Search Results - "Andrés, J.P."

Stroma-Derived Three-Dimensional Matrices Are Necessary and Sufficient to Promote Desmoplastic Differentiation of Normal Fibroblasts by Amatangelo, Michael D., Bassi, Daniel E., Klein-Szanto, Andrés J.P., Cukierman, Edna

“…Stromagenesis is a host reaction of connective tissue that, when induced in cancer, produces a progressive and permissive mesenchymal microenvironment, thereby…”
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Martensitic transformation, magnetic and magnetocaloric properties of Ni–Mn–Fe–Sn Heusler ribbons by Deltell, A., Mohamed, Abd El-Moez A., Álvarez-Alonso, P., Ipatov, M., Andrés, J.P., González, J.A., Sánchez, T., Zhukov, A., Escoda, M.L., Suñol, J.J., López Antón, R.

“…Melt-spun ribbons of nominal composition Ni50Mn36-xFexSn14 (x = 0, 2, and 3) were prepared by melt-spinning. The alloys undergo a martensitic transformation…”
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Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis by Goetz, Jacky G., Minguet, Susana, Navarro-Lérida, Inmaculada, Lazcano, Juan José, Samaniego, Rafael, Calvo, Enrique, Tello, Marta, Osteso-Ibáñez, Teresa, Pellinen, Teijo, Echarri, Asier, Cerezo, Ana, Klein-Szanto, Andres J.P., Garcia, Ricardo, Keely, Patricia J., Sánchez-Mateos, Paloma, Cukierman, Edna, Del Pozo, Miguel A.

“…Mechanotransduction is a key determinant of tissue homeostasis and tumor progression. It is driven by intercellular adhesions, cell contractility, and forces…”
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Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin by LOPEZ DE CICCO, Ricardo, BASSI, Daniel E, ZUCKER, Stanley, SEIDAH, Nabil G, KLEIN-SZANTO, Andrés J. P

“…Furin, a potent proprotein convertase involved in activation of several cancer-related substrates, is synthesized as an inactive zymogen, thus minimizing the…”
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Inhibition of proprotein convertases: Approaches to block squamous carcinoma development and progression by de Cicco, Ricardo López, Bassi, Daniel E., Benavides, Fernando, Conti, Claudio J., Klein-Szanto, Andrés J.P.

“…Most proprotein convertase (PC) inhibitors are compounds that act as competitive inhibitors. All of them contain the general cleavage motif RXK/RR that binds…”
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Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors by RUDNICK, Stephen I, JIANLONG LOU, SHALLER, Calvin C, YONG TANG, KLEIN-SZANTO, Andres J. P, WEINER, Louis M, MARKS, James D, ADAMS, Gregory P

“…Antibody drugs are widely used in cancer therapy, but conditions to maximize tumor penetration and efficacy have yet to be fully elucidated. In this study, we…”
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PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers by Li, Yan, Chitnis, Nilesh, Nakagawa, Hiroshi, Kita, Yoshiaki, Natsugoe, Shoji, Yang, Yi, Li, Zihai, Wasik, Mariusz, Klein-Szanto, Andres J P, Rustgi, Anil K, Diehl, J Alan

“…Protein arginine methyltransferase 5 (PRMT5) has been implicated as a key modulator of lymphomagenesis. Whether PRMT5 has overt oncogenic function in the…”
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TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis by Finnberg, Niklas, Klein-Szanto, Andres J P, El-Deiry, Wafik S

“…Preclinical data support the potential of the death-signaling receptors for TRAIL as targets for cancer therapy. However, it is unclear whether these…”
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Proprotein convertases: "Master switches" in the regulation of tumor growth and progression by Bassi, Daniel E., Fu, Jian, Lopez de Cicco, Ricardo, Klein-Szanto, Andres J.P.

“…Proprotein convertases (PCs) are a group of Ca2+‐dependent serine proteases that have homology to the endoproteases subtilisin (bacteria) and kexin (yeast)…”
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p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model by HOI YEE CHOW, JUBB, Adrian M, SILVIO GUTKIND, J, HOEFLICH, Klaus P, CHERNOFF, Jonathan, KOCH, Jennifer N, JAFFER, Zahara M, STEPANOVA, Dina, CAMPBELL, David A, DURON, Sergio G, O'FARRELL, Marie, CAI, Kathy Q, KLEIN-SZANTO, Andres J. P

