Search Results - "André, Guilhem"
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A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning
Published in Journal of medicinal chemistry (24-03-2022)“…Recent events demonstrated that organophosphorus nerve agents are a serious threat for civilian and military populations. The current therapy includes a…”
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How does organophosphorus chemical warfare agent exposure affect respiratory physiology in mice?
Published in Toxicology (Amsterdam) (01-09-2024)“…In the absence of appropriate medical care, exposure to organophosphorus nerve agents, such as VX, can lead to respiratory failure, and potentially death by…”
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No-observed-adverse-effect-level (NOAEL) assessment as an optimized dose of cholinesterase reactivators for the treatment of exposure to warfare nerve agents in mice
Published in Chemico-biological interactions (01-04-2024)“…Despite the international convention on the prohibition of chemical weapons ratified in 1997, the threat of conflicts and terrorist attacks involving such…”
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An Antidote Screening System for Organophosphorus Poisoning Using Zebrafish Larvae
Published in ACS chemical neuroscience (04-08-2021)“…Organophosphorus (OP) cholinesterase inhibitors, which include insecticides and chemical warfare nerve agents, are very potent neurotoxicants. Given that the…”
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An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice
Published in Chemico-biological interactions (01-04-2017)“…Organophosphorus nerve agents, like VX, are highly toxic due to their strong inhibition potency against acetylcholinesterase (AChE). AChE inhibited by VX can…”
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Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime
Published in Biomolecules (Basel, Switzerland) (04-06-2020)“…(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to…”
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Characterization of seizures induced by acute exposure to an organophosphate herbicide, glufosinate-ammonium
Published in Neuroreport (04-05-2016)“…Glufosinate-ammonium (GLA), the active component of a widely used herbicide, induces convulsions in rodents and humans. In mouse, intraperitoneal treatment…”
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Chronic exposure to glufosinate-ammonium induces spatial memory impairments, hippocampal MRI modifications and glutamine synthetase activation in mice
Published in Neurotoxicology (Park Forest South) (01-07-2008)“…Glufosinate-ammonium (GLA), the active compound of a worldwide-used herbicide, acts by inhibiting the plant glutamine synthetase (GS) leading to a lethal…”
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MRI Characterization of Structural Mouse Brain Changes in Response to Chronic Exposure to the Glufosinate Ammonium Herbicide
Published in Toxicological sciences (01-10-2009)“…Glufosinate ammonium (GLA) is the active component of herbicides widely used in agriculture, truck farming, or public domains. GLA acts by inhibiting the plant…”
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Alteration of Asian lacquer: in-depth insight using a physico-chemical multiscale approach
Published in Analyst (London) (07-10-2013)“…Oriental lacquer has been used in Asian countries for thousands of years as a durable and aesthetic coating material for its adhesive, consolidating,…”
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Respiratory failure triggered by cholinesterase inhibitors may involve activation of a reflex sensory pathway by acetylcholine spillover
Published in Toxicology (Amsterdam) (01-08-2019)“…[Display omitted] •Inhibition of cholinesterase by organophosphate poisoning strongly impacts respiration patterns.•Long pauses after inspiration are mainly…”
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Pharmacological blockade of dopamine D2 receptors by aripiprazole is not associated with striatal sensitization
Published in Naunyn-Schmiedeberg's archives of pharmacology (2011)“…The partial agonist profile of novel antipsychotics such as aripiprazole has hardly been demonstrated in biochemical assays on animal tissues. As it is…”
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Immunomodulatory influence of bone marrow-derived mesenchymal stem cells on neuroinflammation in astrocyte cultures
Published in Journal of neuroimmunology (15-08-2012)“…Abstract The therapeutic benefits associated with mesenchymal stem cells (MSCs) largely result from their immunomodulatory and neurotrophic properties. In this…”
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Early ALS-type gait abnormalities in AMP-dependent protein kinase-deficient mice suggest a role for this metabolic sensor in early stages of the disease
Published in Metabolic brain disease (01-12-2015)“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective loss of motoneurons. While the principal cause of the disease…”
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A decade of French effort in the quest for a broad spectrum and centrally active reactivator
Published in Arhiv za higijenu rada i toksikologiju (01-07-2018)Get full text
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Une tombe princière Xiongnu à Gol Mod, Mongolie (campagnes de fouilles 2000-2001)
Published in Arts asiatiques (Paris) (01-01-2002)“…André Guilhem, Desroches Jean-Paul. Une tombe princière Xiongnu à Gol Mod, Mongolie (campagnes de fouilles 2000-2001). In: Arts asiatiques, tome 57, 2002. pp…”
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Histomorphometric comparison of three bioabsorbable GTR barrier membranes in the canine model
Published in The International journal of periodontics & restorative dentistry (01-02-2005)“…Guided tissue regeneration (GTR) using bioabsorbable barrier membranes has shown promising and somewhat predictable clinical results. However, limited…”
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L'un des plus anciens papiers du monde exhumé récemment en Mongolie — découverte, analyses physico-chimiques et contexte scientifique
Published in Arts asiatiques (Paris) (01-01-2010)“…Les découvertes de papier antique demeurent très rares en Asie orientale, l'existence de ce matériau est toutefois attestée en Chine par des fouilles…”
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"Amyloid fibrils" in the urinary sediment
Published in The New England journal of medicine (30-03-1978)Get more information
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