Search Results - "Andreu, José M"

How Protein Filaments Treadmill by Andreu, José M.

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FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics by Ruiz, Federico M, Huecas, Sonia, Santos-Aledo, Alicia, Prim, Elena A, Andreu, José M, Fernández-Tornero, Carlos

“…Treadmilling protein filaments perform essential cellular functions by growing from one end while shrinking from the other, driven by nucleotide hydrolysis…”
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Biosafety and biosecurity in Synthetic Biology: A review by Gómez-Tatay, Lucía, Hernández-Andreu, José M.

“…Synthetic Biology is a growing field which holds great promise in several areas of application. However, it also poses serious risks for human health and the…”
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Conserved GTPase mechanism in bacterial FtsZ and archaeal tubulin filaments by Andreu, José M., Ruiz, Federico M., Fernández‐Tornero, Carlos

“…Self‐assembling protein filaments are at the heart of cell function. Among them, tubulin‐like proteins are essential for cell division, DNA segregation and…”
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Bacterial cell division proteins as antibiotic targets by den Blaauwen, Tanneke, Andreu, José M., Monasterio, Octavio

“…•PBP1B crystal structure access inhibition of its GTase activity.•Inhibition of FtsZ polymerization cures mice from Staphylococcusaureus infection.•FtsW and…”
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The Antibacterial Cell Division Inhibitor PC190723 Is an FtsZ Polymer-stabilizing Agent That Induces Filament Assembly and Condensation by Andreu, José M., Schaffner-Barbero, Claudia, Huecas, Sonia, Alonso, Dulce, Lopez-Rodriguez, María L., Ruiz-Avila, Laura B., Núñez-Ramírez, Rafael, Llorca, Oscar, Martín-Galiano, Antonio J.

“…Cell division protein FtsZ can form single-stranded filaments with a cooperative behavior by self-switching assembly. Subsequent condensation and bending of…”
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Synthetic developmental regulator MciZ targets FtsZ across Bacillus species and inhibits bacterial division by Araújo‐Bazán, Lidia, Huecas, Sonia, Valle, Javier, Andreu, David, Andreu, José M.

“…Summary Cell division in most bacteria is directed by FtsZ, a conserved tubulin‐like GTPase that assembles forming the cytokinetic Z‐ring and constitutes a…”
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Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery by Huecas, Sonia, Araújo-Bazán, Lidia, Ruiz, Federico M, Ruiz-Ávila, Laura B, Martínez, R. Fernando, Escobar-Peña, Andrea, Artola, Marta, Vázquez-Villa, Henar, Martín-Fontecha, Mar, Fernández-Tornero, Carlos, López-Rodríguez, María L, Andreu, José M

“…Bacterial resistance to antibiotics makes previously manageable infections again disabling and lethal, highlighting the need for new antibacterial strategies…”
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Targeting the Assembly of Bacterial Cell Division Protein FtsZ with Small Molecules by Schaffner-Barbero, Claudia, Martín-Fontecha, Mar, Chacón, Pablo, Andreu, José M

“…FtsZ is the key protein of bacterial cell division and an emergent target for new antibiotics. It is a filament-forming GTPase and a structural homologue of…”
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Self-Organization of FtsZ Polymers in Solution Reveals Spacer Role of the Disordered C-Terminal Tail by Huecas, Sonia, Ramírez-Aportela, Erney, Vergoñós, Albert, Núñez-Ramírez, Rafael, Llorca, Oscar, Díaz, J. Fernando, Juan-Rodríguez, David, Oliva, María A., Castellen, Patricia, Andreu, José M.

“…FtsZ is a self-assembling GTPase that forms, below the inner membrane, the mid-cell Z-ring guiding bacterial division. FtsZ monomers polymerize head to tail…”
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Synthesis and Antimitotic and Tubulin Interaction Profiles of Novel Pinacol Derivatives of Podophyllotoxins by Abad, Andrés, López-Pérez, José L, del Olmo, Esther, García-Fernández, Luis F, Francesch, Andrés, Trigili, Chiara, Barasoain, Isabel, Andreu, José M, Díaz, J. Fernando, San Feliciano, Arturo

“…Several pinacol derivatives of podophyllotoxins bearing different side chains and functions at C-7 were synthesized through reductive cross-coupling of…”
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Tubulin homolog TubZ in a phage-encoded partition system by Oliva, María A, Martin-Galiano, Antonio J, Sakaguchi, Yoshihiko, Andreu, José M

