Search Results - "Andreana, Peter R."

Developments in Carbohydrate-Based Cancer Therapeutics by Hossain, Farzana, Andreana, Peter R

“…Cancer cells of diverse origins express extracellular tumor-specific carbohydrate antigens (TACAs) because of aberrant glycosylation. Overexpressed TACAs on…”
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A Bioinspired Ugi/Michael/Aza-Michael Cascade Reaction in Aqueous Media: Natural-Product-like Molecular Diversity by Santra, Soumava, Andreana, Peter R.

“…Whole in one! A one‐pot microwave‐assisted reaction sequence that consists of an Ugi/Michael/aza‐Michael transformation gives access to quaternary spirocenters…”
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Guidelines for O‑Glycoside Formation from First Principles by Andreana, Peter R, Crich, David

“…The complexity and irreproducibility of glycosylation reactions retard progress in the glycosciences. Application of the steady-state hypothesis to transient…”
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Glycomimetics and Glycoconjugates in Drug Discovery by Xavier, Nuno M, Andreana, Peter R

“…This Special Issue of presents one review and six original articles that are demonstrative of the importance of glycomimetics and glycoconjugates as privileged…”
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Sialyl-Tn Polysaccharide A1 as an Entirely Carbohydrate Immunogen: Synthesis and Immunological Evaluation by Shi, Mengchao, Kleski, Kristopher A, Trabbic, Kevin R, Bourgault, Jean-Paul, Andreana, Peter R

“…Sialyl Thomsen-nouveau (STn) is a tumor-associated carbohydrate antigen (TACA) that is overexpressed in a variety of carcinomas such as breast, ovarian, and…”
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Entirely Carbohydrate-Based Vaccines: An Emerging Field for Specific and Selective Immune Responses by Nishat, Sharmeen, Andreana, Peter R

“…Carbohydrates are regarded as promising targets for vaccine development against infectious disease because cell surface glycans on many infectious agents are…”
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Enhanced Immune Response Against the Thomsen-Friedenreich Tumor Antigen Using a Bivalent Entirely Carbohydrate Conjugate by Kleski, Kristopher A, Trabbic, Kevin R, Shi, Mengchao, Bourgault, Jean-Paul, Andreana, Peter R

“…The Thomsen-Friedenreich (TF) antigen is a key target for the development of anticancer vaccines, and this ongoing challenge remains relevant due to the poor…”
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Immunological Response from an Entirely Carbohydrate Antigen: Design of Synthetic Vaccines Based on Tn−PS A1 Conjugates by De Silva, Ravindra A, Wang, Qianli, Chidley, Tristan, Appulage, Dananjaya K, Andreana, Peter R

“…An entirely carbohydrate-based immunogen consisting of a zwitterionic polysaccharide (ZPS) PS A1 and the well-known tumor antigen Tn has been designed,…”
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Methyl isocyanide as a convertible functional group for the synthesis of spirocyclic oxindole γ-lactams via post-Ugi-4CR/transamidation/cyclization in a one-pot, three-step sequence by Maddirala, Amarendar Reddy, Andreana, Peter R

“…The synthesis of spiro[indoline-3,2'-pyrrole]-2,5'(1' )-diones and spiro[indoline-3,2'-pyrrolidine]-2,5'-diones, via a post-Ugi-domino…”
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A one-pot multicomponent coupling/cyclization for natural product herbicide (±)-thaxtomin A by Bourgault, Jean Paul, Maddirala, Amarendar Reddy, Andreana, Peter R

“…Herbicide (±)-thaxtomin A has been synthesized in a one-pot process with a 32% isolated yield. A multicomponent coupling reaction was utilized to prepare in…”
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Stereochemical Control of the Passerini Reaction by Andreana, Peter R, Liu, Chang C, Schreiber, Stuart L

“…A catalytic asymmetric Passerini reaction using tridentate indan (pybox) Cu(II) Lewis acid complex 4 with substrates capable of bidentate coordination has been…”
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Editorial: Carbohydrate-Based Molecules in Medicinal Chemistry by Xavier, Nuno M, Andreana, Peter R, Carvalho, Ivone, von Itzstein, Mark

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Total Synthesis of Zwitterionic Tetrasaccharide Repeating Unit from Bacteroides fragilis ATCC 25285/NCTC 9343 Capsular Polysaccharide PS A1 with Alternating Charges on Adjacent Monosaccharides by Eradi, Pradheep, Ghosh, Samir, Andreana, Peter R

“…The tetrasaccharide repeating unit of zwitterionic polysaccharide A1 (PS A1) from Bacteroides fragilis ATCC 25285/NCTC 9343 has been synthesized using a linear…”
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Synthesis of an Aminooxy Derivative of the Tetrasaccharide Repeating Unit of Streptococcus dysgalactiae 2023 Polysaccharide for a PS A1 Conjugate Vaccine by Ghosh, Samir, Nishat, Sharmeen, Andreana, Peter R

“…A highly efficient and stereocontrolled synthesis of an aminooxy derivative of the tetrasaccharide repeating unit of a rhamnose-rich polysaccharide isolated…”
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Synthesis of substrate analogues as potential inhibitors for Mycobacterium tuberculosis enzyme MshC by Patel, Krishnakant, Song, Fengling, Andreana, Peter R.

“…Mycothiol cysteine ligase (MshC) is a key enzyme in the mycothiol (MSH) biosynthesis and a promising target for developing new anti-mycobacterial compounds…”
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Synthesis of an Aminooxy Derivative of the GM3 Antigen and Its Application in Oxime Ligation by Kleski, Kristopher A, Shi, Mengchao, Lohman, Matthew, Hymel, Gabrielle T, Gattoji, Vinod K, Andreana, Peter R

“…The anomeric aminooxy GM3 trisaccharide cancer antigen (Neu5Acα2,3Galβ1,4Glcβ-ONH2) has been chemically synthesized using a linear glycosylation approach. The…”
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Chemical synthesis and immunological evaluation of entirely carbohydrate conjugate Globo H-PS A1 by Ghosh, Samir, Trabbic, Kevin R, Shi, Mengchao, Nishat, Sharmeen, Eradi, Pradheep, Kleski, Kristopher A, Andreana, Peter R

“…An anticancer, entirely carbohydrate conjugate, Globo H-polysaccharide A1 (Globo H-PS A1), was chemically prepared and immunologically evaluated in C57BL/6…”
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A One-Pot, Microwave-Influenced Synthesis of Diverse Small Molecules by Multicomponent Reaction Cascades by Santra, Soumava, Andreana, Peter R

“…Small molecule diversity can be achieved in a single synthetic operation from bifunctional substrates in the absence of additives and under the influence of…”
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Synthesis of 2,6-Dideoxysugars via Ring-Closing Olefinic Metathesis by Andreana, Peter R, McLellan, Jason S, Chen, Yongchen, Wang, Peng George

“…Grubbs' RuCl2(CHPh)(PCy3)2 (catalyst 1) and RuCl2(CHPh)(PCy3)(IMess) (catalyst 2) complexes have been successfully utilized in the construction of…”
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A Tandem One-Pot, Microwave-Assisted Synthesis of Regiochemically Differentiated 1,2,4,5-Tetrahydro-1,4-benzodiazepin-3-ones by De Silva, Ravindra A, Santra, Soumava, Andreana, Peter R

“…A one-pot, two-step synthesis of the title compounds employs a multicomponent Ugi condensation reaction, microwave irradiation, and Fe(0) as a reductant. Two…”
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