Search Results - "Anderson, Alexander"

Integrative mathematical oncology by Anderson, Alexander R. A, Quaranta, Vito

“…Cancer research attracts broad resources and scientists from many disciplines, and has produced some impressive advances in the treatment and understanding of…”
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NeoPredPipe: high-throughput neoantigen prediction and recognition potential pipeline by Schenck, Ryan O, Lakatos, Eszter, Gatenbee, Chandler, Graham, Trevor A, Anderson, Alexander R A

“…Next generation sequencing has yielded an unparalleled means of quickly determining the molecular make-up of patient tumors. In conjunction with emerging,…”
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Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow by Gillies, Robert J., Brown, Joel S., Anderson, Alexander R. A., Gatenby, Robert A.

“…Temporal changes in blood flow are commonly observed in malignant tumours, but the evolutionary causes and consequences are rarely considered. We propose that…”
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Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes by Robertson-Tessi, Mark, Gillies, Robert J, Gatenby, Robert A, Anderson, Alexander R A

“…Histopathologic knowledge that extensive heterogeneity exists between and within tumors has been confirmed and deepened recently by molecular studies. However,…”
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Agent-based methods facilitate integrative science in cancer by West, Jeffrey, Robertson-Tessi, Mark, Anderson, Alexander R.A.

“…In this opinion, we highlight agent-based modeling as a key tool for exploration of cell–cell and cell–environment interactions that drive cancer progression,…”
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Classifying the evolutionary and ecological features of neoplasms by Maley, Carlo C., Aktipis, Athena, Graham, Trevor A., Sottoriva, Andrea, Boddy, Amy M., Janiszewska, Michalina, Silva, Ariosto S., Gerlinger, Marco, Yuan, Yinyin, Pienta, Kenneth J., Anderson, Karen S., Gatenby, Robert, Swanton, Charles, Posada, David, Wu, Chung-I, Schiffman, Joshua D., Hwang, E. Shelley, Polyak, Kornelia, Anderson, Alexander R. A., Brown, Joel S., Greaves, Mel, Shibata, Darryl

“…Based on a consensus conference of experts in the evolution and ecology of cancer, this article proposes a framework for classifying tumours that includes four…”
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The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer by Gallaher, Jill A., Brown, Joel S., Anderson, Alexander R. A.

“…Tumors are not static masses of cells but dynamic ecosystems where cancer cells experience constant turnover and evolve fitness-enhancing phenotypes. Selection…”
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Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies by Gallaher, Jill A, Enriquez-Navas, Pedro M, Luddy, Kimberly A, Gatenby, Robert A, Anderson, Alexander R A

“…Treatment of advanced cancers has benefited from new agents that supplement or bypass conventional therapies. However, even effective therapies fail as cancer…”
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Antibiotic collateral sensitivity is contingent on the repeatability of evolution by Nichol, Daniel, Rutter, Joseph, Bryant, Christopher, Hujer, Andrea M., Lek, Sai, Adams, Mark D., Jeavons, Peter, Anderson, Alexander R. A., Bonomo, Robert A., Scott, Jacob G.

“…Antibiotic resistance represents a growing health crisis that necessitates the immediate discovery of novel treatment strategies. One such strategy is the…”
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Hybrid Automata Library: A flexible platform for hybrid modeling with real-time visualization by Bravo, Rafael R, Baratchart, Etienne, West, Jeffrey, Schenck, Ryan O, Miller, Anna K, Gallaher, Jill, Gatenbee, Chandler D, Basanta, David, Robertson-Tessi, Mark, Anderson, Alexander R A

“…The Hybrid Automata Library (HAL) is a Java Library developed for use in mathematical oncology modeling. It is made of simple, efficient, generic components…”
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Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance by Nichol, Daniel, Jeavons, Peter, Fletcher, Alexander G, Bonomo, Robert A, Maini, Philip K, Paul, Jerome L, Gatenby, Robert A, Anderson, Alexander R A, Scott, Jacob G

“…The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments presents a growing threat to public health. Here, we consider…”
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Normal tissue architecture determines the evolutionary course of cancer by West, Jeffrey, Schenck, Ryan O., Gatenbee, Chandler, Robertson-Tessi, Mark, Anderson, Alexander R. A.

“…Cancer growth can be described as a caricature of the renewal process of the tissue of origin, where the tissue architecture has a strong influence on the…”
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Towards Multidrug Adaptive Therapy by West, Jeffrey, You, Li, Zhang, Jingsong, Gatenby, Robert A, Brown, Joel S, Newton, Paul K, Anderson, Alexander R A

“…A new ecologically inspired paradigm in cancer treatment known as "adaptive therapy" capitalizes on competitive interactions between drug-sensitive and…”
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Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment by Anderson, Alexander R.A., