Search Results - "Anderson, Christen M"

Randomized Placebo‐Controlled Clinical Trial of Lorcaserin for Weight Loss in Type 2 Diabetes Mellitus: The BLOOM‐DM Study by O'Neil, Patrick M., Smith, Steven R., Weissman, Neil J., Fidler, Meredith C., Sanchez, Matilde, Zhang, Jinkun, Raether, Brian, Anderson, Christen M., Shanahan, William R.

“…The BLOOM‐DM (Behavioral Modification and Lorcaserin for Obesity and Overweight Management in Diabetes Mellitus) study evaluated efficacy and safety of…”
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A One-Year Randomized Trial of Lorcaserin for Weight Loss in Obese and Overweight Adults: The BLOSSOM Trial by Fidler, Meredith C, Sanchez, Matilde, Raether, Brian, Weissman, Neil J, Smith, Steven R, Shanahan, William R, Anderson, Christen M

“…Context: Lorcaserin is a novel selective agonist of the serotonin 2C receptor. Objective: Our objective was to evaluate the effects of lorcaserin on body…”
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Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies by Roth, Jonathan D, Roland, Barbara L, Cole, Rebecca L, Trevaskis, James L, Weyer, Christian, Koda, Joy E, Anderson, Christen M, Parkes, David G, Baron, Alain D

“…Body weight is regulated by complex neurohormonal interactions between endocrine signals of long-term adiposity (e.g., leptin, a hypothalamic signal) and…”
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Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management by SMITH, Steven R, WEISSMAN, Neil J, ANDERSON, Christen M, SANCHEZ, Matilde, CHUANG, Emil, STUBBE, Scott, BAYS, Harold, SHANAHAN, William R, MODIFICATION, Behavioral

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Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management by Smith, Steven R, Weissman, Neil J, Anderson, Christen M, Sanchez, Matilde, Chuang, Emil, Stubbe, Scott, Bays, Harold, Shanahan, William R

“…In this trial, obese or overweight adults were randomly assigned to receive the selective serotonin 2C receptor agonist lorcaserin or placebo for 52 weeks,…”
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Lorcaserin, A 5-HT2C Receptor Agonist, Reduces Body Weight by Decreasing Energy Intake without Influencing Energy Expenditure by Martin, Corby K, Redman, Leanne M, Zhang, Jinkun, Sanchez, Matilde, Anderson, Christen M, Smith, Steven R, Ravussin, Eric

“…Lorcaserin, a selective 5-HT2C receptor agonist, reduces body weight through its effects on food intake and appetite, not energy expenditure or substrate…”
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Inhibition of Mitochondrial Na+-Ca2+ Exchanger Increases Mitochondrial Metabolism and Potentiates Glucose-Stimulated Insulin Secretion in Rat Pancreatic Islets by LEE, Bumsup, MILES, Philip D, OLEFSKY, Jerrold M, ANDERSON, Christen M, VARGAS, Leonardo, PENG LUAN, GLASCO, Susan, KUSHNAREVA, Yulia, KORNBRUST, Elisabeth S, GRAKO, Kathryn A, WOLLHEIM, Claes B, MAECHLER, Pierre

“…Inhibition of Mitochondrial Na + -Ca 2+ Exchanger Increases Mitochondrial Metabolism and Potentiates Glucose-Stimulated Insulin Secretion in Rat Pancreatic…”
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Biological activity of AC3174, a peptide analog of exendin-4 by Hargrove, Diane M., Kendall, Eric S., Reynolds, James M., Lwin, Aung N., Herich, John P., Smith, Pamela A., Gedulin, Bronislava R., Flanagan, Shawn D., Jodka, Carolyn M., Hoyt, Julie A., McCowen, Kevin M., Parkes, David G., Anderson, Christen M.

“…Exenatide, the active ingredient of BYETTA® (exenatide injection), is an incretin mimetic that has been developed for the treatment of patients with type 2…”
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Lorcaserin (APD356), a Selective 5‐HT2C Agonist, Reduces Body Weight in Obese Men and Women by Smith, Steven R., Prosser, Warren A., Donahue, David J., Morgan, Michael E., Anderson, Christen M., Shanahan, William R.

“…Lorcaserin (APD356) is a potent, selective 5‐HT2C agonist with ∼15‐fold and 100‐fold selectivity vs. 5‐HT2A and 5‐HT2B receptors, respectively. This study…”
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Antiobesity Effects of the β-Cell Hormone Amylin in Diet-Induced Obese Rats: Effects on Food Intake, Body Weight, Composition, Energy Expenditure, and Gene Expression by Roth, Jonathan D, Hughes, Heather, Kendall, Eric, Baron, Alain D, Anderson, Christen M

“…Effects of amylin and pair feeding (PF) on body weight and metabolic parameters were characterized in diet-induced obesity-prone rats. Peripherally…”
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Echocardiographic assessment of cardiac valvular regurgitation with lorcaserin from analysis of 3 phase 3 clinical trials by Weissman, Neil J, Sanchez, Matilde, Koch, Gary G, Smith, Steven R, Shanahan, William R, Anderson, Christen M

“…Lorcaserin is a selective 5-HT2C agonist evaluated for weight management in clinical trials. Echocardiographic monitoring was conducted to test the hypothesis…”
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Efficient Syntheses of Benzothiazepines as Antagonists for the Mitochondrial Sodium−Calcium Exchanger:  Potential Therapeutics for Type II Diabetes by Pei, Yazhong, Lilly, Michael J, Owen, David J, D'Souza, Lawrence J, Tang, Xiao-Qing, Yu, Jinghua, Nazarbaghi, Ramina, Hunter, Andrew, Anderson, Christen M, Glasco, Susan, Ede, Nicholas J, James, Ian W, Maitra, Uday, Chandrasekaran, S, Moos, Walter H, Ghosh, Soumitra S

“…Type II diabetes mellitus is a chronic metabolic disorder that can lead to serious cardiovascular, renal, neurologic, and retinal complications. While several…”
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Effects of prior or concurrent food restriction on amylin-induced changes in body weight and body composition in high-fat-fed female rats by Roth, Jonathan D, Hughes, Heather, Coffey, Todd, Maier, Holly, Trevaskis, James L, Anderson, Christen M

“…Amylin infusion reduces food intake and slows body weight gain in rodents. In obese male rats, amylin (but not pair feeding) caused a preferential reduction of…”
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Lorcaserin (APD356), a Selective 5‐HT 2C Agonist, Reduces Body Weight in Obese Men and Women by Smith, Steven R., Prosser, Warren A., Donahue, David J., Morgan, Michael E., Anderson, Christen M., Shanahan, William R.

“…Lorcaserin (APD356) is a potent, selective 5‐HT 2C agonist with ∼15‐fold and 100‐fold selectivity vs. 5‐HT 2A and 5‐HT 2B receptors, respectively. This study…”
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Lorcaserin, A 5-HT 2C Receptor Agonist, Reduces Body Weight by Decreasing Energy Intake without Influencing Energy Expenditure by Martin, Corby K., Redman, Leanne M., Zhang, Jinkun, Sanchez, Matilde, Anderson, Christen M., Smith, Steven R., Ravussin, Eric

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Inhibition of mitochondrial Na(+) -Ca(2+) exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets by Lee, Bumsup, Miles, Philip D, Vargas, Leonardo, Peng Luan

“…The mitochondrial Na(+)-Ca(2+) exchanger (mNCE) mediates efflux of Ca(2+) from mitochondria in exchange for influx of Na(+). We show that inhibition of the…”
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Lorcaserin (APD356), a Selective 5-HT Agonist, Reduces Body Weight in Obese Men and Women by Smith, Steven R, Prosser, Warren A, Donahue, David J, Morgan, Michael E, Anderson, Christen M, Shanahan, William R

“…Lorcaserin (APD356) is a potent, selective 5-HT(2C) agonist with ~15-fold and 100-fold selectivity vs. 5-HT(2A) and 5-HT(2B) receptors, respectively. This…”
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Regulation of steroidogenesis in rat Leydig cells in culture: effect of human chorionic gonadotropin and dibutyryl cyclic AMP on the synthesis of cholesterol side chain cleavage cytochrome P-450 and adrenodoxin by Anderson, C M, Mendelson, C R

“…Rat Leydig cells in primary culture were used as a model system to investigate the effects of human chorionic gonadotropin (hCG) and dibutyryl cyclic AMP…”
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Pharmacokinetics and Tolerability of Lorcaserin in Special Populations: Elderly Patients and Patients with Renal or Hepatic Impairment by Christopher, Ronald J., PhD, DABT, Morgan, Michael E, Tang, Yong, Anderson, Christen, MD, PhD, Sanchez, Matilde, Shanahan, William

“…Abstract Purpose To determine whether dosage adjustment is likely to be necessary for effective and well-tolerated use of a pharmaceutical agent, guidance…”
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Antiobesity Effects of the {szligbeta}-Cell Hormone Amylin in Diet-Induced Obese Rats: Effects on Food Intake, Body Weight, Composition, Energy Expenditure, and Gene Expression by Roth, Jonathan D, Hughes, Heather, Kendall, Eric, Baron, Alain D, Anderson, Christen M

“…Effects of amylin and pair feeding (PF) on body weight and metabolic parameters were characterized in diet-induced obesity-prone rats. Peripherally…”
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