Search Results - "Anderson, Richard W"

Lipid rafts: at a crossroad between cell biology and physics by Jacobson, Ken, Mouritsen, Ole G, Anderson, Richard G. W

“…Membrane lateral heterogeneity is accepted as a requirement for the function of biological membranes and the notion of lipid rafts gives specificity to this…”
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role for lipid droplets in inter-membrane lipid traffic by Zehmer, John K, Huang, Youguo, Peng, Gong, Pu, Jing, Anderson, Richard G.W, Liu, Pingsheng

“…All cells have the capacity to accumulate neutral lipids and package them into lipid droplets. Recent proteomic analyses indicate that lipid droplets are not…”
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lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology by Szymanski, Kimberly M, Binns, Derk, Bartz, René, Grishin, Nick V, Li, Wei-Ping, Agarwal, Anil K, Garg, Abhimanyu, Anderson, Richard G.W, Goodman, Joel M

“…Lipodystrophy is a disorder characterized by a loss of adipose tissue often accompanied by severe hypertriglyceridemia, insulin resistance, diabetes, and fatty…”
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LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis by Boucher, Philippe, Gotthardt, Michael, Li, Wei-Ping, Richard G. W. Anderson, Herz, Joachim

“…Vascular smooth muscle cell (SMC) proliferation and migration are important events in the development of atherosclerosis. The low-density lipoprotein…”
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Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization by del Pozo, Miguel A, Balasubramanian, Nagaraj, Alderson, Nazilla B, Kiosses, William B, Grande-García, Araceli, Anderson, Richard G. W, Schwartz, Martin A

“…Growth of normal cells is anchorage dependent because signalling through multiple pathways including Erk, phosphatidylinositol-3-OH kinase (PI(3)K) and Rac…”
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THE CAVEOLAE MEMBRANE SYSTEM by Anderson, Richard G. W

“…The cell biology of caveolae is a rapidly growing area of biomedical research. Caveolae are known primarily for their ability to transport molecules across…”
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Integrins Regulate Rac Targeting by Internalization of Membrane Domains by del Pozo, Miguel A., Alderson, Nazilla B., Kiosses, William B., Chiang, Hui-Hsien, Richard G. W. Anderson, Schwartz, Martin A.

“…Translocation of the small GTP-binding protein Rac1 to the cell plasma membrane is essential for activating downstream effectors and requires integrin-mediated…”
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OSBP Is a Cholesterol-Regulated Scaffolding Protein in Control of ERK1/2 Activation by Wang, Ping-yuan, Weng, Jian, Richard G. W. Anderson

“…Oxysterol-binding protein (OSBP) is the founding member of a family of sterol-binding proteins implicated in vesicle transport, lipid metabolism, and signal…”
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intimate collaboration between peroxisomes and lipid bodies by Binns, Derk, Januszewski, Tom, Chen, Yue, Hill, Justin, Markin, Vladislav S, Zhao, Yingming, Gilpin, Christopher, Chapman, Kent D, Anderson, Richard G.W, Goodman, Joel M

“…Although peroxisomes oxidize lipids, the metabolism of lipid bodies and peroxisomes is thought to be largely uncoupled from one another. In this study, using…”
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Disruption of the Arabidopsis CGI-58 homologue produces Chanarin—Dorfman-like lipid droplet accumulation in plants by James, Christopher N., Horn, Patrick J., Case, Charlene R., Gidda, Satinder K., Zhang, Daiyuan, Mullen, Robert T., Dyer, John M., Anderson, Richard G. W., Chapman, Kent D.

“…CGI-58 is the defective gene in the human neutral lipid storage disease called Chanarin-Dorfman syndrome. This disorder causes intracellular lipid droplets to…”
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Cavin-3 dictates the balance between ERK and Akt signaling by Hernandez, Victor J, Weng, Jian, Ly, Peter, Pompey, Shanica, Dong, Hongyun, Mishra, Lopa, Schwarz, Margaret, Anderson, Richard G W, Michaely, Peter

“…Cavin-3 is a tumor suppressor protein of unknown function. Using both in vivo and in vitro approaches, we show that cavin-3 dictates the balance between ERK…”
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Caveolin regulation of endothelial function by Minshall, Richard D, Sessa, William C, Stan, Radu V, Anderson, Richard G W, Malik, Asrar B

“…Caveolae are the sites in the cell membrane responsible for concentrating an array of signaling molecules critical for cell function. Recent studies have begun…”
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Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton by Mundy, Dorothy I, Machleidt, Thomas, Ying, Yun-shu, Anderson, Richard G W, Bloom, George S

“…Live cell, time-lapse microscopy was used to study trafficking of caveolin-1-GFP in stably expressing CHO cells. Multiple cytological and biochemical tests…”
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Identification of a novel N-terminal hydrophobic sequence that targets proteins to lipid droplets by Zehmer, John K, Bartz, René, Liu, Pingsheng, Anderson, Richard G.W

“…AAM-B is a putative methyltransferase that is a resident protein of lipid droplets. We have identified an N-terminal 28 amino acid hydrophobic sequence that is…”
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Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic by Bartz, René, Li, Wen-Hong, Venables, Barney, Zehmer, John K, Roth, Mary R, Welti, Ruth, Anderson, Richard G.W, Liu, Pingsheng, Chapman, Kent D

“…Lipid droplets are accumulations of neutral lipids surrounded by a monolayer of phospholipids and associated proteins. Recent proteomic analysis of isolated…”
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Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets by Zehmer, John K, Bartz, René, Bisel, Blaine, Liu, Pingsheng, Seemann, Joachim, Anderson, Richard G.W

“…Lipid droplets are sites of neutral lipid storage thought to be actively involved in lipid homeostasis. A popular model proposes that droplets are formed in…”
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Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content by Mundy, Dorothy I, Li, Wei Ping, Luby-Phelps, Katherine, Anderson, Richard G W

“…Caveolin-1 is an integral membrane protein of plasma membrane caveolae. Here we report that caveolin-1 collects at the cytosolic surface of lysosomal membranes…”
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Function of Caveolae in Ca2+ Entry and Ca2+‐Dependent Signal Transduction by Isshiki, Masashi, Anderson, Richard G. W.

“…The correct spatial and temporal control of Ca2+ signaling is essential for such cellular activities as fertilization, secretion, motility, and cell division…”
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Role of plasmalemmal caveolae in signal transduction by Shaul, P W, Anderson, R G

“…Caveolae are specialized plasmalemmal microdomains originally studied in numerous cell types for their involvement in the transcytosis of macromolecules. They…”
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The N Terminus Controls Sterol Binding while the C Terminus Regulates the Scaffolding Function of OSBP by Wang, Ping-Yuan, Weng, Jian, Lee, Sungsoo, Anderson, Richard G.W.

“…Previously we reported that when cell cholesterol is acutely lowered with β-methyl-cyclodextrin the amount of activated ERK1/2 in caveolae dramatically…”
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