Search Results - "Andrea, M. E."

Synthesis of many different types of organic small molecules using one automated process by Li, Junqi, Ballmer, Steven G., Gillis, Eric P., Fujii, Seiko, Schmidt, Michael J., Palazzolo, Andrea M. E., Lehmann, Jonathan W., Morehouse, Greg F., Burke, Martin D.

“…Small-molecule synthesis usually relies on procedures that are highly customized for each target. A broadly applicable automated process could greatly increase…”
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The validated embryonic stem cell test to predict embryotoxicity in vitro by Seiler, Andrea E M, Spielmann, Horst

“…In the embryonic stem cell test (EST), differentiation of mouse embryonic stem cells (mESCs) is used as a model to assess embryotoxicity in vitro . The test…”
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Automated iterative Csp3–C bond formation by Blair, Daniel J., Chitti, Sriyankari, Trobe, Melanie, Kostyra, David M., Haley, Hannah M. S., Hansen, Richard L., Ballmer, Steve G., Woods, Toby J., Wang, Wesley, Mubayi, Vikram, Schmidt, Michael J., Pipal, Robert W., Morehouse, Greg. F., Palazzolo Ray, Andrea M. E., Gray, Danielle L., Gill, Adrian L., Burke, Martin D.

“…Fully automated synthetic chemistry would substantially change the field by providing broad on-demand access to small molecules. However, the reactions that…”
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Associations between renal function, volume status and endotoxaemia in chronic kidney disease patients by Gonçalves, Simone, Pecoits-Filho, Roberto, Perreto, Sônia, Barberato, Silvio H., Stinghen, Andréa E. M., Lima, Emmanuel G. A., Fuerbringer, Roseana, Sauthier, Sirlene M., Riella, Miguel C.

“…Inflammation is an important predictor of increased cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD), but the mechanisms…”
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The Unexpected Benefits of a Decolonized Knowledge Translation Initiative for Indigenous Mother Participants by Wright, Amy, VanEvery, Rachel, Burnside, Heather, Lopez, Kristena B., Kewageshig-Fyfe, Katie, Jacobs, Brenda, Floyd, Andrea E. M., Ferron, Era M.

“…Western health research’s approach to knowledge translation (KT) has been criticized by Indigenous scholars, leaders, and communities for its misalignment with…”
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The Impact of Uremic Toxicity Induced Inflammatory Response on the Cardiovascular Burden in Chronic Kidney Disease by Claro, Ligia Maria, Moreno-Amaral, Andrea N, Gadotti, Ana Carolina, Dolenga, Carla J, Nakao, Lia S, Azevedo, Marina L V, de Noronha, Lucia, Olandoski, Marcia, de Moraes, Thyago P, Stinghen, Andréa E M, Pécoits-Filho, Roberto

“…Uremic toxin (UT) retention in chronic kidney disease (CKD) affects biological systems. We aimed to identify the associations between UT, inflammatory…”
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The Expression of Uncoupling Protein 3 Coincides With the Fatty Acid Oxidation Type of Metabolism in Adult Murine Heart by Hilse, Karolina E, Rupprecht, Anne, Egerbacher, Monika, Bardakji, Sarah, Zimmermann, Lars, Wulczyn, Andrea E M Seiler, Pohl, Elena E

“…The involvement of mitochondrial uncoupling proteins 2 and 3 in the pathogenesis of cardiovascular diseases is widely acknowledged. However, contradictory…”
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Uremia Impacts VE-Cadherin and ZO-1 Expression in Human Endothelial Cell-to-Cell Junctions by Maciel, Rayana A P, Cunha, Regiane S, Busato, Valentina, Franco, Célia R C, Gregório, Paulo C, Dolenga, Carla J R, Nakao, Lia S, Massy, Ziad A, Boullier, Agnès, Pecoits-Filho, Roberto, Stinghen, Andréa E M

“…Endothelial dysfunction in uremia can result in cell-to-cell junction loss and increased permeability, contributing to cardiovascular diseases (CVD)…”
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Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function by Rupprecht, Anne, Sittner, Dana, Smorodchenko, Alina, Hilse, Karolina E, Goyn, Justus, Moldzio, Rudolf, Seiler, Andrea E M, Bräuer, Anja U, Pohl, Elena E

“…Apart from the first family member, uncoupling protein 1 (UCP1), the functions of other UCPs (UCP2-UCP5) are still unknown. In analyzing our own results and…”
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MicroRNA profiling as tool for in vitro developmental neurotoxicity testing: the case of sodium valproate by Smirnova, Lena, Block, Katharina, Sittka, Alexandra, Oelgeschläger, Michael, Seiler, Andrea E M, Luch, Andreas

