Search Results - "Anderson, DANIEL"

Physical and mechanical properties of PLA, and their functions in widespread applications — A comprehensive review by Farah, Shady, Anderson, Daniel G., Langer, Robert

“…Poly(lactic acid) (PLA), so far, is the most extensively researched and utilized biodegradable aliphatic polyester in human history. Due to its merits, PLA is…”
Get full text

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery by Kowalski, Piotr S., Rudra, Arnab, Miao, Lei, Anderson, Daniel G.

“…mRNA has broad potential as a therapeutic. Current clinical efforts are focused on vaccination, protein replacement therapies, and treatment of genetic…”
Get full text

In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles by Shi, Dennis, Toyonaga, Sho, Anderson, Daniel G.

“…Ex vivo autologous hematopoietic stem cell (HSC) gene therapy has provided new therapies for the treatment of hematological disorders. However, these therapies…”
Get full text

Strategies, design, and chemistry in siRNA delivery systems by Dong, Yizhou, Siegwart, Daniel J., Anderson, Daniel G.

“…Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad classes of diseases due to their ability to reversibly silence…”
Get full text

Delivery technologies for genome editing by Yin, Hao, Kauffman, Kevin J., Anderson, Daniel G.

“…Key Points Genome-editing systems have remarkable potential to treat genetic diseases. However, one of the major challenges facing their implementation is the…”
Get full text

Engineering circular RNA for potent and stable translation in eukaryotic cells by Wesselhoeft, R. Alexander, Kowalski, Piotr S., Anderson, Daniel G.

“…Messenger RNA (mRNA) has broad potential for application in biological systems. However, one fundamental limitation to its use is its relatively short…”
Get full text

Digital Screen Media and Cognitive Development by Anderson, Daniel R, Subrahmanyam, Kaveri

“…In this article, we examine the impact of digital screen devices, including television, on cognitive development. Although we know that young infants and…”
Get full text

The clinical progress of mRNA vaccines and immunotherapies by Barbier, Ann J., Jiang, Allen Yujie, Zhang, Peng, Wooster, Richard, Anderson, Daniel G.

“…The emergency use authorizations (EUAs) of two mRNA-based severe acute respiratory syndrome coronavirus (SARS-CoV)-2 vaccines approximately 11 months after…”
Get full text

Materials for non-viral intracellular delivery of messenger RNA therapeutics by Kauffman, Kevin J., Webber, Matthew J., Anderson, Daniel G.

“…Though therapeutics based on messenger RNA (mRNA) have broad potential in applications such as protein replacement therapy, cancer immunotherapy, and genomic…”
Get full text

Advances in the delivery of RNA therapeutics: from concept to clinical reality by Kaczmarek, James C, Kowalski, Piotr S, Anderson, Daniel G

“…The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic…”
Get full text

Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications by England, Bryant R, Thiele, Geoffrey M, Anderson, Daniel R, Mikuls, Ted R

“…ABSTRACTRheumatoid arthritis is a systemic autoimmune disease characterized by excess morbidity and mortality from cardiovascular disease. Mechanisms linking…”
Get full text

Bio-Inspired Polymer Composite Actuator and Generator Driven by Water Gradients by Ma, Mingming, Guo, Liang, Anderson, Daniel G., Langer, Robert

“…Here we describe the development of a water-responsive polymer film. Combining both a rigid matrix (polypyrrole) and a dynamic network (polyol-borate), strong…”
Get full text

CRISPR–Cas: a tool for cancer research and therapeutics by Yin, Hao, Xue, Wen, Anderson, Daniel G.

“…In the past decade, the development of a genome-editing technology mediated by CRISPR has made genetic engineering easier than ever, both in vitro and in vivo…”
Get full text

Biomaterials for Personalized Cell Therapy by Facklam, Amanda L., Volpatti, Lisa R., Anderson, Daniel G.

“…Cell therapy has already had an important impact on healthcare and provided new treatments for previously intractable diseases. Notable examples include…”
Get full text

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling by Platt, Randall J., Chen, Sidi, Zhou, Yang, Yim, Michael J., Swiech, Lukasz, Kempton, Hannah R., Dahlman, James E., Parnas, Oren, Eisenhaure, Thomas M., Jovanovic, Marko, Graham, Daniel B., Jhunjhunwala, Siddharth, Heidenreich, Matthias, Xavier, Ramnik J., Langer, Robert, Anderson, Daniel G., Hacohen, Nir, Regev, Aviv, Feng, Guoping, Sharp, Phillip A., Zhang, Feng

“…CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we…”
Get full text

Knocking down barriers: advances in siRNA delivery by Anderson, Daniel G, Whitehead, Kathryn A, Langer, Robert

“…Key Points RNA interference (RNAi) is a fundamental pathway in eukaryotic cells by which sequence-specific small interfering RNA (siRNA) is able to silence…”
Get full text

mRNA therapeutics: beyond vaccine applications by Bhat, Balkrishen, Karve, Shrirang, Anderson, Daniel G.

Get full text

Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties by Yesilyurt, Volkan, Webber, Matthew J., Appel, Eric A., Godwin, Colin, Langer, Robert, Anderson, Daniel G.

“…Dynamically restructuring pH‐responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis‐diol modified…”
Get full text

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation by Miao, Lei, Li, Linxian, Huang, Yuxuan, Delcassian, Derfogail, Chahal, Jasdave, Han, Jinsong, Shi, Yunhua, Sadtler, Kaitlyn, Gao, Wenting, Lin, Jiaqi, Doloff, Joshua C., Langer, Robert, Anderson, Daniel G.

“…Therapeutic messenger RNA vaccines enable delivery of whole antigens, which can be advantageous over peptide vaccines. However, optimal efficacy requires both…”
Get full text

Nanoparticle-based drug delivery systems: a commercial and regulatory outlook as the field matures by Ragelle, Héloïse, Danhier, Fabienne, Préat, Véronique, Langer, Robert, Anderson, Daniel G

“…Nanomedicine has emerged as a major field of academic research with direct impact on human health. While a first generation of products has been successfully…”
Get more information