Search Results - "Andonopoulos, Andrew P."

The Emerging Role of Dickkopf-1 in Bone Biology: Is It the Main Switch Controlling Bone and Joint Remodeling? by Daoussis, Dimitrios, MD, Andonopoulos, Andrew P., MD, FACP

“…Background Dickkopf-1 (DKK-1), an inhibitor of the Wnt pathway, has recently emerged as an important player in several critical aspects of bone biology…”
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Treatment of Systemic Sclerosis-Associated Calcinosis: A Case Report of Rituximab-Induced Regression of CREST-Related Calcinosis and Review of the Literature by Daoussis, Dimitrios, MD, Antonopoulos, Ioannis, MD, Liossis, Stamatis-Nick C., MD, Yiannopoulos, Georgios, MD, Andonopoulos, Andrew P., MD, FACP

“…Objectives Calcinosis is frequently encountered in patients with systemic sclerosis (SSc) and may be associated with significant morbidity. No treatment has…”
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ACTH as a treatment for acute crystal-induced arthritis: Update on clinical evidence and mechanisms of action by Daoussis, Dimitrios, MD, Antonopoulos, Ioannis, MD, Andonopoulos, Andrew P., MD, FACP

“…Abstract Background ACTH, a member of the melanocortin group of proteins, has long been used in the treatment of gout and is considered as an alternative…”
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Wnt Pathway and IL-17: Novel Regulators of Joint Remodeling in Rheumatic Diseases. Looking Beyond the RANK-RANKL-OPG Axis by Daoussis, Dimitrios, MD, Andonopoulos, Andrew P., MD, FACP, Liossis, Stamatis-Nick C., MD

“…Objectives During the last decade research has focused on the RANK-RANKL-OPG (Receptor Activator of Nuclear factor KappaB-Receptor Activator of Nuclear factor…”
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Anti-TNFα treatment decreases the previously increased serum Indian Hedgehog levels in patients with ankylosing spondylitis and affects the expression of functional Hedgehog pathway target genes by Daoussis, Dimitrios, MD, Filippopoulou, Alexandra, MD, Liossis, Stamatis-Nick, MD, Sirinian, Chaido, PhD, Klavdianou, Kalliopi, MD, Bouris, Panagiotis, MSc, Karamanos, Nikos K., PhD, Andonopoulos, Andrew P., MD, FACP

“…Abstract Objective Indian Hedgehog (Ihh) is the ligand that activates the Hedgehog pathway (HH) in the skeleton—the main controller of endochondral…”
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Is There a Role for B-cell Depletion as Therapy for Scleroderma? A Case Report and Review of the Literature by Daoussis, Dimitrios, MD, Liossis, Stamatis-Nick C., MD, Tsamandas, Athanassios C., MD, Kalogeropoulou, Christina, MD, Kazantzi, Alexandra, MD, Korfiatis, Panagiotis, MSc, Yiannopoulos, Georgios, MD, Andonopoulos, Andrew P., MD, FACP

“…Objectives Rituximab (RTX) has been successfully used in the treatment of several rheumatic diseases with an acceptable safety profile. We present herein a…”
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A multicenter, open-label, comparative study of B-cell depletion therapy with Rituximab for systemic sclerosis-associated interstitial lung disease by Daoussis, Dimitrios, Melissaropoulos, Konstantinos, Sakellaropoulos, Georgios, Antonopoulos, Ioannis, Markatseli, Theodora E., Simopoulou, Theodora, Georgiou, Panagiotis, Andonopoulos, Andrew P., Drosos, Alexandros A., Sakkas, Lazaros, Liossis, Stamatis-Nick

“…Rituximab (RTX) may favorably affect lung function and skin fibrosis in patients with systemic sclerosis (SSc). We aimed to assess long-term efficacy and…”
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B-Cell Depletion Therapy in Systemic Sclerosis: Experimental Rationale and Update on Clinical Evidence by Andonopoulos, Andrew P., Yiannopoulos, Georgios, Liossis, Stamatis-Nick C., Daoussis, Dimitrios

“…Systemic sclerosis (SSc) is a systemic rheumatic disease with poor prognosis since therapeutic options are limited. Recent evidence from animal models suggests…”
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Targeting CD40L: a promising therapeutic approach by Daoussis, Dimitris, Andonopoulos, Andrew P, Liossis, Stamatis-Nick C

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Antibodies to aquaporins are frequent in patients with primary Sjögren's syndrome by Tzartos, John S, Stergiou, Christos, Daoussis, Dimitrios, Zisimopoulou, Paraskevi, Andonopoulos, Andrew P, Zolota, Vassiliki, Tzartos, Socrates J

“…Several aquaporins (AQPs) are present in the salivary glands, likely contributing to their secretions. AQP dysfunction may contribute to the salivary gland…”
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Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study by Daoussis, Dimitrios, Liossis, Stamatis-Nick C., Tsamandas, Athanassios C., Kalogeropoulou, Christina, Kazantzi, Alexandra, Sirinian, Chaido, Karampetsou, Maria, Yiannopoulos, Georgios, Andonopoulos, Andrew P.

