Search Results - "Anderson, Jeffrey R."

The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo by Gao, Wei, Kim, Jin-Yong, Anderson, Jeffrey R, Akopian, Tatos, Hong, Seungpyo, Jin, Ying-Yu, Kandror, Olga, Kim, Jong-Woo, Lee, In-Ae, Lee, Sun-Young, McAlpine, James B, Mulugeta, Surafel, Sunoqrot, Suhair, Wang, Yuehong, Yang, Seung-Hwan, Yoon, Tae-Mi, Goldberg, Alfred L, Pauli, Guido F, Suh, Joo-Won, Franzblau, Scott G, Cho, Sanghyun

“…Drug-resistant tuberculosis (TB) has lent urgency to finding new drug leads with novel modes of action. A high-throughput screening campaign of >65,000…”
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Metabolite Profiling and Classification of DNA-Authenticated Licorice Botanicals by Simmler, Charlotte, Anderson, Jeffrey R, Gauthier, Laura, Lankin, David C, McAlpine, James B, Chen, Shao-Nong, Pauli, Guido F

“…Raw licorice roots represent heterogeneous materials obtained from mainly three Glycyrrhiza species. G. glabra, G. uralensis, and G. inflata exhibit marked…”
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Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms by Hajirahimkhan, Atieh, Simmler, Charlotte, Yuan, Yang, Anderson, Jeffrey R, Chen, Shao-Nong, Nikolić, Dejan, Dietz, Birgit M, Pauli, Guido F, van Breemen, Richard B, Bolton, Judy L

“…The increased cancer risk associated with hormone therapies has encouraged many women to seek non-hormonal alternatives including botanical supplements such as…”
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Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans by Evans, Patrick D, Gilbert, Sandra L, Mekel-Bobrov, Nitzan, Vallender, Eric J, Anderson, Jeffrey R, Vaez-Azizi, Leila M, Tishkoff, Sarah A, Hudson, Richard R, Lahn, Bruce T

“…The gene Microcephalin (MCPH1) regulates brain size and has evolved under strong positive selection in the human evolutionary lineage. We show that one genetic…”
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Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiens by Dorus, Steve, Vallender, Eric J., Evans, Patrick D., Anderson, Jeffrey R., Gilbert, Sandra L., Mahowald, Michael, Wyckoff, Gerald J., Malcom, Christine M., Lahn, Bruce T.

“…Human evolution is characterized by a dramatic increase in brain size and complexity. To probe its genetic basis, we examined the evolution of genes involved…”
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Genetic Heterogeneity in Colorectal Cancer Associations Between African and European Americans by Kupfer, Sonia S, Anderson, Jeffrey R, Hooker, Stanley, Skol, Andrew, Kittles, Rick A, Keku, Temitope O, Sandler, Robert S, Ellis, Nathan A

“…Background & Aims Genome-wide association studies of colorectal cancer (CRC) have identified risk variants in 10 genomic regions. None of these studies…”
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In vivo quantification of murine aortic cyclic strain, motion, and curvature: Implications for abdominal aortic aneurysm growth by Goergen, Craig J., Barr, Kyla N., Huynh, Diem T., Eastham-Anderson, Jeffrey R., Choi, Gilwoo, Hedehus, Maj, Dalman, Ronald L., Connolly, Andrew J., Taylor, Charles A., Tsao, Philip S., Greve, Joan M.

“…Purpose To develop methods to quantify cyclic strain, motion, and curvature of the murine abdominal aorta in vivo. Materials and Methods C57BL/6J and apoE−/−…”
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Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans by Evans, Patrick D., Anderson, Jeffrey R., Vallender, Eric J., Gilbert, Sandra L., Malcom, Christine M., Dorus, Steve, Lahn, Bruce T.

“…A prominent trend in the evolution of humans is the progressive enlargement of the cerebral cortex. The ASPM (Abnormal spindle-like microcephaly associated)…”
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Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo by Dietz, Birgit M., Hagos, Ghenet K., Eskra, Jillian N., Wijewickrama, Gihani T., Anderson, Jeffrey R., Nikolic, Dejan, Guo, Jian, Wright, Brian, Chen, Shao-Nong, Pauli, Guido F., van Breemen, Richard B., Bolton, Judy L.

