Search Results - "Anderson, H Clarke"

Tissue-Nonspecific Alkaline Phosphatase and Plasma Cell Membrane Glycoprotein-1 are Central Antagonistic Regulators of Bone Mineralization by Hessle, Lovisa, Johnson, Kristen A., Anderson, H. Clarke, Narisawa, Sonoko, Sali, Adnan, Goding, James W., Terkeltaub, Robert, Millán, José Luis

“…Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation and growth in the interior of membrane-limited matrix vesicles (MVs) and by…”
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Nfat1 regulates adult articular chondrocyte function through its age‐dependent expression mediated by epigenetic histone methylation by Rodova, Marianna, Lu, Qinghua, Li, Ye, Woodbury, Brent G, Crist, Jamie D, Gardner, Brian M, Yost, John G, Zhong, Xiao‐bo, Anderson, H Clarke, Wang, Jinxi

“…The development of disease‐modifying pharmacologic therapy for osteoarthritis (OA) currently faces major obstacles largely because the regulatory mechanisms…”
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Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins by Nahar, Niru N., Missana, Liliana R., Garimella, Rama, Tague, Sarah E., Anderson, H. Clarke

“…Matrix vesicles (MVs) are well positioned in the growth plate to serve as a carrier of morphogenetic information to nearby chondrocytes and osteoblasts. Bone…”
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Impaired Calcification Around Matrix Vesicles of Growth Plate and Bone in Alkaline Phosphatase-Deficient Mice by Anderson, H. Clarke, Sipe, Joseph B., Hessle, Lovisa, Dhamyamraju, Rama, Atti, Elisa, Camacho, Nancy P., Millán, José Luis

“…The presence of skeletal hypomineralization was confirmed in mice lacking the gene for bone alkaline phosphatase, ie, the tissue-non-specific isozyme of…”
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Nature of phosphate substrate as a major determinant of mineral type formed in matrix vesicle-mediated in vitro mineralization: An FTIR imaging study by Garimella, Rama, Bi, Xiaohong, Anderson, H. Clarke, Camacho, Nancy P.

“…Membrane-bound extracellular matrix vesicles play an important role in the de novo initiation and propagation of calcium–phosphate mineral formation in…”
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Role of extracellular membrane vesicles in the pathogenesis of various diseases, including cancer, renal diseases, atherosclerosis, and arthritis by Anderson, H Clarke, Mulhall, Douglas, Garimella, Rama

“…Extracellular membrane vesicles (MVs) 30–1000 nm in diameter and of varying cellular origins are increasingly recognized for their participation in a range of…”
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Expression and Synthesis of Bone Morphogenetic Proteins by Osteoclasts: A Possible Path to Anabolic Bone Remodeling by Garimella, Rama, Tague, Sarah E, Zhang, Jianghong, Belibi, Frank, Nahar, Niru, Sun, Ben Hua, Insogna, Karl, Wang, Jinxi, Anderson, H. Clarke

“…Skeletal remodeling is a finely orchestrated process coupling bone formation to bone resorption. The dynamics of coupling is regulated by the microenvironment…”
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Localization of bone morphogenetic proteins (BMPs)-2, -4, and -6 within megakaryocytes and platelets by Sipe, Joseph B., Zhang, Jianghong, Waits, Chad, Skikne, Barry, Garimella, Rama, Anderson, H. Clarke

“…In this study, we localized bone morphogenetic proteins (BMPs), proteins known to induce ectopic osteogenesis, within megakaryocytes and in lysates of human…”
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Matrix vesicles and calcification by Anderson, H Clarke

“…Matrix vesicles (MVs) are extracellular, 100 nM in diameter, membrane-invested particles selectively located at sites of initial calcification in cartilage,…”
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Immunohistochemical localization of bone morphogenetic proteins (BMPs) 2, 4, 6, and 7 during induced heterotopic bone formation by McCullough, Kirk A., Waits, Chad A., Garimella, Rama, Tague, Sarah E., Sipe, Joseph B., Anderson, H. Clarke