“…Partition systems are responsible for the process whereby large and essential plasmids are accurately positioned to daughter cells during bacterial division…”
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The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors by Artola, Marta, Ruíz-Avila, Laura B, Ramírez-Aportela, Erney, Martínez, R Fernando, Araujo-Bazán, Lidia, Vázquez-Villa, Henar, Martín-Fontecha, Mar, Oliva, María A, Martín-Galiano, A Javier, Chacón, Pablo, López-Rodríguez, María L, Andreu, José M, Huecas, Sonia

“…FtsZ is a widely conserved tubulin-like GTPase that directs bacterial cell division and a new target for antibiotic discovery. This protein assembly machine…”
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The Search for Antibacterial Inhibitors Targeting Cell Division Protein FtsZ at Its Nucleotide and Allosteric Binding Sites by Andreu, José M, Huecas, Sonia, Araújo-Bazán, Lidia, Vázquez-Villa, Henar, Martín-Fontecha, Mar

“…The global spread of bacterial antimicrobial resistance is associated to millions of deaths from bacterial infections per year, many of which were previously…”
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Cytological Profile of Antibacterial FtsZ Inhibitors and Synthetic Peptide MciZ by Araújo-Bazán, Lidia, Ruiz-Avila, Laura B, Andreu, David, Huecas, Sonia, Andreu, José M

“…Cell division protein FtsZ is the organizer of the cytokinetic ring in almost all bacteria and a target for the discovery of new antibacterial agents that are…”
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Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites by Field, Jessica J, Pera, Benet, Gallego, Juan Estévez, Calvo, Enrique, Rodríguez-Salarichs, Javier, Sáez-Calvo, Gonzalo, Zuwerra, Didier, Jordi, Michel, Andreu, José M, Prota, Andrea E, Ménchon, Grégory, Miller, John H, Altmann, Karl-Heinz, Díaz, J. Fernando

“…The marine natural product zampanolide and analogues thereof constitute a new chemotype of taxoid site microtubule-stabilizing agents with a covalent mechanism…”
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Novel Polyphenol Oxidase Mined from a Metagenome Expression Library of Bovine Rumen: BIOCHEMICAL PROPERTIES, STRUCTURAL ANALYSIS, AND PHYLOGENETIC RELATIONSHIPS by Beloqui, Ana, Pita, Marcos, Polaina, Julio, Martínez-Arias, Arturo, Golyshina, Olga V, Zumárraga, Miren, Yakimov, Michail M, García-Arellano, Humberto, Alcalde, Miguel, Fernández, Víctor M, Elborough, Kieran, Andreu, José M, Ballesteros, Antonio, Plou, Francisco J, Timmis, Kenneth N, Ferrer, Manuel, Golyshin, Peter N

“…RL5, a gene coding for a novel polyphenol oxidase, was identified through activity screening of a metagenome expression library from bovine rumen microflora…”
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Mapping Flexibility and the Assembly Switch of Cell Division Protein FtsZ by Computational and Mutational Approaches by Martín-Galiano, Antonio J., Buey, Rubén M., Cabezas, Marta, Andreu, José M.

“…The molecular switch for nucleotide-regulated assembly and disassembly of the main prokaryotic cell division protein FtsZ is unknown despite the numerous…”
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Interactions of Bacterial Cell Division Protein FtsZ with C8-Substituted Guanine Nucleotide Inhibitors. A Combined NMR, Biochemical and Molecular Modeling Perspective by Marcelo, Filipa, Huecas, Sonia, Ruiz-Ávila, Laura B, Cañada, F. Javier, Perona, Almudena, Poveda, Ana, Martín-Santamaría, Sonsoles, Morreale, Antonio, Jiménez-Barbero, Jesús, Andreu, José M

“…FtsZ is the key protein of bacterial cell-division and target for new antibiotics. Selective inhibition of FtsZ polymerization without impairing the assembly…”
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Mitochondrial Modification Techniques and Ethical Issues by Gómez-Tatay, Lucía, Hernández-Andreu, José M, Aznar, Justo

“…Current strategies for preventing the transmission of mitochondrial disease to offspring include techniques known as mitochondrial replacement and…”
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