Search Results - "Anderson, Timothy J. C."

A Major Genome Region Underlying Artemisinin Resistance in Malaria by Cheeseman, Ian H., Miller, Becky A., Nair, Shalini, Nkhoma, Standwell, Tan, Asako, Tan, John C., Saai, Salma Al, Phyo, Aung Pyae, Moo, Carit Ler, Lwin, Khin Maung, McGready, Rose, Ashley, Elizabeth, Imwong, Mallika, Stepniewska, Kasia, Yi, Poravuth, Dondorp, Arjen M., Mayxay, Mayfong, Newton, Paul N., White, Nicholas J., Nosten, François, Ferdig, Michael T., Anderson, Timothy J. C.

“…Evolving resistance to arte misi ni n-based compounds threatens to derail attempts to control malaria. Resistance has been confirmed in western Cambodia and…”
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Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance by Cerqueira, Gustavo C, Cheeseman, Ian H, Schaffner, Steve F, Nair, Shalini, McDew-White, Marina, Phyo, Aung Pyae, Ashley, Elizabeth A, Melnikov, Alexandre, Rogov, Peter, Birren, Bruce W, Nosten, François, Anderson, Timothy J C, Neafsey, Daniel E

“…Artemisinin-based combination therapies are the first line of treatment for Plasmodium falciparum infections worldwide, but artemisinin resistance has risen…”
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Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent by Taylor, Aimee R, Schaffner, Stephen F, Cerqueira, Gustavo C, Nkhoma, Standwell C, Anderson, Timothy J C, Sriprawat, Kanlaya, Pyae Phyo, Aung, Nosten, François, Neafsey, Daniel E, Buckee, Caroline O

“…With the rapidly increasing abundance and accessibility of genomic data, there is a growing interest in using population genetic approaches to characterize…”
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Identity-by-descent with uncertainty characterises connectivity of Plasmodium falciparum populations on the Colombian-Pacific coast by Taylor, Aimee R, Echeverry, Diego F, Anderson, Timothy J C, Neafsey, Daniel E, Buckee, Caroline O

“…Characterising connectivity between geographically separated biological populations is a common goal in many fields. Recent approaches to understanding…”
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Contribution of parasite and host genotype to immunopathology of schistosome infections by Jutzeler, Kathrin S, Le Clec'h, Winka, Chevalier, Frédéric D, Anderson, Timothy J C

“…The role of pathogen genotype in determining disease severity and immunopathology has been studied intensively in microbial pathogens including bacteria,…”
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Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis by Carrasquilla, Manuela, Early, Angela M, Taylor, Aimee R, Knudson Ospina, Angélica, Echeverry, Diego F, Anderson, Timothy J C, Mancilla, Elvira, Aponte, Samanda, Cárdenas, Pablo, Buckee, Caroline O, Rayner, Julian C, Sáenz, Fabián E, Neafsey, Daniel E, Corredor, Vladimir

“…The human malaria parasite Plasmodium falciparum is globally widespread, but its prevalence varies significantly between and even within countries. Most…”
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Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment by Chevalier, Frédéric D, Le Clec'h, Winka, McDew-White, Marina, Menon, Vinay, Guzman, Meghan A, Holloway, Stephen P, Cao, Xiaohang, Taylor, Alexander B, Kinung'hi, Safari, Gouvras, Anouk N, Webster, Bonnie L, Webster, Joanne P, Emery, Aidan M, Rollinson, David, Garba Djirmay, Amadou, Al Mashikhi, Khalid M, Al Yafae, Salem, Idris, Mohamed A, Moné, Hélène, Mouahid, Gabriel, Hart, P John, LoVerde, Philip T, Anderson, Timothy J C

“…Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to…”
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No evidence for schistosome parasite fitness trade-offs in the intermediate and definitive host by Le Clec'h, Winka, Chevalier, Frédéric D, Jutzeler, Kathrin, Anderson, Timothy J C

“…The trematode parasite Schistosoma mansoni uses an aquatic snail intermediate and a vertebrate definitive host to complete its life cycle. We previously showed…”
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Genetic and Molecular Basis of Drug Resistance and Species-Specific Drug Action in Schistosome Parasites by Valentim, Claudia L. L., Cioli, Donato, Chevalier, Frédéric D., Cao, Xiaohang, Taylor, Alexander B., Holloway, Stephen P., Pica-Mattoccia, Livia, Guidi, Alessandra, Basso, Annalisa, Tsai, Isheng J., Berriman, Matthew, Carvalho-Queiroz, Claudia, Almeida, Marcio, Aguilar, Hector, Frantz, Doug E., Hart, P. John, LoVerde, Philip T., Anderson, Timothy J. C.

