel descended from crosses between the C57BL/6 (B6) and DBA/2 (D2) strains of mice, which…”
Get full text