Search Results - "Andreas Natsch"

The Nrf2-Keap1-ARE Toxicity Pathway as a Cellular Sensor for Skin Sensitizers—Functional Relevance and a Hypothesis on Innate Reactions to Skin Sensitizers by Natsch, Andreas

“…With the tight deadlines set both by the public and by the regulatory authorities to replace animal tests for toxicological endpoints relevant to the…”
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Scientific discrepancies in European regulatory proposals on endocrine disruptors—REACH regulation quo vadis? by Natsch, Andreas

“…The EU chemical strategy for sustainability places a high focus on endocrine-disrupting chemicals (ED), the importance of their identification with increased…”
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Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro by Emter, Roger, Ellis, Graham, Natsch, Andreas

“…In vitro tests are needed to replace animal tests to screen for the skin sensitization potential of chemicals. Skin sensitizers are electrophilic molecules and…”
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LC-MS–Based Characterization of the Peptide Reactivity of Chemicals to Improve the In Vitro Prediction of the Skin Sensitization Potential by Natsch, Andreas, Gfeller, Hans

“…A key step in the skin sensitization process is the formation of a covalent adduct between skin sensitizers and endogenous proteins and/or peptides in the…”
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What Makes Us Smell: The Biochemistry of Body Odour and the Design of New Deodorant Ingredients by Natsch, Andreas

“…Today, axilla odours are socially stigmatized and are targeted with deodorants and antiperspirants representing a multi-billion market. Axilla odours aren't…”
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Utility of rat liver S9 fractions to study skin-sensitizing prohaptens in a modified KeratinoSens assay by Natsch, Andreas, Haupt, Tina

“…Prohaptens are chemicals, which may cause skin sensitization after being converted into electrophilic molecules by skin enzymes. Aroclor-induced rat liver S9…”
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Predicting skin sensitizer potency based on in vitro data from KeratinoSens and kinetic peptide binding: global versus domain-based assessment by Natsch, Andreas, Emter, Roger, Gfeller, Hans, Haupt, Tina, Ellis, Graham

“…Three in vitro methods for the prediction of the skin sensitization hazard have been validated. However, predicting sensitizer potency is a key requirement for…”
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A dataset on 145 chemicals tested in alternative assays for skin sensitization undergoing prevalidation by Natsch, Andreas, Ryan, Cindy A., Foertsch, Leslie, Emter, Roger, Jaworska, Joanna, Gerberick, Frank, Kern, Petra

“…ABSTRACT Skin sensitization is a key endpoint for cosmetic ingredients, with a forthcoming ban for animal testing in Europe. Four alternative tests have so far…”
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Nrf2 Activation as a Key Event Triggered by Skin Sensitisers: The Development of the Stable KeratinoSens Reporter Gene Assay by Natsch, Andreas, Emter, Roger

“…The 21st century paradigm for toxicology and the adverse outcome pathway concept envisage a future toxicology largely based on mechanistic in vitro assays and…”
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Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy by Jaworska, Joanna S., Natsch, Andreas, Ryan, Cindy, Strickland, Judy, Ashikaga, Takao, Miyazawa, Masaaki

“…The presented Bayesian network Integrated Testing Strategy (ITS-3) for skin sensitization potency assessment is a decision support system for a risk assessor…”
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Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice by Jaworska, Joanna, Dancik, Yuri, Kern, Petra, Gerberick, Frank, Natsch, Andreas

“…ABSTRACT Frameworks to predict in vivo effects by integration of in vitro, in silico and in chemico information using mechanistic insight are needed to meet…”
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Examining Uncertainty in In Vitro–In Vivo Extrapolation Applied in Fish Bioconcentration Models by Laue, Heike, Hostettler, Lu, Badertscher, Remo P, Jenner, Karen J, Sanders, Gordon, Arnot, Jon A, Natsch, Andreas

