Search Results - "Andres Merits"

Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions by Yang, Siwy Ling, DeFalco, Louis, Anderson, Danielle E., Zhang, Yu, Aw, Jong Ghut Ashley, Lim, Su Ying, Lim, Xin Ni, Tan, Kiat Yee, Zhang, Tong, Chawla, Tanu, Su, Yan, Lezhava, Alexander, Merits, Andres, Wang, Lin-Fa, Huber, Roland G., Wan, Yue

“…SARS-CoV-2 is a major threat to global health. Here, we investigate the RNA structure and RNA-RNA interactions of wildtype (WT) and a mutant (Δ382) SARS-CoV-2…”
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Phosphorylation Sites in the Hypervariable Domain in Chikungunya Virus nsP3 Are Crucial for Viral Replication by Teppor, Mona, Žusinaite, Eva, Merits, Andres

“…Chikungunya virus (CHIKV, family ) is a mosquito-transmitted alphavirus. The positive-sense RNA genome of CHIKV encodes four nonstructural proteins (nsP1 to…”
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Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen by Burt, Felicity J, Prof, Chen, Weiqiang, PhD, Miner, Jonathan J, MD, Lenschow, Deborah J, MD, Merits, Andres, Prof, Schnettler, Esther, PhD, Kohl, Alain, PhD, Rudd, Penny A, PhD, Taylor, Adam, PhD, Herrero, Lara J, PhD, Zaid, Ali, PhD, Ng, Lisa F P, Prof, Mahalingam, Suresh, Prof

“…Summary Re-emergence of chikungunya virus, a mosquito-transmitted pathogen, is of serious public health concern. In the past 15 years, after decades of…”
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Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection by Gestuveo, Rommel J., Royle, Jamie, Donald, Claire L., Lamont, Douglas J., Hutchinson, Edward C., Merits, Andres, Kohl, Alain, Varjak, Margus

“…The escalating global prevalence of arboviral diseases emphasizes the need to improve our understanding of their biology. Research in this area has been…”
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Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection by Pingen, Marieke, Bryden, Steven R., Pondeville, Emilie, Schnettler, Esther, Kohl, Alain, Merits, Andres, Fazakerley, John K., Graham, Gerard J., McKimmie, Clive S.

“…Aedes aegypti mosquitoes are responsible for transmitting many medically important viruses such as those that cause Zika and dengue. The inoculation of viruses…”
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ICTV Virus Taxonomy Profile: Togaviridae by Chen, Rubing, Mukhopadhyay, Suchetana, Merits, Andres, Bolling, Bethany, Nasar, Farooq, Coffey, Lark L, Powers, Ann, Weaver, Scott C, Ictv Report Consortium

“…The Togaviridae is a family of small, enveloped viruses with single-stranded, positive-sense RNA genomes of 10-12 kb. Within the family, the genus Alphavirus…”
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Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays by Pohjala, Leena, Utt, Age, Varjak, Margus, Lulla, Aleksei, Merits, Andres, Ahola, Tero, Tammela, Päivi

“…Chikungunya virus (CHIKV), an alphavirus, has recently caused epidemic outbreaks and is therefore considered a re-emerging pathogen for which no effective…”
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Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein by Utt, Age, Quirin, Tania, Saul, Sirle, Hellström, Kirsi, Ahola, Tero, Merits, Andres

“…Chikungunya virus (CHIKV; genus Alphavirus, family Togaviridae) has recently caused several major outbreaks affecting millions of people. There are no licensed…”
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Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection by Oo, Adrian, Rausalu, Kai, Merits, Andres, Higgs, Stephen, Vanlandingham, Dana, Bakar, Sazaly Abu, Zandi, Keivan

“…The past decade has seen the re-emergence of Chikungunya virus (CHIKV) as a major global health threat, affecting millions around the world. Although fatal…”
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In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2 by Szemiel, Agnieszka M, Merits, Andres, Orton, Richard J, MacLean, Oscar A, Pinto, Rute Maria, Wickenhagen, Arthur, Lieber, Gauthier, Turnbull, Matthew L, Wang, Sainan, Furnon, Wilhelm, Suarez, Nicolas M, Mair, Daniel, da Silva Filipe, Ana, Willett, Brian J, Wilson, Sam J, Patel, Arvind H, Thomson, Emma C, Palmarini, Massimo, Kohl, Alain, Stewart, Meredith E

