Search Results - "Andreas Klos"

International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors by Klos, Andreas, Wende, Elisabeth, Wareham, Kathryn J, Monk, Peter N

“…The activation of the complement cascade, a cornerstone of the innate immune response, produces a number of small (74-77 amino acid) fragments, originally…”
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The role of the anaphylatoxins in health and disease by Klos, Andreas, Tenner, Andrea J., Johswich, Kay-Ole, Ager, Rahasson R., Reis, Edimara S., Köhl, Jörg

“…The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in…”
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Interaction between the coagulation and complement system by Amara, Umme, Rittirsch, Daniel, Flierl, Michael, Bruckner, Uwe, Klos, Andreas, Gebhard, Florian, Lambris, John D, Huber-Lang, Markus

“…The complement system as a main column of innate immunity and the coagulation system as a main column in hemostasis undergo massive activation early after…”
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Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor by Glatzer, Franziska, PhD, Gschwandtner, Maria, PhD, Ehling, Sarah, DVM, Rossbach, Kristine, DVM, Janik, Katrin, PhD, Klos, Andreas, MD, Bäumer, Wolfgang, DVM, Kietzmann, Manfred, DVM, Werfel, Thomas, MD, Gutzmer, Ralf, MD

“…Background Epidermal hyperproliferation resulting in acanthosis is an important clinical observation in patients with atopic dermatitis, and its underlying…”
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Complement and Chlamydia psittaci : Non-Myeloid-Derived C3 Predominantly Induces Protective Adaptive Immune Responses in Mouse Lung Infection by Kohn, Martin, Lanfermann, Christian, Laudeley, Robert, Glage, Silke, Rheinheimer, Claudia, Klos, Andreas

“…Recent advances in complement research have revolutionized our understanding of its role in immune responses. The immunomodulatory features of complement in…”
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Complement and Chlamydia psittaci : Early Complement-Dependent Events Are Important for DC Migration and Protection During Mouse Lung Infection by Kohn, Martin, Lanfermann, Christian, Laudeley, Robert, Glage, Silke, Rheinheimer, Claudia, Klos, Andreas

“…The zoonotic intracellular bacterium causes life-threatening pneumonia in humans. During mouse lung infection, complement factor C3 and the anaphylatoxin C3a…”
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Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme by Zemtsovski, Jan D, Tumpara, Srinu, Schmidt, Sonja, Vijayan, Vijith, Klos, Andreas, Laudeley, Robert, Held, Julia, Immenschuh, Stephan, Wurm, Florian M, Welte, Tobias, Haller, Hermann, Janciauskiene, Sabina, Shushakova, Nelli

“…Excessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology of multi-organ dysfunction syndrome (MODS) in…”
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Phosphorylation of C3a receptor at multiple sites mediates desensitization, β-arrestin-2 recruitment and inhibition of NF-κB activity in mast cells by Gupta, Kshitij, Subramanian, Hariharan, Klos, Andreas, Ali, Hydar

“…Phosphorylation of G protein coupled receptors (GPCRs) by G protein coupled receptor kinases (GRKs) and the subsequent recruitment of β-arrestins are important…”
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Silent neonatal influenza A virus infection primes systemic antimicrobial immunity by Heinemann, Anna Sophie, Stalp, Jan Lennart, Bonifacio, João Pedro Pereira, Silva, Filo, Willers, Maike, Heckmann, Julia, Fehlhaber, Beate, Völlger, Lena, Raafat, Dina, Normann, Nicole, Klos, Andreas, Hansen, Gesine, Schmolke, Mirco, Viemann, Dorothee

“…Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majority of these infections remain asymptomatic, especially among…”
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Chlamydia trachomatis Cross-Serovar Protection during Experimental Lung Reinfection in Mice by Lanfermann, Christian, Kohn, Martin, Laudeley, Robert, Rheinheimer, Claudia, Klos, Andreas

“…Chlamydia trachomatis causes most bacterial sexually transmitted diseases worldwide. Different major outer membrane proteins (MOMPs) define various serovars of…”
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Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections by Muenstermann, Marcel, Strobel, Lea, Klos, Andreas, Wetsel, Rick A., Woodruff, Trent M., Köhl, Jörg, Johswich, Kay O.

