Search Results - "Anderson, Donald C"

Pharmacogenetics and Pharmacogenomics in Drug Development and Regulatory Decision Making: Report of the First FDA-PWG-PhRMA-DruSafe Workshop by Lesko, Lawrence J., Salerno, Ronald A., Spear, Brian B., Anderson, Donald C., Anderson, Timothy, Brazell, Celia, Collins, Jerry, Dorner, Andrew, Essayan, David, Gomez-Mancilla, Baltazar, Hackett, Joseph, Huang, Shiew-Mei, Ide, Susan, Killinger, Joanne, Leighton, John, Mansfield, Elizabeth, Meyer, Robert, Ryan, Stephen G., Schmith, Virginia, Shaw, Peter, Sistare, Frank, Watson, Mark, Worobec, Alexandra

“…The use of pharmacogenetics and pharmacogenomics in the drug development process, and in the assessment of such data submitted to regulatory agencies by…”
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Heterogeneity of Expression of E- and P-Selectins In Vivo by Eppihimer, Michael J, Wolitzky, Barry, Anderson, Donald C, Labow, Mark A, Granger, D. Neil

“…A novel technique involving radiolabeled monoclonal antibodies was used to characterize and compare the expression of E- and P-selectin on unstimulated,…”
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Linezolid for the treatment of community- acquired pneumonia in hospitalized children by KAPLAN, SHELDON L, PATTERSON, LORI, EDWARDS, KATHRYN M, AZIMI, PARVIN H, BRADLEY, JOHN S, BLUMER, JEFFREY L, TAN, TINA Q, LOBECK, FRANK G, ANDERSON, DONALD C

“…OBJECTIVE.To determine the safety, tolerance, pharmacokinetics and efficacy of linezolid, a new oxazolidinone antibiotic in the treatment of community-acquired…”
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Myocardial ischemia-reperfusion injury in CD18- and ICAM-1-deficient mice by Palazzo, A J, Jones, S P, Girod, W G, Anderson, D C, Granger, D N, Lefer, D J

“…Previous studies have demonstrated that circulating neutrophils (PMNs) contribute to the pathophysiology of myocardial ischemia-reperfusion (MI/R) injury…”
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Diabetes exacerbates inflammatory responses to ischemia-reperfusion by PANES, J, KUROSE, I, RODRIGUEZ-VACA, D, ANDERSON, D. C, MIYASAKA, M, TSO, P, GRANGER, N

“…Diabetes is associated with an increased incidence of ischemic organ damage. The objectives of present study were to compare the leukocyte-endothelial cell…”
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P-selectin antibody reduces hemorrhage and infarct volume resulting from MCA occlusion in the rat by Goussev, Anton V, Zhang, Zhenggang, Anderson, Donald C, Chopp, Michael

“…We investigated the effect of an anti-P-selectin antibody (RMP-1) on ischemic cell damage and hemorrhage after transient middle cerebral artery occlusion…”
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Effects of Chronic Arterial Hypertension on Constitutive and Induced Intercellular Adhesion Molecule-1 Expression In Vivo by Komatsu, Shunichiro, Panes, Julian, Russell, Janice M, Anderson, Donald C, Muzykantov, Vladimir R, Miyasaka, Masayuki, Granger, D. Neil

“…Recent reports indicate that bacterial endotoxin (lipopolysaccharide) and cytokines elicit a more profound increase in the surface expression of intercellular…”
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VCAM-1, but Not ICAM-1 or MAdCAM-1, Immunoblockade Ameliorates DSS-Induced Colitis in Mice by SORIANO, Antonio, SALAS, Antonio, SALAS, Azucena, SANS, Miquel, GIRONELLA, Meritxell, ELENA, Monserrat, ANDERSON, Donald C, PIQUE, Josep M, PANES, Julian

“…Adhesion molecule immunoneutralization is envisioned as a promising therapy for inflammatory bowel disease, but the relative value of selective blockade of…”
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Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the wistar rat by RUI LAN ZHANG, CHOPP, M, NING JIANG, WEN XUE TANG, PROSTAK, J, MANNING, A. M, ANDERSON, D. C, FEUERSTEIN, G. Z, BARONE, F. C

