Search Results - "Anderson, Brooke A"

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides by Anderson, Brooke A, Freestone, Graeme C, Low, Audrey, De-Hoyos, Cheryl L, III, William J Drury, Østergaard, Michael E, Migawa, Michael T, Fazio, Michael, Wan, W Brad, Berdeja, Andres, Scandalis, Eli, Burel, Sebastien A, Vickers, Timothy A, Crooke, Stanley T, Swayze, Eric E, Liang, Xuehai, Seth, Punit P

“…Abstract The PS modification enhances the nuclease stability and protein binding properties of gapmer antisense oligonucleotides (ASOs) and is one of very few…”
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Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins by Hyjek-Składanowska, Malwina, Vickers, Timothy A, Napiórkowska, Agnieszka, Anderson, Brooke A, Tanowitz, Michael, Crooke, Stanley T, Liang, Xue-hai, Seth, Punit P, Nowotny, Marcin

“…The phosphorothioate backbone modification (PS) is one of the most widely used chemical modifications for enhancing the drug-like properties of nucleic…”
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Optimization of Replication, Transcription, and Translation in a Semi-Synthetic Organism by Feldman, Aaron W, Dien, Vivian T, Karadeema, Rebekah J, Fischer, Emil C, You, Yanbo, Anderson, Brooke A, Krishnamurthy, Ramanarayanan, Chen, Jason S, Li, Lingjun, Romesberg, Floyd E

“…Previously, we reported the creation of a semi-synthetic organism (SSO) that stores and retrieves increased information by virtue of stably maintaining an…”
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Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics by Finicle, Brendan T, Eckenstein, Kazumi H, Revenko, Alexey S, Anderson, Brooke A, Wan, W Brad, McCracken, Alison N, Gil, Daniel, Fruman, David A, Hanessian, Stephen, Seth, Punit P, Edinger, Aimee L

“…Inefficient endosomal escape remains the primary barrier to the broad application of oligonucleotide therapeutics. Liver uptake after systemic administration…”
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Merging Two Strategies for Mixed-Sequence Recognition of Double-Stranded DNA: Pseudocomplementary Invader Probes by Anderson, Brooke A, Hrdlicka, Patrick J

“…The development of molecular strategies that enable recognition of specific double-stranded DNA (dsDNA) regions has been a longstanding goal as evidenced by…”
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Invader probes: Harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications by Guenther, Dale C, Anderson, Grace H, Karmakar, Saswata, Anderson, Brooke A, Didion, Bradley A, Guo, Wei, Verstegen, John P, Hrdlicka, Patrick J

“…Development of probes capable of recognizing specific regions of chromosomal DNA has been a long-standing goal for chemical biologists. Current strategies such…”
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Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid) by Kumar, Pawan, Østergaard, Michael E, Baral, Bharat, Anderson, Brooke A, Guenther, Dale C, Kaura, Mamta, Raible, Daniel J, Sharma, Pawan K, Hrdlicka, Patrick J

“…Oligonucleotides modified with conformationally restricted nucleotides such as locked nucleic acid (LNA) monomers are used extensively in molecular biology and…”
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C5-amino acid functionalized LNA: positively poised for antisense applications by Guenther, Dale C, Kumar, Pawan, Anderson, Brooke A, Hrdlicka, Patrick J

“…Incorporation of positively charged C5-amino acid functionalized LNA uridines into oligodeoxyribonucleotides (ONs) results in extraordinary RNA affinity,…”
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Mixed-Sequence Recognition of Double-Stranded DNA Using Enzymatically Stable Phosphorothioate Invader Probes by Anderson, Brooke A, Karmakar, Saswata, Hrdlicka, Patrick J

“…Development of probes that allow for sequence-unrestricted recognition of double-stranded DNA (dsDNA) continues to attract much attention due to the prospect…”
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Identification and Characterization of Second-Generation Invader Locked Nucleic Acids (LNAs) for Mixed-Sequence Recognition of Double-Stranded DNA by Sau, Sujay P, Madsen, Andreas S, Podbevsek, Peter, Andersen, Nicolai K, Kumar, T. Santhosh, Andersen, Sanne, Rathje, Rie L, Anderson, Brooke A, Guenther, Dale C, Karmakar, Saswata, Kumar, Pawan, Plavec, Janez, Wengel, Jesper, Hrdlicka, Patrick J

“…The development of synthetic agents that recognize double-stranded DNA (dsDNA) is a long-standing goal that is inspired by the promise for tools that detect,…”
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Heterogeneous Pyrophosphate‐Linked DNA–Oligonucleotides: Aversion to DNA but Affinity for RNA by Anderson, Brooke A., Krishnamurthy, Ramanarayanan

