Search Results - "Andreassen, A"

Psychiatric genetics and the structure of psychopathology by Smoller, Jordan W., Andreassen, Ole A., Edenberg, Howard J., Faraone, Stephen V., Glatt, Stephen J., Kendler, Kenneth S.

“…For over a century, psychiatric disorders have been defined by expert opinion and clinical observation. The modern DSM has relied on a consensus of experts to…”
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The polygenic architecture of schizophrenia — rethinking pathogenesis and nosology by Smeland, Olav B., Frei, Oleksandr, Dale, Anders M., Andreassen, Ole A.

“…Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality. Although the past two decades have seen limited improvement in the…”
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Shared genetic loci between depression and cardiometabolic traits by Torgersen, Kristin, Rahman, Zillur, Bahrami, Shahram, Hindley, Guy Frederick Lanyon, Parker, Nadine, Frei, Oleksandr, Shadrin, Alexey, O'Connell, Kevin S, Tesli, Martin, Smeland, Olav B, Munkhaugen, John, Djurovic, Srdjan, Dammen, Toril, Andreassen, Ole A

“…Epidemiological and clinical studies have found associations between depression and cardiovascular disease risk factors, and coronary artery disease patients…”
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The role of norepinephrine in the pathophysiology of schizophrenia by Mäki-Marttunen, Verónica, Andreassen, Ole A., Espeseth, Thomas

“…•LC-NE system is involved in motivation and cognition in humans.•This system participates in mechanisms of stress response.•LC-NE system may be connected to…”
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White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction by Beck, Dani, de Lange, Ann-Marie G., Maximov, Ivan I., Richard, Geneviève, Andreassen, Ole A., Nordvik, Jan E., Westlye, Lars T.

“…The macro- and microstructural architecture of human brain white matter undergoes substantial alterations throughout development and ageing. Most of our…”
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The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis by Valstad, Mathias, Alvares, Gail A., Egknud, Maiken, Matziorinis, Anna Maria, Andreassen, Ole A., Westlye, Lars T., Quintana, Daniel S.

“…•There was a positive association between central and peripheral oxytocin concentrations.•This association was moderated by experimental context.•No…”
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Increased mortality in schizophrenia due to cardiovascular disease - a non-systematic review of epidemiology, possible causes, and interventions by Ringen, Petter Andreas, Engh, John A, Birkenaes, Astrid B, Dieset, Ingrid, Andreassen, Ole A

“…Schizophrenia is among the major causes of disability worldwide and the mortality from cardiovascular disease (CVD) is significantly elevated. There is a…”
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Oxytocin pathway gene networks in the human brain by Quintana, Daniel S., Rokicki, Jaroslav, van der Meer, Dennis, Alnæs, Dag, Kaufmann, Tobias, Córdova-Palomera, Aldo, Dieset, Ingrid, Andreassen, Ole A., Westlye, Lars T.

“…Oxytocin is a neuropeptide involved in animal and human reproductive and social behavior. Three oxytocin signaling genes have been frequently implicated in…”
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Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation by Frei, Oleksandr, Holland, Dominic, Smeland, Olav B., Shadrin, Alexey A., Fan, Chun Chieh, Maeland, Steffen, O’Connell, Kevin S., Wang, Yunpeng, Djurovic, Srdjan, Thompson, Wesley K., Andreassen, Ole A., Dale, Anders M.

“…Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders,…”
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The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery by Dahl, Johan, Ormstad, Heidi, Aass, Hans Christian D, Malt, Ulrik Fredrik, Bendz, Lil Träskman, Sandvik, Leiv, Brundin, Lena, Andreassen, Ole A

“…Abstract Background Cytokines are implicated in the pathophysiology of major depressive disorder (MDD). However, the pattern of alterations in cytokine levels…”
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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline by Jonsson, Thorlakur, Atwal, Jasvinder K., Steinberg, Stacy, Snaedal, Jon, Jonsson, Palmi V., Bjornsson, Sigurbjorn, Stefansson, Hreinn, Sulem, Patrick, Gudbjartsson, Daniel, Maloney, Janice, Hoyte, Kwame, Gustafson, Amy, Liu, Yichin, Lu, Yanmei, Bhangale, Tushar, Graham, Robert R., Huttenlocher, Johanna, Bjornsdottir, Gyda, Andreassen, Ole A., Jönsson, Erik G., Palotie, Aarno, Behrens, Timothy W., Magnusson, Olafur T., Kong, Augustine, Thorsteinsdottir, Unnur, Watts, Ryan J., Stefansson, Kari