“…Objective. To assess the efficacy of rituximab (RTX) in SSc. Methods. Fourteen patients with SSc were evaluated. Eight patients were randomized to receive two…”
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Adrenocorticotropic hormone: an effective “natural” biologic therapy for acute gout? by Daoussis, Dimitrios, Bogdanos, Dimitrios P., Dimitroulas, Theodoros, Sakkas, Lazaros, Andonopoulos, Andrew P.

“…Treatment of acute gout consists of non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and steroids. However, the typical patient with gout has…”
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B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis by Daoussis, Dimitrios, Tsamandas, Athanassios, Antonopoulos, Ioannis, Filippopoulou, Alexandra, Papachristou, Dionysios J, Papachristou, Nicholaos I, Andonopoulos, Andrew P, Liossis, Stamatis-Nick

“…Rituximab (RTX) may favorably affect skin and lung fibrosis in patients with systemic sclerosis (SSc); however, the underlying molecular mechanisms remain…”
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ACTH vs steroids for the treatment of acute gout in hospitalized patients: a randomized, open label, comparative study by Daoussis, Dimitrios, Kordas, Panagiotis, Varelas, George, Michalaki, Marina, Onoufriou, Anny, Mamali, Irene, Iliopoulos, George, Melissaropoulos, Konstantinos, Ntelis, Konstantinos, Velissaris, Dimitrios, Tzimas, Giannis, Georgiou, Panagiotis, Vamvakopoulou, Sofia, Paliogianni, Fotini, Andonopoulos, Andrew P., Georgopoulos, Neoklis

“…The management of acute gout in the hospital setting may be challenging since most patients are elderly with multiple unstable comorbidities. However, there…”
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Decreased Serotonin Levels and Serotonin‐Mediated Osteoblastic Inhibitory Signaling in Patients With Ankylosing Spondylitis by Klavdianou, Kalliopi, Liossis, Stamatis‐Nick, Papachristou, Dionysios J, Theocharis, Georgios, Sirinian, Chaido, Kottorou, Anastasia, Filippopoulou, Alexandra, Andonopoulos, Andrew P, Daoussis, Dimitrios

“…ABSTRACT Evidence suggests that serotonin is an inhibitor of bone formation. We aimed to assess: 1) serum serotonin levels in patients with ankylosing…”
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ACTH as first line treatment for acute gout in 181 hospitalized patients by Daoussis, Dimitrios, Antonopoulos, Ioannis, Yiannopoulos, Georgios, Andonopoulos, Andrew P

“…Abstract Objective We aimed at assessing the efficacy and safety of adrenocorticotropic hormone (ACTH) for the treatment of acute gout in hospitalized…”
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Clopidogrel treatment may associate with worsening of endothelial function and development of new digital ulcers in patients with systemic sclerosis: results from an open label, proof of concept study by Ntelis, Konstantinos, Gkizas, Vasileios, Filippopoulou, Alexandra, Davlouros, Periclis, Alexopoulos, Dimitrios, Andonopoulos, Andrew P, Daoussis, Dimitrios

“…Activated platelets release serotonin that binds 5-HT2B receptor on fibroblasts leading to fibroblast activation. Clopidogrel, an inhibitor of ADP-dependent…”
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A Case Report of Favourable Response of Polymyositis to Methotrexate Monotherapy by Daoussis, Dimitrios, Antonopoulos, Ioannis, Andonopoulos, Andrew P.

“…INTRODUCTION Steroids constitute either the main treatment for some rheumatic diseases such as temporal arteritis or may be used as a bridging therapy in…”
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B cell depletion treatment decreases CD4+IL4+ and CD4+CD40L+ T cells in patients with systemic sclerosis by Antonopoulos, Ioannis, Daoussis, Dimitrios, Lalioti, Maria-Eleni, Markatseli, Theodora E., Drosos, Alexandros A., Taraviras, Stavros, Andonopoulos, Andrew P., Liossis, Stamatis-Nick C.

“…Recent data suggests that rituximab may favorably affect skin fibrosis and lung function in patients with systemic sclerosis. Based on experimental data…”
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ACTH as first line treatment for acute calcium pyrophosphate crystal arthritis in 14 hospitalized patients by Daoussis, Dimitrios, Antonopoulos, Ioannis, Yiannopoulos, Georgios, Andonopoulos, Andrew P

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