“…In vitro biotransformation rates were determined for 30 chemicals, mostly fragrance ingredients, using trout liver S9 fractions (RT-S9) and incorporated into…”
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Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2: Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line by Emter, Roger, Natsch, Andreas

“…Heme oxygenase (decycling) 1 (HMOX1) is the most consistently found genetic marker induced by skin sensitizers. HMOX1 is often referred to as typical gene…”
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Body odour of monozygotic human twins: a common pattern of odorant carboxylic acids released by a bacterial aminoacylase from axilla secretions contributing to an inherited body odour type by Kuhn, Fabian, Natsch, Andreas

“…It is currently not fully established whether human individuals have a genetically determined, individual-specific body odour. Volatile carboxylic acids are a…”
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Chemical Reactivity and Skin Sensitization Potential for Benzaldehydes: Can Schiff Base Formation Explain Everything? by Natsch, Andreas, Gfeller, Hans, Haupt, Tina, Brunner, Gerhard

“…Skin sensitizers chemically modify skin proteins rendering them immunogenic. Sensitizing chemicals have been divided into applicability domains according to…”
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Systematic evaluation of non-animal test methods for skin sensitisation safety assessment by Reisinger, Kerstin, Hoffmann, Sebastian, Alépée, Nathalie, Ashikaga, Takao, Barroso, Joao, Elcombe, Cliff, Gellatly, Nicola, Galbiati, Valentina, Gibbs, Susan, Groux, Hervé, Hibatallah, Jalila, Keller, Donald, Kern, Petra, Klaric, Martina, Kolle, Susanne, Kuehnl, Jochen, Lambrechts, Nathalie, Lindstedt, Malin, Millet, Marion, Martinozzi-Teissier, Silvia, Natsch, Andreas, Petersohn, Dirk, Pike, Ian, Sakaguchi, Hitoshi, Schepky, Andreas, Tailhardat, Magalie, Templier, Marie, van Vliet, Erwin, Maxwell, Gavin

“…•Non-animal data for skin sensitisation risk assessment are urgently needed.•This has led to the development of a number of in vitro test methods.•Cosmetics…”
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A critical assessment of the estrogenic potency of benzyl salicylate by Natsch, Andreas, Hostettler, Lu, Haupt, Tina, Laue, Heike

“…•Benzyl salicylate (BS) is on priority lists for evaluation of estrogenic effects.•New data in both MCF7 (E-screen) and luciferase transactivation…”
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Benzoyl-CoA conjugate accumulation as an initiating event for male reprotoxic effects in the rat? Structure–activity analysis, species specificity, and in vivo relevance by Laue, Heike, Badertscher, Remo P., Hostettler, Lu, Weiner-Sekiya, Yumiko, Haupt, Tina, Nordone, Adrian, Adamson, Gregory M., Natsch, Andreas

“…A number of para -substituted benzoic acids ( p -BA) and chemicals metabolized to p -BA have been found to confer adverse effects in male rats on sperm…”
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Nature-derived epoxy resins: Synthesis, allergenicity, and thermosetting properties of pinoresinol diglycidyl ether by O’Boyle, Niamh M, Niklasson, Ida B, Ponting, David J, Ortega, Miguel A, Seifert, Tina, Natsch, Andreas, Luthman, Kristina, Karlberg, Ann-Therese

“…We describe a novel nature-derived epoxy resin monomer (ERM) derived from the plant lignan pinoresinol. Epoxy resins are thermosetting materials in global…”
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Gene expression changes induced by skin sensitizers in the KeratinoSens™ cell line: Discriminating Nrf2-dependent and Nrf2-independent events by Emter, Roger, van der Veen, Jochem W., Adamson, Greg, Ezendam, Janine, van Loveren, Henk, Natsch, Andreas

“…•The sensitizer-induced gene expression was studied in presence of Nrf2-siRNA.•The sensitizer-induced luciferase in KeratinoSensTM cells is dependent on…”
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