Search Results - "Anderson, Daniel G."

Engineering circular RNA for potent and stable translation in eukaryotic cells by Wesselhoeft, R. Alexander, Kowalski, Piotr S., Anderson, Daniel G.

“…Messenger RNA (mRNA) has broad potential for application in biological systems. However, one fundamental limitation to its use is its relatively short…”
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The clinical progress of mRNA vaccines and immunotherapies by Barbier, Ann J., Jiang, Allen Yujie, Zhang, Peng, Wooster, Richard, Anderson, Daniel G.

“…The emergency use authorizations (EUAs) of two mRNA-based severe acute respiratory syndrome coronavirus (SARS-CoV)-2 vaccines approximately 11 months after…”
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Materials for non-viral intracellular delivery of messenger RNA therapeutics by Kauffman, Kevin J., Webber, Matthew J., Anderson, Daniel G.

“…Though therapeutics based on messenger RNA (mRNA) have broad potential in applications such as protein replacement therapy, cancer immunotherapy, and genomic…”
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Advances in the delivery of RNA therapeutics: from concept to clinical reality by Kaczmarek, James C, Kowalski, Piotr S, Anderson, Daniel G

“…The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic…”
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Bio-Inspired Polymer Composite Actuator and Generator Driven by Water Gradients by Ma, Mingming, Guo, Liang, Anderson, Daniel G., Langer, Robert

“…Here we describe the development of a water-responsive polymer film. Combining both a rigid matrix (polypyrrole) and a dynamic network (polyol-borate), strong…”
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Biomaterials for Personalized Cell Therapy by Facklam, Amanda L., Volpatti, Lisa R., Anderson, Daniel G.

“…Cell therapy has already had an important impact on healthcare and provided new treatments for previously intractable diseases. Notable examples include…”
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CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling by Platt, Randall J., Chen, Sidi, Zhou, Yang, Yim, Michael J., Swiech, Lukasz, Kempton, Hannah R., Dahlman, James E., Parnas, Oren, Eisenhaure, Thomas M., Jovanovic, Marko, Graham, Daniel B., Jhunjhunwala, Siddharth, Heidenreich, Matthias, Xavier, Ramnik J., Langer, Robert, Anderson, Daniel G., Hacohen, Nir, Regev, Aviv, Feng, Guoping, Sharp, Phillip A., Zhang, Feng

“…CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we…”
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RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo by Wesselhoeft, R. Alexander, Kowalski, Piotr S., Parker-Hale, Frances C., Huang, Yuxuan, Bisaria, Namita, Anderson, Daniel G.

“…Circular RNAs (circRNAs) are a class of single-stranded RNAs with a contiguous structure that have enhanced stability and a lack of end motifs necessary for…”
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Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium by Patel, Asha Kumari, Kaczmarek, James C., Bose, Suman, Kauffman, Kevin J., Mir, Faryal, Heartlein, Michael W., DeRosa, Frank, Langer, Robert, Anderson, Daniel G.

“…Noninvasive aerosol inhalation is an established method of drug delivery to the lung, and remains a desirable route for nucleic‐acid‐based therapeutics. In…”
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Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver by Miao, Lei, Lin, Jiaqi, Huang, Yuxuan, Li, Linxian, Delcassian, Derfogail, Ge, Yifan, Shi, Yunhua, Anderson, Daniel G.

“…Lipid-like nanoparticles (LNPs) have potential as non-viral delivery systems for mRNA therapies. However, repeated administrations of LNPs may lead to…”
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Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy by Oberli, Matthias A, Reichmuth, Andreas M, Dorkin, J. Robert, Mitchell, Michael J, Fenton, Owen S, Jaklenec, Ana, Anderson, Daniel G, Langer, Robert, Blankschtein, Daniel

“…The induction of a strong cytotoxic T cell response is an important prerequisite for successful immunotherapy against many viral diseases and tumors…”
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Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs by Kaczmarek, James C., Patel, Asha K., Kauffman, Kevin J., Fenton, Owen S., Webber, Matthew J., Heartlein, Michael W., DeRosa, Frank, Anderson, Daniel G.

