Search Results - "Andexer, Jennifer"

Emerging Enzymes for ATP Regeneration in Biocatalytic Processes by Andexer, Jennifer N., Richter, Michael

“…Adenosine‐5′‐triphosphate‐dependent enzyme catalysed reactions are widespread in nature. Consequently, the enzymes involved have an intrinsic potential for use…”
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Catalytic Alkylation Using a Cyclic S‐Adenosylmethionine Regeneration System by Mordhorst, Silja, Siegrist, Jutta, Müller, Michael, Richter, Michael, Andexer, Jennifer N.

“…S‐Adenosylmethionine‐dependent methyltransferases are versatile tools for the specific alkylation of many compounds, such as pharmaceuticals, but their…”
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Challenging nature’s preference for methylation by Andexer, Jennifer N., Rentmeister, Andrea

“…Enzymes that methylate using S -adenosyl- l -methionine — nature’s methyliodide — are abundant and often promiscuous; however, a preference for alkylation over…”
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Doping In Vivo Alkylation in E. coli by Introducing the Direct Sulfurylation Pathway of S. cerevisiae by Mohr, Michael K F, Benčić, Patricia, Andexer, Jennifer N

“…Methylation and alkylation are important techniques used for the synthesis and derivatisation of small molecules and natural products. Application of…”
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Co-factor demand and regeneration in the enzymatic one-step reduction of carboxylates to aldehydes in cell-free systems by Strohmeier, Gernot A., Schwarz, Anna, Andexer, Jennifer N., Winkler, Margit

“…•Polyphosphate (polyP) sources differ significantly in their capability to provide reactive phosphate groups for the polyphosphate kinase-based ATP…”
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A Cobalamin‐Dependent Radical SAM Enzyme Catalyzes the Unique Cα‐Methylation of Glutamine in Methyl‐Coenzyme M Reductase by Gagsteiger, Jana, Jahn, Sören, Heidinger, Lorenz, Gericke, Lukas, Andexer, Jennifer N., Friedrich, Thorsten, Loenarz, Christoph, Layer, Gunhild

“…Methyl‐coenzyme M reductase, which is responsible for the production of the greenhouse gas methane during biological methane formation, carries several unique…”
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Make or break: the thermodynamic equilibrium of polyphosphate kinase-catalysed reactions by Keppler, Michael, Moser, Sandra, Jessen, Henning J, Held, Christoph, Andexer, Jennifer N

“…Polyphosphate kinases (PPKs) have become popular biocatalysts for nucleotide 5'-triphosphate (NTP) synthesis and regeneration. Two unrelated families are…”
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Functional and structural characterisation of a bacterial O‐methyltransferase and factors determining regioselectivity by Siegrist, Jutta, Netzer, Julia, Mordhorst, Silja, Karst, Lukas, Gerhardt, Stefan, Einsle, Oliver, Richter, Michael, Andexer, Jennifer N.

“…Mg2+‐dependent catechol‐O‐methyltransferases occur in animals as well as in bacteria, fungi and plants, often with a pronounced selectivity towards one of the…”
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Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures by Parnell, Alice E., Mordhorst, Silja, Kemper, Florian, Giurrandino, Mariacarmela, Prince, Josh P., Schwarzer, Nikola J., Hofer, Alexandre, Wohlwend, Daniel, Jessen, Henning J., Gerhardt, Stefan, Einsle, Oliver, Oyston, Petra C. F., Andexer, Jennifer N., Roach, Peter L.

“…Inorganic polyphosphate is a ubiquitous, linear biopolymer built of up to thousands of phosphate residues that are linked by energy-rich phosphoanhydride…”
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Non-Canonical Nucleosides: Biomimetic Triphosphorylation, Incorporation into mRNA and Effects on Translation and Structure by Benčić, Patricia, Keppler, Michael, Kuge, Marco, Qiu, Danye, Schütte, Lena M, Häner, Markus, Strack, Katharina, Jessen, Henning J, Andexer, Jennifer N, Loenarz, Christoph

“…Recent advances in mRNA therapeutics demand efficient toolkits for the incorporation of nucleoside analogues into mRNA suitable for downstream applications…”
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Methyltransferases: Functions and Applications by Abdelraheem, Eman, Thair, Benjamin, Varela, Romina Fernández, Jockmann, Emely, Popadić, Désirée, Hailes, Helen C., Ward, John M., Iribarren, Adolfo M., Lewkowicz, Elizabeth S., Andexer, Jennifer N., Hagedoorn, Peter‐Leon, Hanefeld, Ulf

