Search Results - "Anderton, Stephen"

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity by Serrels, Alan, Lund, Tom, Serrels, Bryan, Byron, Adam, McPherson, Rhoanne C., von Kriegsheim, Alexander, Gómez-Cuadrado, Laura, Canel, Marta, Muir, Morwenna, Ring, Jennifer E., Maniati, Eleni, Sims, Andrew H., Pachter, Jonathan A., Brunton, Valerie G., Gilbert, Nick, Anderton, Stephen M., Nibbs, Robert J.B., Frame, Margaret C.

“…Focal adhesion kinase (FAK) promotes anti-tumor immune evasion. Specifically, the kinase activity of nuclear-targeted FAK in squamous cell carcinoma (SCC)…”
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Not always the bad guys: B cells as regulators of autoimmune pathology by Anderton, Stephen M, Gray, David, Fillatreau, Simon

“…Accumulating evidence suggests that B cells can regulate immune responses. Here, the authors present a model to explain how B cells may regulate autoimmune…”
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The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY by Harding, Simon D, Sharman, Joanna L, Faccenda, Elena, Southan, Chris, Pawson, Adam J, Ireland, Sam, Gray, Alasdair J G, Bruce, Liam, Alexander, Stephen P H, Anderton, Stephen, Bryant, Clare, Davenport, Anthony P, Doerig, Christian, Fabbro, Doriano, Levi-Schaffer, Francesca, Spedding, Michael, Davies, Jamie A

“…Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions…”
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B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells by Barr, Tom A, Shen, Ping, Brown, Sheila, Lampropoulou, Vicky, Roch, Toralf, Lawrie, Sarah, Fan, Boli, O'Connor, Richard A, Anderton, Stephen M, Bar-Or, Amit, Fillatreau, Simon, Gray, David

“…B cells have paradoxical roles in autoimmunity, exerting both pathogenic and protective effects. Pathogenesis may be antibody independent, as B cell depletion…”
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Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity by Kieback, Elisa, Hilgenberg, Ellen, Stervbo, Ulrik, Lampropoulou, Vicky, Shen, Ping, Bunse, Mario, Jaimes, Yarua, Boudinot, Pierre, Radbruch, Andreas, Klemm, Uwe, Kühl, Anja A., Liblau, Roland, Hoevelmeyer, Nadine, Anderton, Stephen M., Uckert, Wolfgang, Fillatreau, Simon

“…Regulatory T (Treg) cells expressing Foxp3 transcripton factor are essential for immune homeostasis. They arise in the thymus as a separate lineage from…”
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Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems by Nestor, Colm E, Ottaviano, Raffaele, Reinhardt, Diana, Cruickshanks, Hazel A, Mjoseng, Heidi K, McPherson, Rhoanne C, Lentini, Antonio, Thomson, John P, Dunican, Donncha S, Pennings, Sari, Anderton, Stephen M, Benson, Mikael, Meehan, Richard R

“…The DNA methylation profiles of mammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting increasing divergence…”
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IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases by Shen, Ping, Roch, Toralf, Lampropoulou, Vicky, O’Connor, Richard A., Stervbo, Ulrik, Hilgenberg, Ellen, Ries, Stefanie, Dang, Van Duc, Jaimes, Yarúa, Daridon, Capucine, Li, Rui, Jouneau, Luc, Boudinot, Pierre, Wilantri, Siska, Sakwa, Imme, Miyazaki, Yusei, Leech, Melanie D., McPherson, Rhoanne C., Wirtz, Stefan, Neurath, Markus, Hoehlig, Kai, Meinl, Edgar, Grützkau, Andreas, Grün, Joachim R., Horn, Katharina, Kühl, Anja A., Dörner, Thomas, Bar-Or, Amit, Kaufmann, Stefan H. E., Anderton, Stephen M., Fillatreau, Simon

“…B cells can secrete IL-35 upon activation, and subsequently contribute negatively to the regulation of immunity, such as T-cell-mediated autoimmunity or…”
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Antigen receptor‐engineered Tregs inhibit CNS autoimmunity in cell therapy using nonredundant immune mechanisms in mice by Pohar, Jelka, O'Connor, Richard, Manfroi, Benoît, El‐Behi, Mohamed, Jouneau, Luc, Boudinot, Pierre, Bunse, Mario, Uckert, Wolfgang, Luka, Marine, Ménager, Mickael, Liblau, Roland, Anderton, Stephen M., Fillatreau, Simon

“…CD4+FOXP3+ Tregs are currently explored to develop cell therapies against immune‐mediated disorders, with an increasing focus on antigen receptor‐engineered…”
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A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells by Johnston, Chris J. C., Smyth, Danielle J., Kodali, Ravindra B., White, Madeleine P. J., Harcus, Yvonne, Filbey, Kara J., Hewitson, James P., Hinck, Cynthia S., Ivens, Alasdair, Kemter, Andrea M., Kildemoes, Anna O., Le Bihan, Thierry, Soares, Dinesh C., Anderton, Stephen M., Brenn, Thomas, Wigmore, Stephen J., Woodcock, Hannah V., Chambers, Rachel C., Hinck, Andrew P., McSorley, Henry J., Maizels, Rick M.