“…A coding mutation in APP , the gene that encodes the amyloid-β precursor protein, is found to protect against Alzheimer’s disease and cognitive decline in the…”
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Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls by Moberget, T, Doan, N T, Alnæs, D, Kaufmann, T, Córdova-Palomera, A, Lagerberg, T V, Diedrichsen, J, Schwarz, E, Zink, M, Eisenacher, S, Kirsch, P, Jönsson, E G, Fatouros-Bergman, H, Flyckt, L, Pergola, G, Quarto, T, Bertolino, A, Barch, D, Meyer-Lindenberg, A, Agartz, I, Andreassen, O A, Westlye, L T

“…Although cerebellar involvement across a wide range of cognitive and neuropsychiatric phenotypes is increasingly being recognized, previous large-scale studies…”
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Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model by Holland, Dominic, Frei, Oleksandr, Desikan, Rahul, Fan, Chun-Chieh, Shadrin, Alexey A, Smeland, Olav B, Sundar, V S, Thompson, Paul, Andreassen, Ole A, Dale, Anders M

“…Estimating the polygenicity (proportion of causally associated single nucleotide polymorphisms (SNPs)) and discoverability (effect size variance) of causal…”
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Population-based neuroimaging reveals traces of childbirth in the maternal brain by de Lange, Ann-Marie G., Kaufmann, Tobias, van der Meer, Dennis, Maglanoc, Luigi A., Alnæs, Dag, Moberget, Torgeir, Douaud, Gwenaëlle, Andreassen, Ole A., Westlye, Lars T.

“…Maternal brain adaptations have been found across pregnancy and postpartum, but little is known about the long-term effects of parity on the maternal brain…”
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Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays by Thunemann, Martin, Lu, Yichen, Liu, Xin, Kılıç, Kıvılcım, Desjardins, Michèle, Vandenberghe, Matthieu, Sadegh, Sanaz, Saisan, Payam A., Cheng, Qun, Weldy, Kimberly L., Lyu, Hongming, Djurovic, Srdjan, Andreassen, Ole A., Dale, Anders M., Devor, Anna, Kuzum, Duygu

“…Recent advances in optical technologies such as multi-photon microscopy and optogenetics have revolutionized our ability to record and manipulate neuronal…”
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Somatic Comorbidity in Schizophrenia: Some Possible Biological Mechanisms Across the Life Span by Dieset, Ingrid, Andreassen, Ole A, Haukvik, Unn K

“…Schizophrenia is associated with decreased life expectancy (15-25 y) compared to the general population, with comorbid somatic diseases and in particular…”
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Understanding the genetic determinants of the brain with MOSTest by van der Meer, Dennis, Frei, Oleksandr, Kaufmann, Tobias, Shadrin, Alexey A., Devor, Anna, Smeland, Olav B., Thompson, Wesley K., Fan, Chun Chieh, Holland, Dominic, Westlye, Lars T., Andreassen, Ole A., Dale, Anders M.

“…Regional brain morphology has a complex genetic architecture, consisting of many common polymorphisms with small individual effects. This has proven…”
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Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia by Ruderfer, D M, Fanous, A H, Ripke, S, McQuillin, A, Amdur, R L, Gejman, P V, O'Donovan, M C, Andreassen, O A, Djurovic, S, Hultman, C M, Kelsoe, J R, Jamain, S, Landén, M, Leboyer, M, Nimgaonkar, V, Nurnberger, J, Smoller, J W, Craddock, N, Corvin, A, Sullivan, P F, Holmans, P, Sklar, P, Kendler, K S

“…Bipolar disorder and schizophrenia are two often severe disorders with high heritabilities. Recent studies have demonstrated a large overlap of genetic risk…”
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Deep neural networks learn general and clinically relevant representations of the ageing brain by Leonardsen, Esten H., Peng, Han, Kaufmann, Tobias, Agartz, Ingrid, Andreassen, Ole A., Celius, Elisabeth Gulowsen, Espeseth, Thomas, Harbo, Hanne F., Høgestøl, Einar A., Lange, Ann-Marie de, Marquand, Andre F., Vidal-Piñeiro, Didac, Roe, James M., Selbæk, Geir, Sørensen, Øystein, Smith, Stephen M., Westlye, Lars T., Wolfers, Thomas, Wang, Yunpeng

“…•Brain age CNNs achieve state-of-the-art performance in a large, multisite dataset.•A regression-based architecture outperform others in generalizing to new…”
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In Vivo Hippocampal Subfield Volumes in Schizophrenia and Bipolar Disorder by Haukvik, Unn K, Westlye, Lars T, Mørch-Johnsen, Lynn, Jørgensen, Kjetil N, Lange, Elisabeth H, Dale, Anders M, Melle, Ingrid, Andreassen, Ole A, Agartz, Ingrid

“…Abstract Background Hippocampal dysfunction and volume reductions have been reported in patients with schizophrenia and bipolar disorder. The hippocampus…”
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