Search Results - "Andjelkovic, Anuska"

Blood-brain barrier dysfunction and recovery after ischemic stroke by Jiang, Xiaoyan, Andjelkovic, Anuska V, Zhu, Ling, Yang, Tuo, Bennett, Michael V L, Chen, Jun, Keep, Richard F, Shi, Yejie

“…The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes and cells at the blood-brain interface and maintaining the…”
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Claudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke by Sladojevic, Nikola, Stamatovic, Svetlana M, Johnson, Allison M, Choi, Jennifer, Hu, Anna, Dithmer, Sophie, Blasig, Ingolf E, Keep, Richard F, Andjelkovic, Anuska V

“…Recent evidence suggests that blood-brain barrier (BBB) recovery and reestablishment of BBB impermeability after stroke is incomplete. This could influence…”
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Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins by Winkler, Lars, Blasig, Rosel, Breitkreuz-Korff, Olga, Berndt, Philipp, Dithmer, Sophie, Helms, Hans C, Puchkov, Dmytro, Devraj, Kavi, Kaya, Mehmet, Qin, Zhihai, Liebner, Stefan, Wolburg, Hartwig, Andjelkovic, Anuska V, Rex, Andre, Blasig, Ingolf E, Haseloff, Reiner F

“…The outcome of stroke is greatly influenced by the state of the blood–brain barrier (BBB). The BBB endothelium is sealed paracellularly by tight junction (TJ)…”
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Brain endothelial cell junctions after cerebral hemorrhage: Changes, mechanisms and therapeutic targets by Keep, Richard F, Andjelkovic, Anuska V, Xiang, Jianming, Stamatovic, Svetlana M, Antonetti, David A, Hua, Ya, Xi, Guohua

“…Vascular disruption is the underlying cause of cerebral hemorrhage, including intracerebral, subarachnoid and intraventricular hemorrhage. The disease etiology…”
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Critical role for the NLRP3 inflammasome during acute lung injury by Grailer, Jamison J, Canning, Bethany A, Kalbitz, Miriam, Haggadone, Mikel D, Dhond, Rasika M, Andjelkovic, Anuska V, Zetoune, Firas S, Ward, Peter A

“…The inflammasome is a key factor in innate immunity and senses soluble pathogen and danger-associated molecular patterns as well as biological crystals (urate,…”
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Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging by Stamatovic, Svetlana M., Martinez-Revollar, Gabriela, Hu, Anna, Choi, Jennifer, Keep, Richard F., Andjelkovic, Anuska V.

“…Accumulating evidence suggest that cerebral microvascular disease increases with advancing age and is associated with lacunar stroke, leukoaraiosis, vascular…”
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Blood-Brain Barrier Dysfunction in Normal Aging and Neurodegeneration: Mechanisms, Impact, and Treatments by Andjelkovic, Anuska V., Situ, Muyu, Citalan-Madrid, Ali Francisco, Stamatovic, Svetlana M., Xiang, Jianming, Keep, Richard F.

“…Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-functional interface, the blood-brain barrier (BBB). The…”
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Characterization of Blood–Brain Barrier Opening Induced by Transcranial Histotripsy in Murine Brains by Duclos, Sarah, Choi, Sang Won, Andjelkovic, Anuska V., Chaudhary, Neeraj, Camelo-Piragua, Sandra, Pandey, Aditya, Xu, Zhen

“…Transcranial histotripsy has shown promise as a non-invasive neurosurgical tool, as it has the ability to treat a wide range of locations in the brain without…”
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A novel approach to treatment of thromboembolic stroke in mice: Redirecting neutrophils toward a peripherally implanted CXCL1-soaked sponge by Stamatovic, Svetlana M., Phillips, Chelsea M., Keep, Richard F., Andjelkovic, Anuska V.

“…Neutrophils are considered key participants in post-ischemic stroke inflammation. They are the first white blood cells to arrive in ischemic brain and their…”
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Brain Endothelial Cell-Cell Junctions: How to "Open" the Blood Brain Barrier by Stamatovic, Svetlana M, Keep, Richard F, Andjelkovic, Anuska V

