Search Results - "Andrea Marzi"

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses by Letko, Michael, Marzi, Andrea, Munster, Vincent

“…Over the past 20 years, several coronaviruses have crossed the species barrier into humans, causing outbreaks of severe, and often fatal, respiratory illness…”
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Marburg virus pathogenesis - differences and similarities in humans and animal models by Shifflett, Kyle, Marzi, Andrea

“…Marburg virus (MARV) is a highly pathogenic virus associated with severe disease and mortality rates as high as 90%. Outbreaks of MARV are sporadic, deadly,…”
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Ebola virus disease sequelae and viral persistence in animal models: Implications for the future by Durant, Olivia, Marzi, Andrea

“…Ebola virus disease (EVD), caused by infection with Ebola virus, results in severe, acute illness with a high mortality rate. As the incidence of outbreaks of…”
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Ebola: Lessons on Vaccine Development by Feldmann, Heinz, Feldmann, Friederike, Marzi, Andrea

“…The West African Ebola virus (EBOV) epidemic has fast-tracked countermeasures for this rare, emerging zoonotic pathogen. Until 2013-2014, most EBOV vaccine…”
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The Ebola virus soluble glycoprotein contributes to viral pathogenesis by activating the MAP kinase signaling pathway by Furuyama, Wakako, Shifflett, Kyle, Feldmann, Heinz, Marzi, Andrea

“…Ebola virus (EBOV) expresses three different glycoproteins (GPs) from its GP gene. The primary product, soluble GP (sGP), is secreted in abundance during…”
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Ebola Virus: Pathogenesis and Countermeasure Development by Furuyama, Wakako, Marzi, Andrea

“…Since its discovery in 1976, Ebola virus (EBOV) has caused numerous outbreaks of fatal hemorrhagic disease in Africa. The biggest outbreak on record is the…”
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Vesicular stomatitis virus-based vaccines against Lassa and Ebola viruses by Marzi, Andrea, Feldmann, Friederike, Geisbert, Thomas W, Feldmann, Heinz, Safronetz, David

“…We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)-based Lassa virus vaccine does not alter protective efficacy of subsequent…”
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K18-hACE2 mice develop respiratory disease resembling severe COVID-19 by Yinda, Claude Kwe, Port, Julia R, Bushmaker, Trenton, Offei Owusu, Irene, Purushotham, Jyothi N, Avanzato, Victoria A, Fischer, Robert J, Schulz, Jonathan E, Holbrook, Myndi G, Hebner, Madison J, Rosenke, Rebecca, Thomas, Tina, Marzi, Andrea, Best, Sonja M, de Wit, Emmie, Shaia, Carl, van Doremalen, Neeltje, Munster, Vincent J

“…SARS-CoV-2 emerged in late 2019 and resulted in the ongoing COVID-19 pandemic. Several animal models have been rapidly developed that recapitulate the…”
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The vesicular stomatitis virus-based Ebola virus vaccine: From concept to clinical trials by Suder, Ellen, Furuyama, Wakako, Feldmann, Heinz, Marzi, Andrea, de Wit, Emmie

“…The devastating Ebola virus (EBOV) epidemic in West Africa in 2013-2016 accelerated the progress of several vaccines and antivirals through clinical trials,…”
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Filovirus vaccines as a response paradigm for emerging infectious diseases by Marzi, Andrea, Feldmann, Heinz

“…Nowadays, filovirus vaccine development may be seen as a paradigm for our response capabilities to emerging and re-emerging infectious diseases. Specifically,…”
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A VSV-based Zika virus vaccine protects mice from lethal challenge by Emanuel, Jackson, Callison, Julie, Dowd, Kimberly A., Pierson, Theodore C., Feldmann, Heinz, Marzi, Andrea

“…Infection with Zika virus (ZIKV) is commonly mild in humans but has been associated with alarming negative health outcomes including Guillain-Barré syndrome in…”
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A complement component C1q-mediated mechanism of antibody-dependent enhancement of Ebola virus infection by Furuyama, Wakako, Nanbo, Asuka, Maruyama, Junki, Marzi, Andrea, Takada, Ayato

“…Besides the common Fc receptor (FcR)-mediated mechanism of antibody-dependent enhancement (ADE), Ebola virus (EBOV) is known to utilize the complement…”
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A fatty acid-ordered plasma membrane environment is critical for Ebola virus matrix protein assembly and budding by Amiar, Souad, Johnson, Kristen A., Husby, Monica L., Marzi, Andrea, Stahelin, Robert V.

“…Plasma membrane (PM) domains and order phases have been shown to play a key role in the assembly, release, and entry of several lipid-enveloped viruses. In the…”
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Antibodies are necessary for rVSV/ZEBOV-GP–mediated protection against lethal Ebola virus challenge in nonhuman primates by Marzi, Andrea, Engelmann, Flora, Feldmann, Friederike, Haberthur, Kristen, Shupert, W. Lesley, Brining, Douglas, Scott, Dana P., Geisbert, Thomas W., Kawaoka, Yoshihiro, Katze, Michael G., Feldmann, Heinz, Messaoudi, Ilhem

“…Ebola viruses cause hemorrhagic disease in humans and nonhuman primates with high fatality rates. These viruses pose a significant health concern worldwide due…”
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Lack of protection against ebola virus from chloroquine in mice and hamsters by Falzarano, Darryl, Safronetz, David, Prescott, Joseph, Marzi, Andrea, Feldmann, Friederike, Feldmann, Heinz

“…The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at…”
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Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain by Marzi, Andrea, Feldmann, Friederike, Hanley, Patrick W, Scott, Dana P, Günther, Stephan, Feldmann, Heinz

“…In late 2013, the largest documented outbreak of Ebola hemorrhagic fever started in Guinea and has since spread to neighboring countries, resulting in almost…”
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An Ebola whole-virus vaccine is protective in nonhuman primates by Marzi, Andrea, Halfmann, Peter, Hill-Batorski, Lindsay, Feldmann, Friederike, Shupert, W. Lesley, Neumann, Gabriele, Feldmann, Heinz, Kawaoka, Yoshihiro

“…Zaire ebolavirus is the causative agent of the current outbreak of hemorrhagic fever disease in West Africa. Previously, we showed that a whole Ebola virus…”
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Antiviral Innate Responses Induced by VSV-EBOV Vaccination Contribute to Rapid Protection by Menicucci, Andrea R, Jankeel, Allen, Feldmann, Heinz, Marzi, Andrea, Messaoudi, Ilhem

“…Ebola virus (EBOV) is a single-stranded RNA virus that causes Ebola virus disease (EVD), characterized by excessive inflammation, lymphocyte apoptosis,…”
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Monoclonal Antibody Cocktail Protects Hamsters From Lethal Marburg Virus Infection by Marzi, Andrea, Haddock, Elaine, Kajihara, Masahiro, Feldmann, Heinz, Takada, Ayato

“…Marburg virus (MARV), family Filoviridae, causes Marburg hemorrhagic fever (MHF) in humans and nonhuman primates with case fatality rates of up to 90%. There…”
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Development of an Enzyme-Linked Immunosorbent Assay to Determine the Expression Dynamics of Ebola Virus Soluble Glycoprotein during Infection by Furuyama, Wakako, Marzi, Andrea

“…Ebola virus (EBOV) is a highly pathogenic virus with human case fatality rates of up to 90%. EBOV uses transcriptional editing to express three different…”
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