Search Results - "Anderson, Lyndsey"

Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq by Hawkins, Nicole A, Zachwieja, Nicole J, Miller, Alison R, Anderson, Lyndsey L, Kearney, Jennifer A

“…A substantial number of mutations have been identified in voltage-gated sodium channel genes that result in various forms of human epilepsy. SCN1A mutations…”
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Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid in a Mouse Model of Dravet Syndrome by Anderson, Lyndsey L, Low, Ivan K, Banister, Samuel D, McGregor, Iain S, Arnold, Jonathon C

“…Cannabis sativa produces a complex mixture of many bioactive molecules including terpenophenolic compounds known as phytocannabinoids. Phytocannabinoids come…”
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Cannabinoid Interactions with Cytochrome P450 Drug Metabolism: a Full-Spectrum Characterization by Doohan, Peter T., Oldfield, Lachlan D., Arnold, Jonathon C., Anderson, Lyndsey L.

“…Medicinal cannabis use has increased exponentially with widespread legalization around the world. Cannabis-based products are being used for numerous health…”
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Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions by Anderson, Lyndsey L., Absalom, Nathan L., Abelev, Sarah V., Low, Ivan K., Doohan, Peter T., Martin, Lewis J., Chebib, Mary, McGregor, Iain S., Arnold, Jonathon C.

“…Objective Cannabidiol (CBD) has been approved by the US Food and Drug Administration (FDA) to treat intractable childhood epilepsies, such as Dravet syndrome…”
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Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations by Anderson, Lyndsey L., Etchart, Maia G., Bahceci, Dilara, Golembiewski, Taliesin A., Arnold, Jonathon C.

“…Cannabis is a complex mixture of hundreds of bioactive molecules. This provides the potential for pharmacological interactions between cannabis constituents, a…”
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Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a+/- mouse model of Dravet syndrome by Anderson, Lyndsey L, Bahceci, Dilara A, Hawkins, Nicole A, Everett-Morgan, Declan, Banister, Samuel D, Kearney, Jennifer A, Arnold, Jonathon C

“…A purified preparation of cannabidiol (CBD), a cannabis constituent, has been approved for the treatment of intractable childhood epilepsies such as Dravet…”
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Interactions between cannabidiol and Δ9‐tetrahydrocannabinol in modulating seizure susceptibility and survival in a mouse model of Dravet syndrome by Anderson, Lyndsey L., Low, Ivan K., McGregor, Iain S., Arnold, Jonathon C.

“…Background and Purpose Extracts from the cannabis plant can dramatically improve the health of children suffering from refractory epilepsies such as Dravet…”
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Citalopram and Cannabidiol: In Vitro and In Vivo Evidence of Pharmacokinetic Interactions Relevant to the Treatment of Anxiety Disorders in Young People by Anderson, Lyndsey L., Doohan, Peter T., Oldfield, Lachlan, Kevin, Richard C., Arnold, Jonathon C., Berger, Maximus, Amminger, G. Paul, McGregor, Iain S.

“…Cannabidiol (CBD), a major nonintoxicating constituent of cannabis, exhibits anxiolytic properties in preclinical and human studies and is of interest as a…”
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Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy by Anderson, Lyndsey L., Heblinski, Marika, Absalom, Nathan L., Hawkins, Nicole A., Bowen, Michael T., Benson, Melissa J., Zhang, Fan, Bahceci, Dilara, Doohan, Peter T., Chebib, Mary, McGregor, Iain S., Kearney, Jennifer A., Arnold, Jonathon C.

“…Background and Purpose Cannabis has been used to treat epilepsy for millennia, with such use validated by regulatory approval of cannabidiol (CBD) for Dravet…”
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Cannabinoid‐like compounds found in non‐cannabis plants exhibit antiseizure activity in genetic mouse models of drug‐resistant epilepsy by Yip, Ka Lai, Udoh, Michael, Sharman, Laura A., Harman, Thomas, Bedoya‐Pérez, Miguel, Anderson, Lyndsey L., Banister, Samuel D., Arnold, Jonathon C.

“…Abstract Objective The cannabinoid cannabidiol has established antiseizure effects in drug‐resistant epilepsies such as Dravet syndrome and Lennox–Gastaut…”
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Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome by Anderson, Lyndsey L., Hawkins, Nicole A., Thompson, Christopher H., Kearney, Jennifer A., George, Alfred L.

