Molecular basis and clinical perspectives of deep brain stimulation for major depressive disorder

It is possible to consider the stimulation of the cingulate gyrus in its portion below the corpus callosum (SCC, or subcallosal cingulate cortex) as an effective, promising, and safe alternative intervention for treatment-resistant depression. In studies with deep brain stimulation - DBS, when follo...

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Published in:	Journal of cerebral blood flow and metabolism Vol. 42; no. 4; pp. 683 - 685
Main Authors:	Teixeira, Saulo Araújo, Moreira, Jorge Lucas de Sousa, Sousa, Narah Régia Tavares, Pereira, Andrezza Maria de Carvalho, Rodrigues, Paloma Nóbrega, Santos, Adriano Siqueira dos, Andrade, Ana Maria Lima Carneiro de, Rolim Neto, Modesto Leite, Araújo, Jaime Emanuel Brito, Machado, Sávio Samuel Feitosa, Vieira, Nélio Barreto, Lima, Danielly Gonçalves Sombra, Filho, Francisco Helder Pereira
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-04-2022
Subjects:	Deep Brain Stimulation - methods Depressive Disorder, Major - diagnostic imaging Depressive Disorder, Major - pathology Depressive Disorder, Major - therapy Depressive Disorder, Treatment-Resistant - diagnostic imaging Depressive Disorder, Treatment-Resistant - pathology Depressive Disorder, Treatment-Resistant - therapy Gyrus Cinguli - physiology Humans Positron Emission Tomography Computed Tomography neuro-psychiatry neurosurgical procedures deep brain stimulation – DBS positron emission tomography–computed tomography – PET-CT Major depressive disorder – MDD
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Summary:	It is possible to consider the stimulation of the cingulate gyrus in its portion below the corpus callosum (SCC, or subcallosal cingulate cortex) as an effective, promising, and safe alternative intervention for treatment-resistant depression. In studies with deep brain stimulation - DBS, when follow-on with functional magnetic resonance imaging and/or PET-CT (Positron emission tomography–computed tomography) is performed, it is observed an increase in the blood supply and glucose metabolism in this region, which is the anterior part of the limbic system. This same location has good experimental results also for the treatment of anorexia nervosa. The hypotheses suggest a greater activation of the reward system, a greater sense of well-being, and a consequent reduction in depressive symptoms, the objective of the treatment. Over the last 20 years, multicenter studies have shown symptomatic improvement in 50–60% of patients, and about a third even reach criteria for remission of the depressive disorder.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0271-678X 1559-7016
DOI:	10.1177/0271678X221074279