Search Results - "Anderson, Judith L"

EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma-Induced Epigenetic Suppression of Osteoblast Differentiation by Adamik, Juraj, Jin, Shunqian, Sun, Quanhong, Zhang, Peng, Weiss, Kurt R, Anderson, Judith L, Silbermann, Rebecca, Roodman, G David, Galson, Deborah L

“…In multiple myeloma, osteolytic lesions rarely heal because of persistent suppressed osteoblast differentiation resulting in a high fracture risk. Herein,…”
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Pharmacologic targeting of the p62 ZZ domain enhances both anti-tumor and bone-anabolic effects of bortezomib in multiple myeloma by Marino, Silvia, Petrusca, Daniela N, Bishop, Ryan T, Anderson, Judith L, Sabol, Hayley M, Ashby, Cody, Layer, Justin H, Cesarano, Annamaria, Davé, Utpal P, Perna, Fabiana, Delgado-Calle, Jesus, Chirgwin, John M, Roodman, G David

“…Multiple myeloma (MM) is a malignancy of plasma cells whose antibody secretion creates proteotoxic stress relieved by the N-end rule pathway, a proteolytic…”
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Osteoclasts are important for bone angiogenesis by Cackowski, Frank C., Anderson, Judith L., Patrene, Kenneth D., Choksi, Rushir J., Shapiro, Steven D., Windle, Jolene J., Blair, Harry C., Roodman, G. David

“…Increased osteoclastogenesis and angiogenesis occur in physiologic and pathologic conditions. However, it is unclear if or how these processes are linked. To…”
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Critical Role of AKT Protein in Myeloma-induced Osteoclast Formation and Osteolysis by Cao, Huiling, Zhu, Ke, Qiu, Lugui, Li, Shuai, Niu, Hanjie, Hao, Mu, Yang, Shengyong, Zhao, Zhongfang, Lai, Yumei, Anderson, Judith L., Fan, Jie, Im, Hee-Jeong, Chen, Di, Roodman, G. David, Xiao, Guozhi

“…Abnormal osteoclast formation and osteolysis are the hallmarks of multiple myeloma (MM) bone disease, yet the underlying molecular mechanisms are incompletely…”
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XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression by Adamik, Juraj, Silbermann, Rebecca, Marino, Silvia, Sun, Quanhong, Anderson, Judith L, Zhou, Dan, Xie, Xiang-Qun, Roodman, G David, Galson, Deborah L

“…Multiple myeloma bone disease (MMBD) is characterized by non-healing lytic bone lesions that persist even after a patient has achieved a hematologic remission…”
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Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis by Petrusca, Daniela N, Toscani, Denise, Wang, Feng-Ming, Park, Cheolkyu, Crean, Colin D, Anderson, Judith L, Marino, Silvia, Mohammad, Khalid S, Zhou, Dan, Silbermann, Rebecca, Sun, Quanhong, Kurihara, Noriyoshi, Galson, Deborah L, Giuliani, Nicola, Roodman, G David

“…In spite of major advances in treatment, multiple myeloma (MM) is currently an incurable malignancy due to the emergence of drug-resistant clones. We…”
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Cloning and Characterization of the Annexin II Receptor on Human Marrow Stromal Cells by Lu, Ganwei, Maeda, Hidefumi, Reddy, Sakamuri V., Kurihara, Noriyoshi, Leach, Robin, Anderson, Judith L., Roodman, G. David

“…Annexin II is a heterotetramer, consisting of two 11-kDa (p11) and two 36-kDa (p36) subunits, that is produced by osteoclasts and stimulates osteoclast…”
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Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease by D'Souza, Sonia, del Prete, Davide, Jin, Shunqian, Sun, Quanhong, Huston, Alissa J., Kostov, Flavia Esteve, Sammut, Benedicte, Hong, Chang-Sook, Anderson, Judith L., Patrene, Kenneth D., Yu, Shibing, Velu, Chinavenmeni S., Xiao, Guozhi, Grimes, H. Leighton, Roodman, G. David, Galson, Deborah L.

