A Single Dose of Ginkgo biloba Extract Induces Gene Expression of Hypothalamic Anorexigenic Effectors in Male Rats

A Single Dose of Ginkgo biloba Extract Induces Gene Expression of Hypothalamic Anorexigenic Effectors in Male Rats

Previous studies have shown that extract (GbE) reduces food intake and body mass gain and regulates proteins related to lipid metabolism in obese rats. In ovariectomized rats, GbE restored the hippocampal and hypothalamic serotonergic system activity, favoring the spontaneous feeding decrement. Cons...

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Bibliographic Details
Published in:Brain sciences Vol. 11; no. 12; p. 1602
Main Authors: Machado, Meira M F, Pereira, Janilda P, Hirata, Bruna K S, Júlio, Viviane S, Banin, Renata M, Andrade, Heider M, Ribeiro, Eliane B, Cerutti, Suzete M, Telles, Mônica M
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 02-12-2021
MDPI
Subjects:
Animals
Appetite
Body mass
Cocaine- and amphetamine-regulated transcript protein
Energy
Feeding behavior
Flavonoids
Food
Food intake
food intake GbE
Gene expression
Ginkgo biloba
Hippocampus
Homeostasis
hypothalamic neuropeptides
Hypothalamus
Leptin
Lipid metabolism
Neuropeptide Y
Neuropeptides
Ovariectomy
Proopiomelanocortin
Proteins
serotonergic system
Serotonin
Serotonin receptors
Serotonin S1 receptors
Serotonin S2 receptors
United States > US
Pittsburgh Pennsylvania
serotonergic system
hypothalamic neuropeptides
food intake GbE
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Summary:Previous studies have shown that extract (GbE) reduces food intake and body mass gain and regulates proteins related to lipid metabolism in obese rats. In ovariectomized rats, GbE restored the hippocampal and hypothalamic serotonergic system activity, favoring the spontaneous feeding decrement. Considering the promising hypophagic effect of GbE, this study aimed to investigate the effect of a single acute dose on hypothalamic pathways that regulate feeding behavior in male rats. Four-month-old Wistar male rats received either a single acute oral GbE dose (500 mg/kg) or vehicle. Food intake and body mass were measured after 1, 4, 12, and 24 h. Rats were euthanized, and hypothalami were removed for mRNA quantification of anorexigenic (POMC/CART) and orexigenic (AgRP/NPY) neuropeptides, leptin/serotonin receptors (5HT1A, 5HT1B, 5HT2C), and serotonin transporters. We also investigated POMC, 5-HT1B, and 5-HT2C protein levels. A single acute GbE dose induced the hypothalamic POMC, CART, and 5-HT2C gene expression but failed to modify orexigenic effectors. No alterations in food intake, body mass, and hypothalamic protein levels were observed. In summary, the present findings demonstrate the rapid stimulation of pivotal hypothalamic anorexigenic pathways in response to a single GbE administration, reinforcing the GbE hypophagic activity. However, more studies are necessary to evaluate its potential as an appetite modulator.
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The authors have equally contributed to this work.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci11121602