Search Results - "Andre, Valerie"

Management of Abemaciclib‐Associated Adverse Events in Patients with Hormone Receptor‐Positive, Human Epidermal Growth Factor Receptor 2‐Negative Advanced Breast Cancer: Safety Analysis of MONARCH 2 and MONARCH 3 by Rugo, Hope S., Huober, Jens, García‐Sáenz, José A., Masuda, Norikazu, Sohn, Joo Hyuk, Andre, Valerie A.M., Barriga, Susana, Cox, Joanne, Goetz, Matthew

“…Background Abemaciclib demonstrated efficacy in hormone receptor‐positive, human epidermal growth factor receptor 2‐negative advanced breast cancer. Here we…”
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Abemaciclib plus endocrine therapy for hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer (monarchE): results from a preplanned interim analysis of a randomised, open-label, phase 3 trial by Johnston, Stephen R D, Toi, Masakazu, O'Shaughnessy, Joyce, Rastogi, Priya, Campone, Mario, Neven, Patrick, Huang, Chiun-Sheng, Huober, Jens, Jaliffe, Georgina Garnica, Cicin, Irfan, Tolaney, Sara M, Goetz, Matthew P, Rugo, Hope S, Senkus, Elzbieta, Testa, Laura, Del Mastro, Lucia, Shimizu, Chikako, Wei, Ran, Shahir, Ashwin, Munoz, Maria, San Antonio, Belen, André, Valérie, Harbeck, Nadia, Martin, Miguel

“…Adjuvant abemaciclib plus endocrine therapy previously showed a significant improvement in invasive disease-free survival and distant relapse-free survival in…”
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Management of Abemaciclib‐Associated Adverse Events in Patients with Hormone Receptor‐Positive, Human Epidermal Growth Factor Receptor 2‐Negative Advanced Breast Cancer: Safety Analysis of MONARCH 2 and MONARCH 3 by Rugo, Hope S., Huober, Jens, García‐Sáenz, José A., Masuda, Norikazu, Sohn, Joo Hyuk, Andre, Valerie A.M., Barriga, Susana, Cox, Joanne, Goetz, Matthew

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Adjuvant Abemaciclib Plus Endocrine Therapy for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative, High-Risk Early Breast Cancer: Results From a Preplanned monarchE Overall Survival Interim Analysis, Including 5-Year Efficacy Outcomes by Rastogi, Priya, O'Shaughnessy, Joyce, Martin, Miguel, Boyle, Frances, Cortes, Javier, Rugo, Hope S, Goetz, Matthew P, Hamilton, Erika P, Huang, Chiun-Sheng, Senkus, Elzbieta, Tryakin, Alexey, Cicin, Irfan, Testa, Laura, Neven, Patrick, Huober, Jens, Shao, Zhimin, Wei, Ran, André, Valérie, Munoz, Maria, San Antonio, Belen, Shahir, Ashwin, Harbeck, Nadia, Johnston, Stephen

“…JCO Two years of adjuvant abemaciclib combined with endocrine therapy (ET) resulted in a significant improvement in invasive disease-free survival (IDFS) and…”
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A phase I and pharmacokinetic study of taladegib, a Smoothened inhibitor, in Japanese patients with advanced solid tumors by Ueno, Hideki, Kondo, Shunsuke, Yoshikawa, Shusuke, Inoue, Koichi, Andre, Valérie, Tajimi, Masaomi, Murakami, Haruyasu

“…Summary Background This phase I dose-escalation study investigated the safety of the Smoothened inhibitor taladegib in Japanese patients with advanced solid…”
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Tumor Survivin Is Downregulated by the Antisense Oligonucleotide LY2181308: A Proof-of-Concept, First-in-Human Dose Study by TALBOT, Denis C, RANSON, Malcolm, MCHUGH, Peter J, DE BONO, Johann S, MATTHEWS, Julian, SALEEM, Azeem, PRICE, Patricia, DAVIES, Joanna, LAHN, Michael, CALLIES, Sophie, ANDRE, Valérie, KADAM, Sunil, BURGESS, Michael, SLAPAK, Christopher, OLSEN, Anna L