“…Pyrophosphate linkages are important in extant biology and are hypothesized to have played a role in prebiotic chemistry and in the origination of…”
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Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA by Sau, Sujay P, Kumar, Pawan, Anderson, Brooke A, Østergaard, Michael E, Deobald, Lee, Paszczynski, Andrzej, Sharma, Pawan K, Hrdlicka, Patrick J

“…Triplex forming oligonucleotides (TFOs) modified with C5-alkynyl functionalized LNA (locked nucleic acid) monomers display extraordinary thermal affinity…”
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The Unexpected Base‐Pairing Behavior of Cyanuric Acid in RNA and Ribose versus Cyanuric Acid Induced Helicene Assembly of Nucleic Acids: Implications for the Pre‐RNA Paradigm by Anderson, Brooke A., Fauché, Kévin, Karunakaran, Suneesh C., Yerabolu, Jayasudhan R., Hud, Nicholas V., Krishnamurthy, Ramanarayanan

“…The cyanuric acid (CA) heterocycle forms supramolecular structures with adenine nucleobases/nucleosides and oligonucleotides, leading to speculation that they…”
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Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding by Hyjek-Składanowska, Malwina, Anderson, Brooke A, Mykhaylyk, Vitaliy, Orr, Christian, Wagner, Armin, Poznański, Jarosław T, Skowronek, Krzysztof, Seth, Punit, Nowotny, Marcin

“…The introduction of phosphorothioate (PS) linkages to the backbone of therapeutic nucleic acids substantially increases their stability and potency. It also…”
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Frontispiece: The Unexpected Base‐Pairing Behavior of Cyanuric Acid in RNA and Ribose versus Cyanuric Acid Induced Helicene Assembly of Nucleic Acids: Implications for the Pre‐RNA Paradigm by Anderson, Brooke A., Fauché, Kévin, Karunakaran, Suneesh C., Yerabolu, Jayasudhan R., Hud, Nicholas V., Krishnamurthy, Ramanarayanan

“…Elementary my dear Helicene: An old‐school plastic molecular model of the supramolecular assembly formed by poly‐adenosine with cyanuric acid reveals a…”
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C5-Functionalized LNA: Unparalleled Hybridization Properties and Enzymatic Stability by Østergaard, Michael E, Kumar, Pawan, Baral, Bharat, Raible, Daniel J, Santhosh Kumar, T, Anderson, Brooke A, Guenther, Dale C, Deobald, Lee, Paszczynski, Andrzej J, Sharma, Pawan K, Hrdlicka, Patrick J

“…The best of both worlds: C5‐functionalized locked nucleic acids (LNAs) synergistically combine the beneficial features of C5‐alkynyl DNAs and conventional…”
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Nanopore Sequencing of an Expanded Genetic Alphabet Reveals High-Fidelity Replication of a Predominantly Hydrophobic Unnatural Base Pair by Ledbetter, Michael P, Craig, Jonathan M, Karadeema, Rebekah J, Noakes, Matthew T, Kim, Hwanhee C, Abell, Sarah J, Huang, Jesse R, Anderson, Brooke A, Krishnamurthy, Ramanarayanan, Gundlach, Jens H, Romesberg, Floyd E

“…Unnatural base pairs (UBPs) have been developed and used for a variety of in vitro applications as well as for the engineering of semisynthetic organisms…”
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Recognition of Double-Stranded DNA Using Energetically Activated Duplexes Modified with N2′-Pyrene‑, Perylene‑, or Coronene-Functionalized 2′‑N‑Methyl-2′-amino-DNA Monomers by Anderson, Brooke A, Onley, Jared J, Hrdlicka, Patrick J

“…Invader probes have been proposed as alternatives to polyamides, triplex-forming oligonucleotides, and peptide nucleic acids for recognition of chromosomal DNA…”
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Synthesis and characterization of oligodeoxyribonucleotides modified with 2′-thio-2′-deoxy-2′-S-(pyren-1-yl)methyluridine by Anderson, Brooke A., Hrdlicka, Patrick J.

“…[Display omitted] Pyrene-functionalized oligonucleotides are intensively explored for applications in materials science and diagnostics. Here, we describe a…”
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Synthesis and Characterization of Oligodeoxyribonucleotides Modified with 2′-Amino-α‑l‑LNA Adenine Monomers: High-Affinity Targeting of Single-Stranded DNA by Andersen, Nicolai K, Anderson, Brooke A, Wengel, Jesper, Hrdlicka, Patrick J

“…The development of conformationally restricted nucleotide building blocks continues to attract considerable interest because of their successful use within…”
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