“…In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent methyltransferases and SAM are evaluated. Their structural classification…”
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A Flexible Polyphosphate-Driven Regeneration System for CoenzymeA Dependent Catalysis by Mordhorst, Silja, Maurer, Alice, Popadic, Désirée, Brech, Johanna, Andexer, Jennifer N

“…CoenzymeA (CoA) is a common cofactor in biochemical reactions, and CoA-dependent enzymes catalyze essential steps in anabolism and catabolism. This complex…”
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A Flexible Polyphosphate‐Driven Regeneration System for Coenzyme A Dependent Catalysis by Mordhorst, Silja, Maurer, Alice, Popadić, Désirée, Brech, Johanna, Andexer, Jennifer N

“…Coenzyme A (CoA) is a common cofactor in biochemical reactions, and CoA‐dependent enzymes catalyze essential steps in anabolism and catabolism. This complex…”
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Multienzyme One‐Pot Cascades Incorporating Methyltransferases for the Strategic Diversification of Tetrahydroisoquinoline Alkaloids by Subrizi, Fabiana, Wang, Yu, Thair, Benjamin, Méndez‐Sánchez, Daniel, Roddan, Rebecca, Cárdenas‐Fernández, Max, Siegrist, Jutta, Richter, Michael, Andexer, Jennifer N., Ward, John M., Hailes, Helen C.

“…The tetrahydroisoquinoline (THIQ) ring system is present in a large variety of structurally diverse natural products exhibiting a wide range of biological…”
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Enzymatic Synthesis of l‐Methionine Analogues and Application in a Methyltransferase Catalysed Alkylation Cascade by Mohr, Michael K. F., Saleem‐Batcha, Raspudin, Cornelissen, Nicolas V., Andexer, Jennifer N.

“…Chemical modification of small molecules is a key step for the development of pharmaceuticals. S‐adenosyl‐l‐methionine (SAM) analogues are used by…”
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A Multi-Enzyme Cascade Reaction for the Production of 2′3′-cGAMP by Becker, Martin, Nikel, Patrick, Andexer, Jennifer N., Lütz, Stephan, Rosenthal, Katrin

“…Multi-enzyme cascade reactions for the synthesis of complex products have gained importance in recent decades. Their advantages compared to single…”
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Asymmetric C‐Alkylation by the S‐Adenosylmethionine‐Dependent Methyltransferase SgvM by Sommer‐Kamann, Christina, Fries, Alexander, Mordhorst, Silja, Andexer, Jennifer N., Müller, Michael

“…S‐Adenosylmethionine‐dependent methyltransferases (MTs) play a decisive role in the biosynthesis of natural products and in epigenetic processes. MTs catalyze…”
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Structures and Protein Engineering of the α‐Keto Acid C‐Methyltransferases SgvM and MrsA for Rational Substrate Transfer by Sommer‐Kamann, Christina, Breiltgens, Juliane, Zou, Ziruo, Gerhardt, Stefan, Saleem‐Batcha, Raspudin, Kemper, Florian, Einsle, Oliver, Andexer, Jennifer N., Müller, Michael

“…S‐adenosyl‐l‐methionine‐dependent methyltransferases (MTs) are involved in the C‐methylation of a variety of natural products. The MTs SgvM from Streptomyces…”
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A Multi-Enzyme Cascade Reaction for the Production of 2'3'-cGAMP by Becker, Martin, Nikel, Patrick, Andexer, Jennifer N, Lütz, Stephan, Rosenthal, Katrin

“…Multi-enzyme cascade reactions for the synthesis of complex products have gained importance in recent decades. Their advantages compared to single…”
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Biosynthesis of Menaquinone in E. coli: Identification of an Elusive Isomer of SEPHCHC by Fries, Alexander, Mazzaferro, Laura S., Bisel, Philippe, Hubrich, Florian, Andexer, Jennifer N., Müller, Michael

“…In the biosynthesis of menaquinone in bacteria, the thiamine diphosphate‐dependent enzyme MenD catalyzes the decarboxylative carboligation of α‐ketoglutarate…”
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