“…Enhanced tumor cell survival through expression of inhibitors of apoptosis (IAP) is a hallmark of cancer. Survivin, an IAP absent from most normal tissues, is…”
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A Randomised Phase 2 Study Combining LY2181308 Sodium (Survivin Antisense Oligonucleotide) with First-line Docetaxel/Prednisone in Patients with Castration-resistant Prostate Cancer by Wiechno, Paweł, Somer, Bradley G, Mellado, Begoña, Chłosta, Piotr L, Cervera Grau, José Manuel, Castellano, Daniel, Reuter, Christoph, Stöckle, Michael, Kamradt, Jörn, Pikiel, Joanna, Durán, Ignacio, Wedel, Steffen, Callies, Sophie, André, Valérie, Hurt, Karla, Brown, Jacqueline, Lahn, Michael, Heinrich, Bernhard

“…Abstract Castration-resistant prostate cancer (CRPC) is partially characterised by overexpression of antiapoptotic proteins, such as survivin. In this phase 2…”
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Real-world survival outcomes of heavily pretreated patients with refractory HR+, HER2−metastatic breast cancer receiving single-agent chemotherapy—a comparison with MONARCH 1 by Rugo, Hope S., Dieras, Veronique, Cortes, Javier, Patt, Debra, Wildiers, Hans, O’Shaughnessy, Joyce, Zamora, Esther, Yardley, Denise A., Carter, Gebra Cuyun, Sheffield, Kristin M., Li, Li, Andre, Valerie A. M., Li, Xiaohong I., Frenzel, Martin, Huang, Yu-Jing, Dickler, Maura N., Tolaney, Sara M.

“…Purpose In MONARCH 1 (NCT02102490), single-agent abemaciclib demonstrated promising efficacy activity and tolerability in a population of heavily pretreated…”
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Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin by Dos Santos, Morgan, Michopoulou, Anna, André-Frei, Valérie, Boulesteix, Sophie, Guicher, Christine, Dayan, Guila, Whitelock, John, Damour, Odile, Rousselle, Patricia

“…The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal-epidermal junction, a cell…”
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Impact of dose reductions on adjuvant abemaciclib efficacy for patients with high-risk early breast cancer: analyses from the monarchE study by Goetz, Matthew P., Cicin, Irfan, Testa, Laura, Tolaney, Sara M., Huober, Jens, Guarneri, Valentina, Johnston, Stephen R. D., Martin, Miguel, Rastogi, Priya, Harbeck, Nadia, Shahir, Ashwin, Wei, Ran, André, Valérie, Rugo, Hope S., O’Shaughnessy, Joyce

“…In monarchE, adjuvant abemaciclib significantly improved invasive disease-free survival (IDFS) and distant relapse-free survival (DRFS), with sustained benefit…”
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Development of new 3D human ex vivo models to study sebaceous gland lipid metabolism and modulations by Bengy, Anne‐France, Forraz, Nico, Danoux, Louis, Berthelemy, Nicolas, Cadau, Sébastien, Degoul, Olivier, Andre, Valérie, Pain, Sabine, McGuckin, Colin

“…Objectives Sebaceous glands maintain skin homeostasis by producing sebum. Low production can induce hair loss and fragile skin. Overproduction provokes…”
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Oral Administration of Gemcitabine in Patients with Refractory Tumors: A Clinical and Pharmacologic Study by Veltkamp, Stephan A, Jansen, Robert S, Callies, Sophie, Pluim, Dick, Visseren-Grul, Carla M, Rosing, Hilde, Kloeker-Rhoades, Susanne, Andre, Valerie A M, Beijnen, Jos H, Slapak, Christopher A, Schellens, Jan H M

“…Purpose: To determine the toxicity, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of oral gemcitabine…”
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A new organotypic model containing dermal-type macrophages by Bechetoille, Nicolas, Vachon, Hortense, Gaydon, Amandine, Boher, Aurelie, Fontaine, Thomas, Schaeffer, Evelyne, Decossas, Marion, André-Frei, Valérie, Mueller, Christopher G.

