The total pregnancy potential per oocyte aspiration after assisted reproduction—in how many cycles are biologically competent oocytes available?

The total pregnancy potential per oocyte aspiration after assisted reproduction—in how many cycles are biologically competent oocytes available?

Purpose While stimulation of women prior to assisted reproduction is associated with increased success rates, the total biological pregnancy potential per stimulation cycle is rarely assessed. Methods Retrospective sequential cohort study of the cumulative live birth rate in 1148 first IVF/ICSI-cycl...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics Vol. 33; no. 7; pp. 849 - 854
Main Authors: Lemmen, J. G., Rodríguez, N. M., Andreasen, L. D., Loft, A., Ziebe, S.
Format: Journal Article
Language:English
Published: New York Springer US 01-07-2016
Springer Nature B.V
Subjects:
Adult
Assisted Reproduction Technologies
Birth Rate
Children & youth
Chorionic Gonadotropin - blood
Cryopreservation
Embryo Transfer - methods
Embryos
Female
Fertility
Fertilization in Vitro - methods
Gynecology
Human Genetics
Humans
In vitro fertilization
Medicine
Medicine & Public Health
Oocyte Retrieval - methods
Oocytes - cytology
Oocytes - physiology
Pregnancy
Pregnancy Rate
Reproductive Medicine
Retrospective Studies
Treatment Outcome
Young Adult
Denmark
In vitro fertilization
Competence
Utilization
Live birth
Assisted reproduction
Oocytes
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Summary:Purpose While stimulation of women prior to assisted reproduction is associated with increased success rates, the total biological pregnancy potential per stimulation cycle is rarely assessed. Methods Retrospective sequential cohort study of the cumulative live birth rate in 1148 first IVF/ICSI-cycles and 5-year follow up of frozen embryo replacement (FER) cycles were used. Oocyte number, number of embryos transferred, and cryopreserved/thawed and transferred embryos in a FER cycle were registered for all patients. Children per oocyte and per transferred embryo and percentage of cycles with births were calculated. Results We obtained 9529 oocytes. Embryos (2507) were transferred in either fresh or FER cycles, resulting in 422 births and 474 live born children. Median age of the women was 32.5 years (range 20–41.5 years). In total, 34.3 % of all cycles ended with a live birth while in 65.7 % of the cycles, no oocytes were capable of developing into a child. The average number of oocytes needed per live born child after transfer of fresh and thawed embryos was 20 as only 5.0 % of oocytes aspirated in the first IVF/ICSI cycle had the competence to develop into a child. Conclusions In our setting, overall 5.0 % of the oocytes in a first cycle were biologically competent and in around 2/3 of all cycles, none of the oocytes had the potential to result in the birth of a child.
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ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-016-0707-3