“…Remdesivir (RDV), a broadly acting nucleoside analogue, is the only FDA approved small molecule antiviral for the treatment of COVID-19 patients. To date,…”
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Chikungunya virus entry is strongly inhibited by phospholipase A2 isolated from the venom of Crotalus durissus terrificus by Santos, Igor Andrade, Shimizu, Jacqueline Farinha, de Oliveira, Débora Moraes, Martins, Daniel Oliveira Silva, Cardoso-Sousa, Léia, Cintra, Adélia Cristina Oliveira, Aquino, Victor Hugo, Sampaio, Suely Vilela, Nicolau-Junior, Nilson, Sabino-Silva, Robinson, Merits, Andres, Harris, Mark, Jardim, Ana Carolina Gomes

“…Chikungunya virus (CHIKV) is the etiologic agent of Chikungunya fever, a globally spreading mosquito-borne disease. There is no approved antiviral or vaccine…”
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Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells by Maillard, Pierre V, Van der Veen, Annemarthe G, Deddouche-Grass, Safia, Rogers, Neil C, Merits, Andres, Reis e Sousa, Caetano

“…RNA interference (RNAi) elicited by long double‐stranded (ds) or base‐paired viral RNA constitutes the major mechanism of antiviral defence in plants and…”
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The Host DHX9 DExH-Box Helicase Is Recruited to Chikungunya Virus Replication Complexes for Optimal Genomic RNA Translation by Matkovic, Roy, Bernard, Eric, Fontanel, Simon, Eldin, Patrick, Chazal, Nathalie, Hassan Hersi, Deka, Merits, Andres, Péloponèse, Jr, Jean-Marie, Briant, Laurence

“…Beyond their role in cellular RNA metabolism, DExD/H-box RNA helicases are hijacked by various RNA viruses in order to assist replication of the viral genome…”
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The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling by Varghese, Finny S, Thaa, Bastian, Amrun, Siti Naqiah, Simarmata, Diane, Rausalu, Kai, Nyman, Tuula A, Merits, Andres, McInerney, Gerald M, Ng, Lisa F P, Ahola, Tero

“…Chikungunya virus (CHIKV) has infected millions of people in the tropical and subtropical regions since its reemergence in the last decade. We recently…”
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CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome by Jungfleisch, Jennifer, Böttcher, René, Talló-Parra, Marc, Pérez-Vilaró, Gemma, Merits, Andres, Novoa, Eva Maria, Díez, Juana

“…Ample evidence indicates that codon usage bias regulates gene expression. How viruses, such as the emerging mosquito-borne Chikungunya virus (CHIKV), express…”
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The Host Nonsense-Mediated mRNA Decay Pathway Restricts Mammalian RNA Virus Replication by Balistreri, Giuseppe, Horvath, Peter, Schweingruber, Christoph, Zünd, David, McInerney, Gerald, Merits, Andres, Mühlemann, Oliver, Azzalin, Claus, Helenius, Ari

“…In addition to classically defined immune mechanisms, cell-intrinsic processes can restrict virus infection and have shaped virus evolution. The details of…”
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Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner by Cherkashchenko, Liubov, Rausalu, Kai, Basu, Sanjay, Alphey, Luke, Merits, Andres

“…Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a…”
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Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2 by Utt, Age, Das, Pratyush Kumar, Varjak, Margus, Lulla, Valeria, Lulla, Aleksei, Merits, Andres

“…Chikungunya virus (CHIKV) (genus Alphavirus) has a positive-sense RNA genome. CHIKV nonstructural protein 2 (nsP2) proteolytically processes the viral…”
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Antiviral activity of silymarin against chikungunya virus by Lani, Rafidah, Hassandarvish, Pouya, Chiam, Chun Wei, Moghaddam, Ehsan, Chu, Justin Jang Hann, Rausalu, Kai, Merits, Andres, Higgs, Stephen, Vanlandingham, Dana, Abu Bakar, Sazaly, Zandi, Keivan

“…The mosquito-borne chikungunya virus (CHIKV) causes chikungunya fever, with clinical presentations such as severe back and small joint pain and debilitating…”
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LDLR is used as a cell entry receptor by multiple alphaviruses by Zhai, Xiaofeng, Li, Xiaoling, Veit, Michael, Wang, Ningning, Wang, Yu, Merits, Andres, Jiang, Zhiwen, Qin, Yan, Zhang, Xiaoguang, Qi, Kaili, Jiao, Houqi, He, Wan-Ting, Chen, Ye, Mao, Yang, Su, Shuo

“…Alphaviruses are arboviruses transmitted by mosquitoes and are pathogenic to humans and livestock, causing a substantial public health burden. So far, several…”
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