“…The RAS genes are the most commonly mutated oncogenes in human cancer and present a particular therapeutic dilemma, as direct targeting of Ras proteins by…”
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Phase II Study of Erlotinib in Patients With Malignant Pleural Mesothelioma: A Southwest Oncology Group Study by GARLAND, Linda L, RANKIN, Cathryn, GANDARA, David R, RIVKIN, Saul E, SCOTT, Katherine M, NAGLE, Raymond B, KLEIN-SZANTO, Andres J. P, TESTA, Joseph R, ALTOMARE, Deborah A, BORDEN, Ernest C

“…Malignant pleural mesothelioma (MPM) expresses high levels of epidermal growth factor receptor (EGFR), and preclinical studies have identified antitumor…”
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Hypoxia activates the cyclooxygenase-2–prostaglandin E synthase axis by Lee, James J., Natsuizaka, Mitsuteru, Ohashi, Shinya, Wong, Gabrielle S., Takaoka, Munenori, Michaylira, Carmen Z., Budo, Daniela, Tobias, John W., Kanai, Michiyuki, Shirakawa, Yasuhiro, Naomoto, Yoshio, Klein-Szanto, Andres J.P., Haase, Volker H., Nakagawa, Hiroshi

“…Hypoxia-inducible factors (HIFs), in particular HIF-1α, have been implicated in tumor biology. However, HIF target genes in the esophageal tumor…”
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Stripe domains in electrodeposited Ni90Fe10 thin films by Cotón, N., Andrés, J.P., Molina, E., Jaafar, M., Ranchal, R.

“…[Display omitted] •Electrodeposition of Ni90Fe10 magnetoelastic alloys.•Stripe domains formation tuned by magnetic stirring during growth.•Magnetostriction…”
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Transgenic Overexpression of the Proprotein Convertase Furin Enhances Skin Tumor Growth by Fu, Jian, Bassi, Daniel E, Zhang, Jirong, Li, Tianyu, Nicolas, Emmanuelle, Klein-Szanto, Andres J.P

“…Furin, one of the members of the family of proprotein convertases (PCs), ubiquitously expressed as a type I membrane-bound proteinase, activates several…”
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Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice by FEDELE, Monica, FIDANZA, Vincenzo, BALDASSARRE, Gustavo, ARRA, Claudio, VIGLIETTO, Giuseppe, INDOLFI, Ciro, CROCE, Carlo M, FUSCO, Alfredo, BATTISTA, Sabrina, PENTIMALLI, Francesca, KLEIN-SZANTO, Andres J. P, VISONE, Rosa, DE MARTINO, Ivana, CURCIO, Antonio, MORISCO, Carmine, DEL VECCHIO, Luigi

“…The HMGA1 protein is a major factor in chromatin architecture and gene control. It plays a critical role in neoplastic transformation. In fact, blockage of…”
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Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis by Shatalova, Ekaterina G, Klein-Szanto, Andres J P, Devarajan, Karthik, Cukierman, Edna, Clapper, Margie L

“…Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer in the United States. The goal of this study was to evaluate the…”
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Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous ras by KIM, Seok-Hyun, NAKAGAWA, Hiroshi, NAVARAJ, Arunasalam, NAOMOTO, Yoshio, KLEIN-SZANTO, Andres J. P, RUSTGI, Anil K, EL-DEIRY, Wafik S

“…To investigate pathways of human esophageal squamous cell transformation, we generated esophageal tumor cells using human telomerase- and SV40-immortalized…”
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Stromelysin‐1/matrix metalloproteinase‐3 (MMP‐3) expression accounts for invasive properties of human astrocytoma cell lines by Mercapide, Javier, Lopez De Cicco, Ricardo, Castresana, Javier S., Klein‐Szanto, Andres J.P.

“…Tumor invasiveness is an intrinsic feature of most glial tumors that accounts for their malignant and locally destructive nature. We evaluated the subcutaneous…”
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Direct Correlation between Proliferative Activity and Dysplasia in Pancreatic Intraepithelial Neoplasia (PanIN): Additional Evidence for a Recently Proposed Model of Progression by Klein, Walter M, Hruban, Ralph H, Klein-Szanto, Andres J P, Wilentz, Robb E

“…A growing body of morphological, clinical, and genetic observations suggests a progression model for pancreatic ductal adenocarcinoma. In this model,…”
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Disruption of the DT Diaphorase (NQO1) Gene in Mice Leads to Increased Menadione Toxicity by Radjendirane, V, Joseph, P, Lee, Y H, Kimura, S, Klein-Szanto, A J, Gonzalez, F J, Jaiswal, A K

“…NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoenzyme that catalyzes two-electron reductive metabolism and detoxification of quinones and their derivatives…”
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