“…Dravet syndrome, an epileptic encephalopathy affecting children, largely results from heterozygous loss-of-function mutations in the brain voltage-gated sodium…”
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A Potential Drug-Gene-Drug Interaction Between Cannabidiol, CYP2D64, and Fluoxetine: A Case Report by Anderson, Lyndsey L., Arnold, Jonathon C., McGregor, Iain S., Nation, Tamara R.

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The endocannabinoid system impacts seizures in a mouse model of Dravet syndrome by Anderson, Lyndsey L., Doohan, Peter T., Hawkins, Nicole A., Bahceci, Dilara, Garai, Sumanta, Thakur, Ganesh A., Kearney, Jennifer A., Arnold, Jonathon C.

“…Dravet syndrome is a catastrophic childhood epilepsy with multiple seizure types that are refractory to treatment. The endocannabinoid system regulates…”
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A high seizure burden increases several prostaglandin species in the hippocampus of a Scn1a+/- mouse model of Dravet syndrome by Zhou, Cilla, Satpute, Vaishali, Yip, Ka Lai, Anderson, Lyndsey L., Hawkins, Nicole, Kearney, Jennifer, Arnold, Jonathon C.

“…Dravet syndrome is an intractable epilepsy with a high seizure burden that is resistant to current anti-seizure medications. There is evidence that…”
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Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels by Milligan, Carol J, Anderson, Lyndsey L, McGregor, Iain S, Arnold, Jonathon C, Petrou, Steven

“…Cannabis contains cannabidiol (CBD), the main non-psychoactive phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in the…”
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The anticonvulsant phytocannabinoids CBGVA and CBDVA inhibit recombinant T-type channels by Udoh, Michael, Bladen, Chris, Heblinski, Marika, Luo, Jia Lin, Janve, Vaishali S., Anderson, Lyndsey L., McGregor, Iain S., Arnold, Jonathon C.

“…Introduction: Cannabidiol (CBD) has been clinically approved for intractable epilepsies, offering hope that novel anticonvulsants in the phytocannabinoid class…”
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A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats by Arnold, Jonathon C., Occelli Hanbury-Brown, Cassandra V., Anderson, Lyndsey L., Bedoya-Pérez, Miguel A., Udoh, Michael, Sharman, Laura A., Raymond, Joel S., Doohan, Peter T., Ametovski, Adam, McGregor, Iain S.

“…Abstract Medicinal cannabis is being used worldwide and there is increasing use of novel cannabis products in the community. Cannabis contains the major…”
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Cannabichromene, Related Phytocannabinoids, and 5‑Fluoro-cannabichromene Have Anticonvulsant Properties in a Mouse Model of Dravet Syndrome by Anderson, Lyndsey L, Ametovski, Adam, Lin Luo, Jia, Everett-Morgan, Declan, McGregor, Iain S, Banister, Samuel D, Arnold, Jonathon C

“…Cannabis-based products are increasingly being used to treat refractory childhood epilepsies such as Dravet syndrome. Cannabis contains at least 140…”
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In vitro evaluation of the interaction of the cannabis constituents cannabichromene and cannabichromenic acid with ABCG2 and ABCB1 transporters by Etchart, Maia G., Anderson, Lyndsey L., Ametovski, Adam, Jones, Peter M., George, Anthony M., Banister, Samuel D., Arnold, Jonathon C.

“…Cannabichromene (CBC) and cannabichromenic acid (CBCA) are cannabis constituents currently under evaluation for their therapeutic potential, but their…”
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MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy by Harman, Thomas, Udoh, Michael, McElroy, Dan L, Anderson, Lyndsey L, Kevin, Richard C, Banister, Samuel D, Ametovski, Adam, Markham, Jack, Bladen, Chris, Doohan, Peter T, Greba, Quentin, Laprairie, Robert B, Snutch, Terrance P, McGregor, Iain S, Howland, John G, Arnold, Jonathon C

“…T-type Ca channels (Ca 3) represent emerging therapeutic targets for a range of neurological disorders, including epilepsy and pain. To aid the development and…”
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