“…:  Human skin equivalents (SEs) are popular three‐dimensional (D) cell culture systems in fundamental and applied dermatology. They have been made to contain…”
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Phase I Study of Docetaxel in Combination with the P-Glycoprotein Inhibitor, Zosuquidar, in Resistant Malignancies by FRACASSE, Paula M, GOLDSTEIN, Lori J, BURGESS, Michael F, SLAPAK, Christopher A, SCHELLENS, Jan H. M, DE ALWIS, Dinesh P, RADER, Janet S, ARQUETTE, Matthew A, GOODNER, Sherry A, WRIGHT, Lisa P, FEARS, Carole L, GAZAK, Robert J, ANDRE, Valerie A. M

“…Purpose: To determine the maximum tolerated dose, dose-limiting toxicity, and pharmacokinetics of docetaxel infused over 1 hour when given in combination with…”
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Facial Skin Microbiome Composition and Functional Shift with Aging by Garlet, Allison, Andre-Frei, Valerie, Del Bene, Nicolas, Cameron, Hunter James, Samuga, Anita, Rawat, Vimal, Ternes, Philipp, Leoty-Okombi, Sabrina

“…The change in the skin microbiome as individuals age is only partially known. To provide a better understanding of the impact of aging, whole-genome sequencing…”
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Expression of estrogen-related receptor beta (ERRβ) in human skin by KRAHN-BERTIL, Elodie, DOS SANTOS, Morgan, DAMOUR, Odile, ANDRE, Valérie, BOLZINGER, Marie-Alexandrine

“…Skin is a non classical target tissue for estrogens, whose biological and mechanical properties are affected by the hormonal deprivation occurring at the…”
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Expression of estrogen-related receptor gamma (ERRy) in human skin by KRAHN-BERTIL, Elodie, BOLZINGER, Marie-Alexandrine, ANDRE, Valérie, ORLY, Isabelle, KANITAKIS, Jean, ROUSSELLE, Patricia, DAMOUR, Odile

“…Skin is a non-classical target for estrogens. Despite evidence showing that estrogen receptors (ER) are expressed in skin, there are still extensive gaps in…”
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Epidermal keratin 5 expression and distribution is under dermal influence by Cario, Muriel, Pain, Catherine, Kaulanjan‐Checkmodine, Priscilla, Masia, Daniela, Delia, Gabriele, Casoli, Vincent, Costet, Pierre, Goussot, Jean‐François, Guyonnet‐Duperat, Véronique, Bibeyran, Alice, Ezzedine, Khaled, Reymermier, Corinne, Andre‐Frei, Valérie, Taieb, Alain

“…Human skin melanin pigmentation is regulated by systemic and local factors. According to the type of melanin produced by melanocytes, the transfer and…”
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In vitro glycation of an endothelialized and innervated tissue-engineered skin to screen anti-AGE molecules by Cadau, Sébastien, Leoty-Okombi, Sabrina, Pain, Sabine, Bechetoille, Nicolas, André-Frei, Valérie, Berthod, François

“…Abstract Glycation is one of the major processes responsible for skin aging through induction of the detrimental formation of advanced glycation end-products…”
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Thymidylate synthase expression and outcome of patients receiving pemetrexed for advanced nonsquamous non-small-cell lung cancer in a prospective blinded assessment phase II clinical trial by Nicolson, Marianne C, Fennell, Dean A, Ferry, David, O'Byrne, Kenneth, Shah, Riyaz, Potter, Vanessa, Skailes, Geraldine, Upadhyay, Sunil, Taylor, Paul, André, Valerie, Nguyen, Tuan S, Myrand, Scott P, Visseren-Grul, Carla, Das, Mayukh, Kerr, Keith M

“…In retrospective analyses of patients with nonsquamous non-small-cell lung cancer treated with pemetrexed, low thymidylate synthase (TS) expression is…”
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