“…The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane…”
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A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci by Bode, Jenny, Dutow, Pavel, Sommer, Kirsten, Janik, Katrin, Glage, Silke, Tümmler, Burkhard, Munder, Antje, Laudeley, Robert, Sachse, Konrad W, Klos, Andreas

“…The complement system modulates the intensity of innate and specific immunity. While it protects against infections by extracellular bacteria its role in…”
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The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice by Wende, Elisabeth, Laudeley, Robert, Bleich, André, Bleich, Eva, Wetsel, Rick A, Glage, Silke, Klos, Andreas

“…Inflammatory bowel diseases are a critical public health issue, and as treatment options remain limited, there is a need to unravel the underlying…”
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Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac by Thalmann, Jessica, Janik, Katrin, May, Martin, Sommer, Kirsten, Ebeling, Jenny, Hofmann, Fred, Genth, Harald, Klos, Andreas

“…The intracellular bacterium Chlamydia trachomatis causes infections of urogenital tract, eyes or lungs. Alignment reveals homology of CT166, a putative…”
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DXD motif-dependent and -independent effects of the chlamydia trachomatis cytotoxin CT166 by Bothe, Miriam, Dutow, Pavel, Pich, Andreas, Genth, Harald, Klos, Andreas

“…The Gram-negative, intracellular bacterium Chlamydia trachomatis causes acute and chronic urogenital tract infection, potentially leading to infertility and…”
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Chlamydia inhibit host cell apoptosis by degradation of proapoptotic BH3-only proteins by Fischer, Silke F, Vier, Juliane, Kirschnek, Susanne, Klos, Andreas, Hess, Simone, Ying, Songmin, Häcker, Georg

“…Chlamydia are obligate intracellular bacteria that replicate in a vacuole inside a host cell. Chlamydial infection has been shown to protect the host cell…”
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Prophylactic Multi-Subunit Vaccine against Chlamydia trachomatis: In Vivo Evaluation in Mice by Lanfermann, Christian, Wintgens, Sebastian, Ebensen, Thomas, Kohn, Martin, Laudeley, Robert, Schulze, Kai, Rheinheimer, Claudia, Hegemann, Johannes H., Guzmán, Carlos Alberto, Klos, Andreas

“…Chlamydia trachomatis is the most frequent sexually-transmitted disease-causing bacterium. Urogenital serovars of this intracellular pathogen lead to…”
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Ligand Specificity of the Anaphylatoxin C5L2 Receptor and Its Regulation on Myeloid and Epithelial Cell Lines by Johswich, Kay, Martin, Myriam, Thalmann, Jessica, Rheinheimer, Claudia, Monk, Peter N., Klos, Andreas

“…During complement activation the pro-inflammatory anaphylatoxins C3a and C5a are generated, which interact with the C3a receptor and C5a receptor (CD88),…”
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Severity of Allergic Airway Disease Due to House Dust Mite Allergen Is Not Increased after Clinical Recovery of Lung Infection with Chlamydia pneumoniae in Mice by Dutow, Pavel, Lingner, Sandra, Laudeley, Robert, Glage, Silke, Hoymann, Heinz-Gerd, Dittrich, Anna-Maria, Fehlhaber, Beate, Müller, Meike, Braun, Armin, Klos, Andreas

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate‐induced models of inflammatory bowel disease by Johswich, Kay, Martin, Myriam, Bleich, André, Kracht, Michael, Dittrich‐Breiholz, Oliver, Gessner, J. Engelbert, Suerbaum, Sebastian, Wende, Elisabeth, Rheinheimer, Claudia, Klos, Andreas

“…Background: Inflammatory bowel disease (IBD) is a critical public health issue; more and more people are affected, but treatment options remain limited…”
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