“…Protracted inhibition of osteoblast (OB) differentiation characterizes multiple myeloma (MM) bone disease and persists even when patients are in long-term…”
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Synthesis and Pharmacological Evaluation of 3-(3,4-Dichlorophenyl)-1-indanamine Derivatives as Nonselective Ligands for Biogenic Amine Transporters by Yu, Han, Kim, In Jong, Folk, John E, Tian, Xinrong, Rothman, Richard B, Baumann, Michael H, Dersch, Christina M, Flippen-Anderson, Judith L, Parrish, Damon, Jacobson, Arthur E, Rice, Kenner C

“…In our efforts toward developing a nonselective ligand that would block the effects of stimulants such as methamphetamine at dopamine (DA), serotonin (5-HT),…”
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GFI1-Dependent Repression of SGPP1 Increases Multiple Myeloma Cell Survival by Petrusca, Daniela N, Mulcrone, Patrick L, Macar, David A, Bishop, Ryan T, Berdyshev, Evgeny, Suvannasankha, Attaya, Anderson, Judith L, Sun, Quanhong, Auron, Philip E, Galson, Deborah L, Roodman, G David

“…Multiple myeloma (MM) remains incurable for most patients due to the emergence of drug resistant clones. Here we report a p53-independent mechanism responsible…”
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The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema by Deshpande, Nita, Addess, Kenneth J., Bluhm, Wolfgang F., Merino-Ott, Jeffrey C., Townsend-Merino, Wayne, Zhang, Qing, Knezevich, Charlie, Xie, Lie, Chen, Li, Feng, Zukang, Kramer Green, Rachel, Flippen-Anderson, Judith L., Westbrook, John, Berman, Helen M., Bourne, Philip E.

“…The Protein Data Bank (PDB) is the central worldwide repository for three-dimensional (3D) structure data of biological macromolecules. The Research…”
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Synthesis and Biological Activity of Novel Neuroprotective Diketopiperazines by Prakash, K.R.C, Tang, Y, Kozikowski, Alan P, Flippen-Anderson, Judith L, Knoblach, Susan M, Faden, Alan I

“…The cyclic dipeptide cyclo[His-Pro] (CHP) is synthesized endogenously de novo and as a breakdown product of thyrotropin-releasing hormone (TRH), a tripeptide…”
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Probes for Narcotic Receptor Mediated Phenomena. 19. Synthesis of (+)-4-[(.alpha.R)-.alpha.-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide .delta. Opioid Receptor Agonist by Calderon, Silvia N, Rothman, Richard B, Porreca, Frank, Flippen-Anderson, Judith L, McNutt, Robert W, Xu, Heng, Smith, Larren E, Bilsky, Edward J, Davis, Peg, Rice, Kenner C

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X-ray studies on ligands by Deschamps, Jeffrey R., Flippen-Anderson, Judith L., George, Clifford

“…Advances in x‐ray crystallographic data collection, structure solution, and refinement/validation have reduced the time required and expanded the range of…”
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Design, Synthesis, and Monoamine Transporter Binding Site Affinities of Methoxy Derivatives of Indatraline by Gu, Xiao-Hui, Yu, Han, Jacobson, Arthur E, Rothman, Richard B, Dersch, Christina M, George, Clifford, Flippen-Anderson, Judith L, Rice, Kenner C

“…A series of methoxy-containing derivatives of indatraline 13a − f and 17 were synthesized, and their binding affinities for the dopamine, serotonin, and…”
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Embracing Uncertainty: The Interface of Bayesian Statistics and Cognitive Psychology by Anderson, Judith L.

“…Ecologists working in conservation and resource management are discovering the importance of using Bayesian analytic methods to deal explicitly with…”
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Portrayals of Older Adults in U.S. and Indian Magazine Advertisements: A Cross-Cultural Comparison by Raman, Priya, Harwood, Jake, Weis, Deborah, Anderson, Judith L., Miller, Grace

“…The authors investigated cross-cultural media portrayals of older adults and other age groups across the lifespan through a content analysis of U.S. and Indian…”
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Unfolding of an alpha-helix in peptide crystals by solvation: conformational fragility in a heptapeptide by Karle, I L, Flippen-Anderson, J L, Uma, K, Balaram, P

“…The structure of the peptide Boc-Val-Ala-Leu-Aib-Val-Ala-Leu-OMe has been determined in crystals obtained from a dimethylsulfoxide-isopropanol mixture. Crystal…”
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Methyl Analogues of the Experimental Alzheimer Drug Phenserine:  Synthesis and Structure/Activity Relationships for Acetyl- and Butyrylcholinesterase Inhibitory Action by Yu, Qian-sheng, Holloway, Harold W, Flippen-Anderson, Judith L, Hoffman, Brian, Brossi, Arnold, Greig, Nigel H

“…With the goal of developing potential Alzheimer's pharmacotherapeutics, we have synthesized a series of novel analogues of the potent anticholinesterases…”
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Synthesis of polyazapolycyclic caged polynitramines by Nielsen, Arnold T., Chafin, Andrew P., Christian, Stephen L., Moore, Donald W., Nadler, Melvin P., Nissan, Robin A., Vanderah, David J., Gilardi, Richard D., George, Clifford F., Flippen-Anderson, Judith L.

“…Syntheses of new polyazapolycyclic caged polynitramines are described. Sequentially reacting…”
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