“…Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells…”
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The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury by Campana, Lara, Starkey Lewis, Philip J, Pellicoro, Antonella, Aucott, Rebecca L, Man, Janet, O'Duibhir, Eoghan, Mok, Sarah E, Ferreira-Gonzalez, Sofia, Livingstone, Eilidh, Greenhalgh, Stephen N, Hull, Katherine L, Kendall, Timothy J, Vernimmen, Douglas, Henderson, Neil C, Boulter, Luke, Gregory, Christopher D, Feng, Yi, Anderton, Stephen M, Forbes, Stuart J, Iredale, John P

“…The disposal of apoptotic bodies by professional phagocytes is crucial to effective inflammation resolution. Our ability to improve the disposal of apoptotic…”
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Curing CNS autoimmune disease with myelin-reactive Foxp3⁺ Treg by Stephens, Leigh A, Malpass, Katy H, Anderton, Stephen M

“…The potential use of CD4⁺Foxp3⁺ Treg as a cellular therapy for autoimmune disease is of great interest. For clinical translation, the key objective is to…”
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Natural Recovery and Protection from Autoimmune Encephalomyelitis: Contribution of CD4+CD25+ Regulatory Cells within the Central Nervous System by McGeachy, Mandy J, Stephens, Leigh A, Anderton, Stephen M

“…Immune regulation of autoimmune disease can function at two sites: at the secondary lymphoid organs or in the target organ itself. In this study, we…”
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Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis by Duffin, Rodger, O'Connor, Richard A., Crittenden, Siobhan, Forster, Thorsten, Yu, Cunjing, Zheng, Xiaozhong, Smyth, Danielle, Robb, Calum T., Rossi, Fiona, Skouras, Christos, Tang, Shaohui, Richards, James, Pellicoro, Antonella, Weller, Richard B., Breyer, Richard M., Mole, Damian J., Iredale, John P., Anderton, Stephen M., Narumiya, Shuh, Maizels, Rick M., Ghazal, Peter, Howie, Sarah E., Rossi, Adriano G., Yao, Chengcan

“…Systemic inflammation, which results from the massive release of proinflammatory molecules into the circulatory system, is a major risk factor for severe…”
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CD11c depletion severely disrupts Th2 induction and development in vivo by Phythian-Adams, Alexander T, Cook, Peter C, Lundie, Rachel J, Jones, Lucy H, Smith, Katherine A, Barr, Tom A, Hochweller, Kristin, Anderton, Stephen M, Hämmerling, Günter J, Maizels, Rick M, MacDonald, Andrew S

“…Although dendritic cells (DCs) are adept initiators of CD4(+) T cell responses, their fundamental importance in this regard in Th2 settings remains to be…”
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Cutting Edge: Th1 Cells Facilitate the Entry of Th17 Cells to the Central Nervous System during Experimental Autoimmune Encephalomyelitis by O'Connor, Richard A, Prendergast, Catriona T, Sabatos, Catherine A, Lau, Clement W. Z, Leech, Melanie D, Wraith, David C, Anderton, Stephen M

“…It has recently been proposed that experimental autoimmune encephalomyelitis, once considered the classical Th1 disease, is predominantly Th17 driven. In this…”
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Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease by O'Connor, Richard A, Anderton, Stephen M

“…Abstract The role of T regulatory (Treg) cells expressing the forkhead box transcription factor 3 (foxp3) in the control of autoaggressive immune responses is…”
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Activated T cells recruit exosomes secreted by dendritic cells via LFA-1 by Nolte-‘t Hoen, Esther N.M., Buschow, Sonja I., Anderton, Stephen M., Stoorvogel, Willem, Wauben, Marca H.M.

“…Dendritic cells (DCs) are known to secrete exosomes that transfer membrane proteins, like major histocompatibility complex class II, to other DCs…”
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IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks by Serrels, Bryan, McGivern, Niamh, Canel, Marta, Byron, Adam, Johnson, Sarah C, McSorley, Henry J, Quinn, Niall, Taggart, David, Von Kreigsheim, Alex, Anderton, Stephen M, Serrels, Alan, Frame, Margaret C

“…Focal adhesion kinase (FAK) mediates tumor cell-intrinsic behaviors that promote tumor growth and metastasis. We previously showed that FAK also induces the…”
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T‐bet is essential for Th1‐mediated, but not Th17‐mediated, CNS autoimmune disease by O'Connor, Richard A., Cambrook, Helen, Huettner, Katja, Anderton, Stephen M.

“…T cells that produce both IL‐17 and IFN‐γ, and co‐express ROR‐γt and T‐bet, are often found at sites of autoimmune inflammation. However, it is unknown whether…”
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TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity by Lampropoulou, Vicky, Hoehlig, Kai, Roch, Toralf, Neves, Patricia, Gomez, Elisabeth Calderon, Sweenie, Claire H, Hao, Yi, Freitas, Antonio A, Steinhoff, Ulrich, Anderton, Stephen M, Fillatreau, Simon

“…TLR sense microbial infections, and control activation of immune responses. Dendritic cells, macrophages, and B lymphocytes express TLR and the TLR-signaling…”
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