“…The distribution and staining intensity of bone morphogenetic proteins (BMPs) 2, 4, 6, and 7 were assessed by immunohistochemistry in ectopic bone induced in…”
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Biological characterization of preclinical Bioluminescent Osteosarcoma Orthotopic Mouse (BOOM) model: A multi-modality approach by Garimella, Rama, Eskew, Jeff, Bhamidi, Priyanka, Vielhauer, George, Hong, Yan, Anderson, H. Clarke, Tawfik, Ossama, Rowe, Peter

“…Abstract Osteosarcoma (OS) is a bone malignancy that affects children and adolescents. It is a highly aggressive tumor and typically metastasizes to lungs…”
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The role of matrix vesicles in growth plate development and biomineralization by Anderson, H Clarke, Garimella, Rama, Tague, Sarah E

“…Skeletal cells control the initiation of mineralization in vivo and determine the selective distribution pattern of mineralization by releasing…”
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Sustained Osteomalacia of Long Bones Despite Major Improvement in Other Hypophosphatasia-Related Mineral Deficits in Tissue Nonspecific Alkaline Phosphatase/Nucleotide Pyrophosphatase Phosphodiesterase 1 Double-Deficient Mice by Anderson, H. Clarke, Harmey, Dympna, Camacho, Nancy P., Garimella, Rama, Sipe, Joseph B., Tague, Sarah, Bi, Xiaohong, Johnson, Kristen, Terkeltaub, Robert, Millán, José Luis

“…We have shown previously that the hypomineralization defects of the calvarium and vertebrae of tissue nonspecific alkaline phosphatase (TNAP)-deficient ( Akp2…”
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Evidence of the Presence of a Specific ATPase Responsible for ATP-initiated Calcification by Matrix Vesicles Isolated from Cartilage and Bone by Hsu, H H, Anderson, H C

“…Accumulating evidence indicates that calcification by isolated mammalian matrix vesicles (MVs) can be initiated by ATP. Since ATP can be hydrolyzed by either a…”
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Selective synthesis of bone morphogenetic proteins-1, -3, -4 and bone sialoprotein may be important for osteoinduction by Saos-2 cells by ANDERSON, H. Clarke, REYNOLDS, Paul R, HSU, Howard H. T, MISSANA, Lilliana, MASUHARA, Kensaku, MOYLAN, Paul E, ROACH, Helmtrude I

“…An ability to induce new bone formation at a required site would represent a considerable advance in bone repair and tissue engineering. It has been shown that…”
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Effect of 25-hydroxyvitamin D3 and 1 α,25 dihydroxyvitamin D3 on differentiation and apoptosis of human osteosarcoma cell lines by Thompson, Lindsey, Wang, Shanshan, Tawfik, Ossama, Templeton, Kimberly, Tancabelic, Jakica, Pinson, David, Anderson, H. Clarke, Keighley, John, Garimella, Rama

“…Osteosarcoma (OS) is a malignant bone tumor predominantly affecting children and adolescents. OS has a 60% survival rate with current treatments; hence, there…”
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Expression of bone morphogenetic proteins and their receptors in the bone marrow megakaryocytes of GATA-1(low) mice: a possible role in osteosclerosis by Garimella, Rama, Kacena, Melissa A, Tague, Sarah E, Wang, Jinxi, Horowitz, Mark C, Anderson, H Clarke

“…The mechanism of osteosclerosis associated with myelofibrosis in megakaryocyte (MK)-related myeloproliferative disorders is largely unknown. However, growth…”
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The role of matrix vesicles in physiological and pathological calcification by Anderson, H Clarke

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Histological characterization of bone marrow in ectopic bone, induced by devitalized Saos-2 human osteosarcoma cells by Nahar, Niru N, Tague, Sarah E, Wang, Jinxi, Danley, Marsha, Garimella, Rama, Anderson, H Clarke

“…Devitalized Saos-2, cultured human osteosarcoma cells, or guanidinium-hydrochloride (GuHCl) extracts of these cells, induce ectopic bone and marrow formation…”
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Bone Morphogenetic Protein (BMP) Localization in Developing Human and Rat Growth Plate, Metaphysis, Epiphysis, and Articular Cartilage by Anderson, H. Clarke, Hodges, Peter T, Aguilera, Ximena M, Missana, Lilliana, Moylan, Paul E

“…We assessed the distribution and relative staining intensity of bone morphogenetic protein (BMP)-1–7 by immunohistochemistry in tibial growth plates,…”
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