“…Studying chemical disturbances during neural differentiation of murine embryonic stem cells (mESCs) has been established as an alternative in vitro testing…”
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Lentiviral Vector Bioprocessing by Perry, Christopher, Rayat, Andrea C M E

“…Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian cells and are now commonly utilised within the growing field of…”
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Knowledge of bidirectional relationship between diabetes and periodontal disease among diabetes patients: A systematic review by Maia, Melissa Barral, Souza, João G. S., Bertolini, Martinna, Costa, Raphael C., Costa, Gustavo S., Torres, Silvério de A. S., Ferreira, Efigênia F., Martins, Andrea M. E. B. L.

“…Introduction The bidirectional relationship between diabetes mellitus and periodontal disease has been reported in the literature, suggesting that poor…”
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Neural differentiation of mouse embryonic stem cells as a tool to assess developmental neurotoxicity in vitro by Visan, Anke, Hayess, Katrin, Sittner, Dana, Pohl, Elena E., Riebeling, Christian, Slawik, Birgitta, Gulich, Konrad, Oelgeschläger, Michael, Luch, Andreas, Seiler, Andrea E.M.

“…► Method for fast and efficient differentiation of mouse stem cells into neural cells. ► Neural cells express structural proteins associated with postsynaptic…”
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Insights into product and process related challenges of lentiviral vector bioprocessing by Perry, Christopher, Mujahid, Noor, Takeuchi, Yasu, Rayat, Andrea C. M. E.

“…Lentiviral vectors (LVs) are used in advanced therapies to transduce recipient cells for long term gene expression for therapeutic benefit. The vector is…”
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An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development by Raasch, Martin, Rennert, Knut, Jahn, Tobias, Gärtner, Claudia, Schönfelder, Gilbert, Huber, Otmar, Seiler, Andrea E. M., Mosig, Alexander S.

“…The development of therapeutic substances to treat diseases of the central nervous system is hampered by the tightness and selectivity of the blood-brain…”
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Assaying embryotoxicity in the test tube: Current limitations of the embryonic stem cell test (EST) challenging its applicability domain by Riebeling, Christian, Hayess, Katrin, Peters, Annelieke K., Steemans, Margino, Spielmann, Horst, Luch, Andreas, Seiler, Andrea E. M.

“…Testing for embryotoxicity in vitro is an attractive alternative to animal experimentation. The embryonic stem cell test (EST) is such a method, and it has…”
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mirDIP 4.1-integrative database of human microRNA target predictions by Tokar, Tomas, Pastrello, Chiara, Rossos, Andrea E M, Abovsky, Mark, Hauschild, Anne-Christin, Tsay, Mike, Lu, Richard, Jurisica, Igor

“…Abstract MicroRNAs are important regulators of gene expression, achieved by binding to the gene to be regulated. Even with modern high-throughput technologies,…”
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Effect of PKC-β Signaling Pathway on Expression of MCP-1 and VCAM-1 in Different Cell Models in Response to Advanced Glycation End Products (AGEs) by Rempel, Lisienny C T, Finco, Alessandra B, Maciel, Rayana A P, Bosquetti, Bruna, Alvarenga, Larissa M, Souza, Wesley M, Pecoits-Filho, Roberto, Stinghen, Andréa E M

“…Advanced glycation end products (AGEs) are compounds classified as uremic toxins in patients with chronic kidney disease that have several pro-inflammatory…”
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The DNT-EST: A predictive embryonic stem cell-based assay for developmental neurotoxicity testing in vitro by Hayess, Katrin, Riebeling, Christian, Pirow, Ralph, Steinfath, Matthias, Sittner, Dana, Slawik, Birgitta, Luch, Andreas, Seiler, Andrea E.M

“…Abstract As the developing brain is exquisitely vulnerable to chemical disturbances, testing for developmental neurotoxicity of a substance is an important…”
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Loss of CDK5RAP2 affects neural but not non-neural mESC differentiation into cardiomyocytes by Kraemer, Nadine, Ravindran, Ethiraj, Zaqout, Sami, Neubert, Gerda, Schindler, Detlev, Ninnemann, Olaf, Gräf, Ralph, Seiler, Andrea E M, Kaindl, Angela M

“…Biallelic mutations in the gene encoding centrosomal CDK5RAP2 lead to autosomal recessive primary microcephaly (MCPH), a disorder characterized by pronounced…”
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