“…Therapeutic nucleic acids hold great promise for the treatment of disease but require vectors for safe and effective delivery. Synthetic nanoparticle vectors…”
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Ionizable Amino‐Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino‐Alcohols for Tissue Selective mRNA Delivery by Kowalski, Piotr S., Capasso Palmiero, Umberto, Huang, Yuxuan, Rudra, Arnab, Langer, Robert, Anderson, Daniel G.

“…The utility of messenger RNA (mRNA) as a therapy is gaining a broad interest due to its potential for addressing a wide range of diseases, while effective…”
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Optimization of a Degradable Polymer–Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells by Kaczmarek, James C, Kauffman, Kevin J, Fenton, Owen S, Sadtler, Kaitlyn, Patel, Asha K, Heartlein, Michael W, DeRosa, Frank, Anderson, Daniel G

“…mRNA therapeutics hold great potential for treating a variety of diseases through protein-replacement, immunomodulation, and gene editing. However, much like…”
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Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling by Sahay, Gaurav, Querbes, William, Alabi, Christopher, Eltoukhy, Ahmed, Sarkar, Sovan, Zurenko, Christopher, Karagiannis, Emmanouil, Love, Kevin, Chen, Delai, Zoncu, Roberto, Buganim, Yosef, Schroeder, Avi, Langer, Robert, Anderson, Daniel G

“…Detailed analyses of siRNA delivery by lipid nanoparticles reveal major pathways of siRNA internalization and endosomal escape. Despite efforts to understand…”
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CRISPR-mediated direct mutation of cancer genes in the mouse liver by Xue, Wen, Chen, Sidi, Yin, Hao, Tammela, Tuomas, Papagiannakopoulos, Thales, Joshi, Nikhil S., Cai, Wenxin, Yang, Gillian, Bronson, Roderick, Crowley, Denise G., Zhang, Feng, Anderson, Daniel G., Sharp, Phillip A., Jacks, Tyler

“…CRISPR plasmids targeting Pten and p53 , alone and in combination, are delivered by hydrodynamic injection to the liver; the CRISPR-mediated mutations…”
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Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing by Yin, Hao, Song, Chun-Qing, Suresh, Sneha, Wu, Qiongqiong, Walsh, Stephen, Rhym, Luke Hyunsik, Mintzer, Esther, Bolukbasi, Mehmet Fatih, Zhu, Lihua Julie, Kauffman, Kevin, Mou, Haiwei, Oberholzer, Alicia, Ding, Junmei, Kwan, Suet-Yan, Bogorad, Roman L, Zatsepin, Timofei, Koteliansky, Victor, Wolfe, Scot A, Xue, Wen, Langer, Robert, Anderson, Daniel G

“…Efficient Cas9 genome editing in vivo is achieved without viral vectors using chemically modified single-guide RNAs. Efficient genome editing with Cas9–sgRNA…”
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Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses by Wang, Dan, Mou, Haiwei, Li, Shaoyong, Li, Yingxiang, Hough, Soren, Tran, Karen, Li, Jia, Yin, Hao, Anderson, Daniel G, Sontheimer, Erik J, Weng, Zhiping, Gao, Guangping, Xue, Wen

“…CRISPR/Cas9 derived from the bacterial adaptive immunity pathway is a powerful tool for genome editing, but the safety profiles of in vivo delivered Cas9…”
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Supramolecular PEGylation of biopharmaceuticals by Webber, Matthew J., Appel, Eric A., Vinciguerra, Brittany, Cortinas, Abel B., Thapa, Lavanya S., Jhunjhunwala, Siddharth, Isaacs, Lyle, Langer, Robert, Anderson, Daniel G.

“…The covalent modification of therapeutic biomolecules has been broadly explored, leading to a number of clinically approved modified protein drugs. These…”
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Injectable Nano-Network for Glucose-Mediated Insulin Delivery by Gu, Zhen, Aimetti, Alex A, Wang, Qun, Dang, Tram T, Zhang, Yunlong, Veiseh, Omid, Cheng, Hao, Langer, Robert S, Anderson, Daniel G

“…Diabetes mellitus, a disorder of glucose regulation, is a global burden affecting 366 million people across the world. An artificial “closed-loop” system able…”
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