Search Results - "Andrejko, K M"

Intraabdominal sepsis down-regulates transcription of sodium taurocholate cotransporter and multidrug resistance-associated protein in rats by Kim, P K, Chen, J, Andrejko, K M, Deutschman, C S

“…Hepatic dysfunction in sepsis is characterized by hyperbilirubinemia and intrahepatic cholestasis. We hypothesize that sepsis causes decreased hepatic…”
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Acute-phase gene expression correlates with intrahepatic tumor necrosis factor-alpha abundance but not with plasma tumor necrosis factor concentrations during sepsis/systemic inflammatory response syndrome in the rat by Andrejko, Kenneth M, Deutschman, Clifford S

“…OBJECTIVESTo test the hypothesis that after cecal ligation and puncture in the rat, there is increased expression of the tumor necrosis factor…”
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Hepatic gene expression and cytokine responses to sterile inflammation: comparison with cecal ligation and puncture sepsis in the rat by Bazel, S, Andrejko, K M, Chen, J, Deutschman, C S

“…Inflammatory stimulation of hepatic acute phase protein expression is, in part, modulated by tumor necrosis factor-alpha (TNFalpha), interleukin-1beta…”
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Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat by Andrejko, K M, Chen, J, Deutschman, C S

“…Interleukin-6 (IL-6) regulates hepatic acute phase responses by activating the transcription factor signal transducer and activator of transcription (STAT)-3…”
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Compensatory hepatic regeneration after mild, but not fulminant, intraperitoneal sepsis in rats by Weiss, Y G, Bellin, L, Kim, P K, Andrejko, K M, Haaxma, C A, Raj, N, Furth, E E, Deutschman, C S

“…Sepsis is the leading cause of death in surgical intensive care units. Although both mild sepsis secondary to cecal ligation and single puncture (CLP) and…”
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Altered hepatic gene expression in fecal peritonitis: changes in transcription of gluconeogenic, beta-oxidative, and ureagenic genes by Andrejko, K M, Deutschman, C S

“…Sepsis alters energy production and utilization by the liver. Changes in both metabolic pathways that produce substrate (gluconeogenesis or ketogenesis) for…”
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Sepsis-induced depression of rat glucose-6-phosphatase gene expression and activity by Deutschman, C S, Andrejko, K M, Haber, B A, Bellin, L, Elenko, E, Harrison, R, Taub, R

“…Sepsis in rats decreases the hepatic expression of the gluconeogenic enzyme glucose-6-phosphatase (G6Pase). The aim of this study was to investigate the…”
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Intrahepatic nuclear factor-κ B activity and α 1-acid glycoprotein transcription do not predict outcome after cecal ligation and puncture in the rat by Chen, Jodi, Raj, Nichelle, Kim, Patrick, Andrejko, Kenneth M, Deutschman, Clifford S

“…OBJECTIVESepsis is the leading cause of death in critically ill surgical patients. Septic hepatic dysfunction, an important determinant of outcome, is poorly…”
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Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat by Andrejko, K M, Chen, J, Deutschman, C S

“…Interleukin-6 (IL-6) regulates hepatic acute phase responses by activating the transcription factor signal transducer and activator of transcription (STAT)-3…”
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Transcription factors C/EBP-α and HNF-1α are associated with decreased expression of liver-specific genes in sepsis by HAAXMA, Charlotte A, KIM, Patrick K, ANDREJKO, Kenneth M, RAJ, Nichelle R, DEUTSCHMAN, Clifford S

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