Search Results - "Andrej Janež"

Glucagon-Like Peptide-1 Receptor Agonists in the Treatment of Obesity by Jensterle, Mojca, Janež, Andrej

“…Obesity treatment based on glucagon-like peptide-1 receptor agonists (GLP-1 RAs) proved to limit morbidity and mortality in adult population. In children,…”
Get more information

Once-Weekly Insulin for Type 2 Diabetes without Previous Insulin Treatment by Rosenstock, Julio, Bajaj, Harpreet S, Janež, Andrej, Silver, Robert, Begtrup, Kamilla, Hansen, Melissa V, Jia, Ting, Goldenberg, Ronald

“…In this randomized, double-blind, double-dummy, phase 2 trial, the efficacy and safety of once-weekly treatment with the basal insulin analogue icodec were…”
Get full text

Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport by Herman, Rok, Kravos, Nika Aleksandra, Jensterle, Mojca, Janež, Andrej, Dolžan, Vita

“…Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant (IR) conditions such as diabetes, prediabetes, polycystic…”
Get full text

Weight response to GLP-1 receptor agonists: Why women do it better? by Jensterle, Mojca, Rizzo, Manfredi, Janež, Andrej

“…The proportion of subjects who lost ≥5 % of baseline body weight with semaglutide was 68.8 %.7 The difference between efficacy regarding weight loss in studies…”
Get full text

Efficacy of GLP-1 RA Approved for Weight Management in Patients With or Without Diabetes: A Narrative Review by Jensterle, Mojca, Rizzo, Manfredi, Haluzík, Martin, Janež, Andrej

“…The approval of once daily liraglutide, 3.0 mg, and once weekly semaglutide, 2.4 mg, for chronic weight management provides a novel effective strategy against…”
Get full text

SGLT2 Inhibitors and the Clinical Implications of Associated Weight Loss in Type 2 Diabetes: A Narrative Review by Janež, Andrej, Fioretto, Paola

“…Introduction The obesity epidemic is closely linked to the rising prevalence of type 2 diabetes (T2D). Body weight reduction remains an important challenge in…”
Get full text

Empagliflozin on top of metformin treatment improves arterial function in patients with type 1 diabetes mellitus by Lunder, Mojca, Janić, Miodrag, Japelj, Miha, Juretič, Andrej, Janež, Andrej, Šabovič, Mišo

“…Deteriorated arterial function and high incidence of cardiovascular events characterise diabetes mellitus. Metformin and recent antidiabetic drugs, SGLT2…”
Get full text

Worldwide inertia to the use of cardiorenal protective glucose-lowering drugs (SGLT2i and GLP-1 RA) in high-risk patients with type 2 diabetes by Schernthaner, Guntram, Shehadeh, Naim, Ametov, Alexander S, Bazarova, Anna V, Ebrahimi, Fahim, Fasching, Peter, Janež, Andrej, Kempler, Péter, Konrāde, Ilze, Lalić, Nebojša M, Mankovsky, Boris, Martinka, Emil, Rahelić, Dario, Serafinceanu, Cristian, Škrha, Jan, Tankova, Tsvetalina, Visockienė, Žydrūnė

“…The disclosure of proven cardiorenal benefits with certain antidiabetic agents was supposed to herald a new era in the management of type 2 diabetes (T2D),…”
Get full text

Semaglutide in Obesity: Unmet Needs in Men by Jensterle, Mojca, Rizzo, Manfredi, Janež, Andrej

Get full text

SARS-CoV-2 Omicron symptoms and adverse effects of GLP-1 RA therapy by Jensterle, Mojca, Battelino, Tadej, Janež, Andrej

Get full text

Efficacy, safety, and patient satisfaction with oral semaglutide: first single-centre clinical experience by Janić, Miodrag, Jovanović, Marija, Janež, Andrej, Lunder, Mojca

“…Objective To explore the effects of oral semaglutide on glycaemic parameters, body weight, and satisfaction in the first recipient patients with type 2…”
Get full text

Semaglutide reduces fat accumulation in the tongue: A randomized single-blind, pilot study by Jensterle, Mojca, Ferjan, Simona, Vovk, Andrej, Battelino, Tadej, Rizzo, Manfredi, Janež, Andrej

“…•Fat accumulation in the tongue may represent an earlier marker of body fat depot.•Lingual fat accounts for collapsibility of the tongue and leads to sleep…”
Get full text

Comparison of plasma metanephrines in patients with cyanotic and acyanotic congenital heart disease by Jensterle, Mojca, Podbregar, Ana, Janež, Andrej, Rakusa, Matej, Goricar, Katja, Prokšelj, Katja

“…Purpose The co-occurrence of cyanotic congenital heart disease (CCHD) and PHEO/PGL has been reported, but the role of the hypoxic environment in the…”
Get full text

Therapeutic Potential of Glucagon-like Peptide-1 Agonists in Polycystic Ovary Syndrome: From Current Clinical Evidence to Future Perspectives by Jensterle, Mojca, Herman, Rok, Janež, Andrej

“…Despite the continuous effort to understand the pathophysiology and determine potential therapeutic targets, PCOS treatment largely depends on lifestyle…”
Get full text

Physiologically Achievable Concentration of 2-Deoxy-D-Glucose Stimulates IFN-γ Secretion in Activated T Cells In Vitro by Repas, Jernej, Frlic, Tjaša, Snedec, Tadeja, Kopitar, Andreja Nataša, Sourij, Harald, Janež, Andrej, Pavlin, Mojca

“…2-deoxy-D-glucose (2DG) is a glycolysis and protein N-glycosylation inhibitor with promising anti-tumor and immunomodulatory effects. However, 2DG can also…”
Get full text

The Current and Emerging Role of Statins in the Treatment of PCOS: The Evidence to Date by Kolnikaj, Tea Shehu, Herman, Rok, Janež, Andrej, Jensterle, Mojca

“…Polycystic ovary syndrome (PCOS) manifests a multifactorial pathology characterized by polycystic ovaries, menstrual cycle disorders, varying degrees of…”
Get full text

Molecular mechanisms of insulin resistance and associated diseases by Mlinar, Barbara, Marc, Janja, Janež, Andrej, Pfeifer, Marija

“…Insulin resistance is a state in which higher than normal concentrations of insulin are required for normal response. The most common underlying cause is…”
Get full text

Health-Related Quality of Life Assessment in Older Patients with Type 1 and Type 2 Diabetes by Volčanšek, Špela, Lunder, Mojca, Janež, Andrej

“…Type 1 (T1D) and type 2 diabetes (T2D) are determinants of health-related outcomes including health-related quality of life (HRQOL). We aimed to determine…”
Get full text

CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients by Klen, Jasna, Dolžan, Vita, Janež, Andrej

“…Purpose Sulphonylureas (SU) are widely used in the management of type 2 diabetes. We investigated the influence of CYP2C9 , KCNJ11 and ABCC8 polymorphisms on…”
Get full text

Insulin Therapy in Adults with Type 1 Diabetes Mellitus: a Narrative Review by Janež, Andrej, Guja, Cristian, Mitrakou, Asimina, Lalic, Nebojsa, Tankova, Tsvetalina, Czupryniak, Leszek, Tabák, Adam G., Prazny, Martin, Martinka, Emil, Smircic-Duvnjak, Lea

“…Here, we review insulin management options and strategies in nonpregnant adult patients with type 1 diabetes mellitus (T1DM). Most patients with T1DM should…”
Get full text