“…Scope Hops contain the phytoestrogen, 8‐prenylnaringenin, and the cytoprotective compound, xanthohumol (XH). XH induces the detoxification enzyme,…”
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Genetic associations in the vitamin D receptor and colorectal cancer in African Americans and Caucasians by Kupfer, Sonia S, Anderson, Jeffrey R, Ludvik, Anton E, Hooker, Stanley, Skol, Andrew, Kittles, Rick A, Keku, Temitope O, Sandler, Robert S, Ruiz-Ponte, Clara, Castellvi-Bel, Sergi, Castells, Antoni, Carracedo, Angel, Ellis, Nathan A

“…Low vitamin D levels are associated with an increased incidence of colorectal cancer (CRC) and higher mortality from the disease. In the US, African Americans…”
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Blow up and global solvability for an absorptive porous medium equation with memory at the boundary by Anderson, Jeffrey R, Deng, Keng

“…Abstract We study the characterization of global solvability versus blow up in finite time for a porous medium model including a balance of internal absorption…”
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Global solvability for the heat equation with boundary flux governed by nonlinear memory by ANDERSON, JEFFREY R., DENG, KENG, DONG, ZHIHUA

“…We introduce the study of global existence and blowup in finite time for the heat equation with flux at the boundary governed by a nonlinear memory term. Via a…”
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Global solvability for a diffusion model with absorption and memory-driven flux at the boundary by Anderson, Jeffrey R., Deng, Keng

“…A general result on global solvability is established for a diffusion–absorption model with memory-driven flux at the boundary. Such a boundary condition has…”
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Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus by Choules, Mary P, Wolf, Nina M, Lee, Hyun, Anderson, Jeffrey R, Grzelak, Edyta M, Wang, Yuehong, Ma, Rui, Gao, Wei, McAlpine, James B, Jin, Ying-Yu, Cheng, Jinhua, Lee, Hanki, Suh, Joo-Won, Duc, Nguyen Minh, Paik, Seungwha, Choe, Jin Ho, Jo, Eun-Kyeong, Chang, Chulhun L, Lee, Jong Seok, Jaki, Birgit U, Pauli, Guido F, Franzblau, Scott G, Cho, Sanghyun

“…ClpC1 is an emerging new target for the treatment of infections, and several cyclic peptides (ecumicin, cyclomarin A, and lassomycin) are known to act on this…”
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A lower bound on the blow up time for solutions of a chemotaxis system with nonlinear chemotactic sensitivity by Anderson, Jeffrey R., Deng, Keng

“…In a recent study, a lower bound is established on the blow up time for solutions of a chemotaxis system, with nonlinear chemotactic sensitivity u(u+1)m−1, set…”
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Ecological thresholds and regime shifts within hydrologically modified rivers: A 75+ year retrospective analysis by Delong, Michael D., Thorp, James H., Anderson, Jeffrey R.

“…Theoretical models have spurred empirical testing to understand how anthropogenic disturbances cause sudden shifts between alternative functional states. Most…”
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A fast diffusion model with memory at the boundary: global solvability in the critical case by Anderson, Jeffrey R.

“…Necessary and sufficient conditions for the global solvability of a slow diffusion model with boundary flux governed by memory have been previously shown to be…”
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Global behavior of solutions to the fast diffusion equation with boundary flux governed by memory by Anderson, Jeffrey R., Deng, Keng, Wang, Qian

“…We study global existence and blow up in finite time for a one‐dimensional fast diffusion equation with memory boundary condition. The problem arises out of a…”
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Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens by Mekel-Bobrov, Nitzan, Gilbert, Sandra L, Evans, Patrick D, Vallender, Eric J, Anderson, Jeffrey R, Hudson, Richard R, Tishkoff, Sarah A, Lahn, Bruce T

“…The gene ASPM (abnormal spindle-like microcephaly associated) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens…”
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High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads by Wolf, Nina M, Lee, Hyun, Choules, Mary P, Pauli, Guido F, Phansalkar, Rasika, Anderson, Jeffrey R, Gao, Wei, Ren, Jinhong, Santarsiero, Bernard D, Lee, Hanki, Cheng, Jinhua, Jin, Ying-Yu, Ho, Ngoc Anh, Duc, Nguyen Minh, Suh, Joo-Won, Abad-Zapatero, Celerino, Cho, Sanghyun

“…Addressing the urgent need to develop novel drugs against drug-resistant Mycobacterium tuberculosis (M. tb) strains, ecumicin (ECU) and rufomycin I (RUFI) are…”
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