“…Oxamniquine resistance evolved in the human blood fluke (Schistosoma monsoni) in Brazil in the 1970s. We crossed parental parasites differing -500-fold in drug…”
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Pairwise growth competitions identify relative fitness relationships among artemisinin resistant Plasmodium falciparum field isolates by Tirrell, Abigail R, Vendrely, Katelyn M, Checkley, Lisa A, Davis, Sage Z, McDew-White, Marina, Cheeseman, Ian H, Vaughan, Ashley M, Nosten, François H, Anderson, Timothy J C, Ferdig, Michael T

“…Competitive outcomes between co-infecting malaria parasite lines can reveal fitness disparities in blood stage growth. Blood stage fitness costs often…”
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The extended recovery ring-stage survival assay provides a superior association with patient clearance half-life and increases throughput by Davis, Sage Z, Singh, Puspendra P, Vendrely, Katelyn M, Shoue, Douglas A, Checkley, Lisa A, McDew-White, Marina, Button-Simons, Katrina A, Cassady, Zione, Sievert, Mackenzie A C, Foster, Gabriel J, Nosten, François H, Anderson, Timothy J C, Ferdig, Michael T

“…Tracking and understanding artemisinin resistance is key for preventing global setbacks in malaria eradication efforts. The ring-stage survival assay (RSA) is…”
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Striking differences in virulence, transmission and sporocyst growth dynamics between two schistosome populations by Le Clecʼh, Winka, Diaz, Robbie, Chevalier, Frédéric D, McDew-White, Marina, Anderson, Timothy J C

“…Parasite traits associated with transmission success, such as the number of infective stages released from the host, are expected to be optimized by natural…”
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Gene Amplification of the Multidrug Resistance 1 Gene of Plasmodium vivax Isolates from Thailand, Laos, and Myanmar by IMWONG, Mallika, PUKRITTAYAKAMEE, Sasithon, WHITE, Nicholas J, PONGTAVORNPINYO, Wirichada, NAKEESATHIT, Supatchara, NAIR, Shalini, NEWTON, Paul, NOSTEN, Francois, ANDERSON, Timothy J. C, DONDORP, Arjen, DAY, Nicholas P. J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Are Transporter Genes Other than the Chloroquine Resistance Locus (pfcrt) and Multidrug Resistance Gene (pfmdr) Associated with Antimalarial Drug Resistance? by ANDERSON, Timothy J. C, NAIR, Shalini, HUANG QIN, SINGLAM, Sittaporn, BROCKMAN, Alan, PAIPHUN, Lucy, NOSTEN, Francois

“…ERRATUM ( vol. 49 , p. 3990 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg…”
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Efficient linkage mapping using exome capture and extreme QTL in schistosome parasites by Chevalier, Frédéric D, Valentim, Claudia L L, LoVerde, Philip T, Anderson, Timothy J C

“…Identification of parasite genes that underlie traits such as drug resistance and host specificity is challenging using classical linkage mapping approaches…”
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Genomic linkage map of the human blood fluke Schistosoma mansoni by Criscione, Charles D, Valentim, Claudia L L, Hirai, Hirohisa, LoVerde, Philip T, Anderson, Timothy J C

“…Schistosoma mansoni is a blood fluke that infects approximately 90 million people. The complete life cycle of this parasite can be maintained in the…”
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Susceptibility of BS90 Biomphalaria glabrata snails to infection by SmLE Schistosoma mansoni segregates as a dominant allele in a cluster of polymorphic genes for single-pass transmembrane proteins by Blouin, Michael S, Bollmann, Stephanie R, Le Clec'h, Winka, Chevalier, Frédéric D, Anderson, Timothy J C, Tennessen, Jacob A

“…The trematodes that cause schistosomiasis in humans require aquatic snails as intermediate hosts. Identifying the genes in snails at which allelic variation…”
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Schistosoma mansoni by Anderson, Timothy J.C., Enabulele, Egie E.

“…Schistosoma mansoni is the causative agent of intestinal schistosomiasis and infects ~54 million people annually, causing significant mortality and morbidity…”
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Prospecting for Zoonotic Pathogens by Using Targeted DNA Enrichment by Enabulele, Egie E, Le Clec'h, Winka, Roberts, Emma K, Thompson, Cody W, McDonough, Molly M, Ferguson, Adam W, Bradley, Robert D, Anderson, Timothy J C, Platt, 2nd, Roy N

“…More than 60 zoonoses are linked to small mammals, including some of the most devastating pathogens in human history. Millions of museum-archived tissues are…”
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Landscape genetics reveals focal transmission of a human macroparasite by Criscione, Charles D, Anderson, Joel D, Sudimack, Dan, Subedi, Janardan, Upadhayay, Ram P, Jha, Bharat, Williams, Kimberly D, Williams-Blangero, Sarah, Anderson, Timothy J C

“…Macroparasite infections (e.g., helminths) remain a major human health concern. However, assessing transmission dynamics is problematic because the direct…”
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