“…Postischemic cerebral inflammation may contribute to ischemic cell damage. Intercellular adhesion molecule-1 (ICAM-1) is a glycoprotein expressed on…”
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Inhibition of Nitric Oxide Production: Mechanisms of Vascular Albumin Leakage by Kurose, Iwao, Kubes, Paul, Wolf, Robert, Anderson, Donald C, Paulson, James, Miyasaka, Masayuki, Granger, Neil D

“…The mechanisms by which nitric oxide modulates microvascular albumin exchange were investigated by monitoring leukocyte-endothelial cell adhesion and…”
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Differences among beef sire breeds and relationships between terrain use and performance when daughters graze foothill rangelands as cows by VanWagoner, Harv C., Bailey, Derek W., Kress, Donald D., Anderson, Donald C., Davis, Kathleen C.

“…A study was conducted on foothill rangeland to determine if breed of sire affected grazing distribution patterns and to evaluate relationships between…”
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Differential role of selectins in experimental colitis by Sans, Miquel, Salas, Azucena, Soriano, Antonio, Prats, Neus, Gironella, Meritxell, Pizcueta, Pilar, Elena, Montserrat, Anderson, Donald C., Piqué, Josep M., Panés, Julián

“…Background & Aims: The role of selectins in experimental colitis remains unknown. The aims of this study were to characterize the time-course expression of…”
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Inflammation in the course of early myocardial ischemia by Entman, M L, Michael, L, Rossen, R D, Dreyer, W J, Anderson, D C, Taylor, A A, Smith, C W

“…Experimental models of acute ischemic myocardial injury indicate that the inflammatory response after the ischemic event contributes to tissue damage. This is…”
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Mechanisms involved in Helicobacter pylori-induced inflammation by Yoshida, N, Granger, D N, Evans, Jr, D J, Evans, D G, Graham, D Y, Anderson, D C, Wolf, R E, Kvietys, P R

“…Helicobacter pylori infection is associated with mucosal inflammation. The aims of the present study were to assess whether a water extract of H. pylori…”
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Coronary endothelial P-selectin in pathogenesis of myocardial ischemia-reperfusion injury by Palazzo, A J, Jones, S P, Anderson, D C, Granger, D N, Lefer, D J

“…We investigated in vivo coronary P-selectin expression and its pathophysiological consequences in a murine model of myocardial ischemia-reperfusion (MI/R)…”
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Quantitation of intracellular Mac-1 (CD11b/CD18) pools in human neutrophils by Jones, D H, Anderson, D C, Burr, B L, Rudloff, H E, Smith, C W, Krater, S S, Schmalstieg, F C

“…The adhesive glycoprotein Mac-1 (CD11b/CD18) of the CD11/CD18 complex contributes to multiple neutrophil inflammatory functions. Activation of neutrophils by…”
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Modulation of P-selectin expression in the postischemic intestinal microvasculature by Eppihimer, M J, Russell, J, Anderson, D C, Epstein, C J, Laroux, S, Granger, D N

“…The dual radiolabeled monoclonal antibody technique was used to 1) define the magnitude and kinetics of P-selectin expression in murine small intestine exposed…”
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Endothelial cell adhesion molecule expression in gene-targeted mice by Eppihimer, M J, Russell, J, Anderson, D C, Wolitzky, B A, Granger, D N

“…Gene-targeted mice are now routinely employed as tools for defining the contribution of different leukocyte and endothelial cell adhesion molecules to the…”
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Complement Receptor 3 (CR3, Mac-1, Integrin α Mβ 2, CD11b/CD18) Is Required for Tyrosine Phosphorylation of Paxillin in Adherent and Nonadherent Neutrophils by Graham, Irene L., Anderson, Donald C., Holers, V. Michael, Brown, Eric J.

“…Expression of the leukocyte (β 2) integrins is required for many functions of activated neutrophils (PMN), even when there is no recognized ligand for any β 2…”
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Nitric oxide modulates gut ischemia-reperfusion-induced P-selectin expression in murine liver by Horie, Y, Wolf, R, Anderson, D C, Granger, D N

“…Reperfusion of ischemic intestine is associated with P-selectin-dependent adhesion of leukocytes in the liver microcirculation. The objective of this study was…”
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