“…The blood-brain barrier (BBB) is a highly specialized structural and biochemical barrier that regulates the entry of blood-borne molecules into brain, and…”
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Systemic Delivery of an Adjuvant CXCR4–CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy by Alghamri, Mahmoud S., Banerjee, Kaushik, Mujeeb, Anzar A., Mauser, Ava, Taher, Ayman, Thalla, Rohit, McClellan, Brandon L., Varela, Maria L., Stamatovic, Svetlana M., Martinez-Revollar, Gabriela, Andjelkovic, Anuska V., Gregory, Jason V., Kadiyala, Padma, Calinescu, Alexandra, Jiménez, Jennifer A., Apfelbaum, April A., Lawlor, Elizabeth R., Carney, Stephen, Comba, Andrea, Faisal, Syed Mohd, Barissi, Marcus, Edwards, Marta B., Appelman, Henry, Sun, Yilun, Gan, Jingyao, Ackermann, Rose, Schwendeman, Anna, Candolfi, Marianela, Olin, Michael R., Lahann, Joerg, Lowenstein, Pedro R., Castro, Maria G.

“…Glioblastoma (GBM) is an aggressive primary brain cancer, with a 5 year survival of ∼5%. Challenges that hamper GBM therapeutic efficacy include (i) tumor…”
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Endocytosis of tight junction proteins and the regulation of degradation and recycling by Stamatovic, Svetlana M., Johnson, Allison M., Sladojevic, Nikola, Keep, Richard F., Andjelkovic, Anuska V.

“…Internalization of tight junction (TJ) proteins from the plasma membrane is a pivotal mechanism regulating TJ plasticity and function in both epithelial and…”
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Involvement of Epigenetic Mechanisms and Non-coding RNAs in Blood-Brain Barrier and Neurovascular Unit Injury and Recovery After Stroke by Stamatovic, Svetlana M, Phillips, Chelsea M, Martinez-Revollar, Gabriela, Keep, Richard F, Andjelkovic, Anuska V

“…Cessation of blood flow leads to a complex cascade of pathophysiological events at the blood-vascular-parenchymal interface which evolves over time and space,…”
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IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition by Kroenke, Mark A, Carlson, Thaddeus J, Andjelkovic, Anuska V, Segal, Benjamin M

“…The interleukin (IL)-12p40 family of cytokines plays a critical role in the development of experimental autoimmune encephalomyelitis (EAE). However, the…”
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Junctional proteins of the blood-brain barrier: New insights into function and dysfunction by Stamatovic, Svetlana M, Johnson, Allison M, Keep, Richard F, Andjelkovic, Anuska V

“…The blood-brain barrier (BBB) is a highly complex and dynamic barrier. It is formed by an interdependent network of brain capillary endothelial cells, endowed…”
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Modeling blood-brain barrier pathology in cerebrovascular disease in vitro: current and future paradigms by Andjelkovic, Anuska V, Stamatovic, Svetlana M, Phillips, Chelsea M, Martinez-Revollar, Gabriela, Keep, Richard F

“…The complexity of the blood-brain barrier (BBB) and neurovascular unit (NVU) was and still is a challenge to bridge. A highly selective, restrictive and…”
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Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure by Johnson, Allison M., Roach, James P., Hu, Anna, Stamatovic, Svetlana M., Zochowski, Michal R., Keep, Richard F., Andjelkovic, Anuska V.

“…Familial cerebral cavernous malformations type III (fCCM3) is a disease of the cerebrovascular system caused by loss‐of‐function mutations in ccm3 that result…”
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Vascular disruption and blood-brain barrier dysfunction in intracerebral hemorrhage by Keep, Richard F, Zhou, Ningna, Xiang, Jianming, Andjelkovic, Anuska V, Hua, Ya, Xi, Guohua

“…This article reviews current knowledge of the mechanisms underlying the initial hemorrhage and secondary blood-brain barrier (BBB) dysfunction in primary…”
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Endothelial Targets in Stroke: Translating Animal Models to Human by Andjelkovic, Anuska V, Xiang, Jianming, Stamatovic, Svetlana M, Hua, Ya, Xi, Guohua, Wang, Michael M, Keep, Richard F

“…Cerebral ischemia (stroke) induces injury to the cerebral endothelium that may contribute to parenchymal injury and worsen outcome. This review focuses on…”
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A tissue chip with integrated digital immunosensors: In situ brain endothelial barrier cytokine secretion monitoring by Su, Shiuan-Haur, Song, Yujing, Stephens, Andrew, Situ, Muyu, McCloskey, Molly C., McGrath, James L., Andjelkovic, Anuska V., Singer, Benjamin H., Kurabayashi, Katsuo

“…Organ-on-a-chip platforms have potential to offer more cost-effective, ethical, and human-resembling models than animal models for disease study and drug…”
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