Search Results - "Andhey, Prabhakar Sairam"

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging by Mogilenko, Denis A., Shpynov, Oleg, Andhey, Prabhakar Sairam, Arthur, Laura, Swain, Amanda, Esaulova, Ekaterina, Brioschi, Simone, Shchukina, Irina, Kerndl, Martina, Bambouskova, Monika, Yao, Zhangting, Laha, Anwesha, Zaitsev, Konstantin, Burdess, Samantha, Gillfilan, Susan, Stewart, Sheila A., Colonna, Marco, Artyomov, Maxim N.

“…Systematic understanding of immune aging on a whole-body scale is currently lacking. We characterized age-associated alterations in immune cells across…”
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Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia by Wang, Chao, Xiong, Monica, Gratuze, Maud, Bao, Xin, Shi, Yang, Andhey, Prabhakar Sairam, Manis, Melissa, Schroeder, Caitlin, Yin, Zhuoran, Madore, Charlotte, Butovsky, Oleg, Artyomov, Maxim, Ulrich, Jason D., Holtzman, David M.

“…The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease and directly influences tauopathy and tau-mediated…”
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Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms by Shi, Yang, Andhey, Prabhakar Sairam, Ising, Christina, Wang, Kairuo, Snipes, Lisa L., Boyer, Kevin, Lawson, Stephanie, Yamada, Kaoru, Qin, Wei, Manis, Melissa, Serrano, Javier Remolina, Benitez, Bruno A., Schmidt, Robert E., Artyomov, Maxim, Ulrich, Jason D., Holtzman, David M.

“…APOE is the strongest genetic risk factor for late-onset Alzheimer’s disease. ApoE exacerbates tau-associated neurodegeneration by driving microglial…”
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Altered ratio of dendritic cell subsets in skin-draining lymph nodes promotes Th2-driven contact hypersensitivity by Miller, Hannah L., Andhey, Prabhakar Sairam, Swiecki, Melissa K., Rosa, Bruce A., Zaitsev, Konstantin, Villani, Alexandra-Chloe, Mitreva, Makedonka, Artyomov, Maxim N., Gilfillan, Susan, Cella, Marina, Colonna, Marco

“…Plasmacytoid dendritic cells (pDCs) specialize in the production of type I IFN (IFN-I). pDCs can be depleted in vivo by injecting diphtheria toxin (DT) in a…”
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Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages by Swain, Amanda, Bambouskova, Monika, Kim, Hyeryun, Andhey, Prabhakar Sairam, Duncan, Dustin, Auclair, Karine, Chubukov, Victor, Simons, Donald M., Roddy, Thomas P., Stewart, Kelly M., Artyomov, Maxim N.

“…Following activation, macrophages undergo extensive metabolic rewiring 1 , 2 . Production of itaconate through the inducible enzyme IRG1 is a key hallmark of…”
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B cells in the mesenteric fat contribute to Crohn’s disease by Erlich, Emma, Czepielewski, Rafael Sanguinetti, Kumar, Shashi, Andhey, Prabhakar Sairam, Artyomov, Maxim N., Ellebedy, Ali H., Randolph, Gwendalyn J

“…Abstract Crohn’s disease [CD] is one of the two common forms of inflammatory bowel disease and it affects over half a million Americans. Like many other…”
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IL-15 priming alters the regulation of IFN-γ production in NK cells by Cimpean, Maria, Keppel, Molly P., Gainullina, Anastasiia, Swain, Amanda, Andhey, Prabhakar Sairam, He, Diana, Young, Howard A., Artyomov, Maxim N., Cooper, Megan A.

“…Abstract Natural killer (NK) cells are innate lymphocytes important for the control of infections and tumors. Their effector functions can be triggered by…”
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EP300 IS ASSOCIATED WITH ALTERED BILE ACIDS IN ALZHEIMER’S DISEASE by Andhey, Sairam Prabhakar, Nho, Kwangsik, Risacher, Shannon L., Arnold, Matthias, Mahmoudian Dehkordi, Siamak, Kaddurah-Daouk, Rima F., Saykin, Andrew J., Yan, Jingwen

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P2‐253: EP300 IS ASSOCIATED WITH ALTERED BILE ACIDS IN ALZHEIMER'S DISEASE by Andhey, Sairam Prabhakar, Nho, Kwangsik, Risacher, Shannon L., Arnold, Matthias, Mahmoudian Dehkordi, Siamak, Kaddurah-Daouk, Rima F., Saykin, Andrew J., Yan, Jingwen

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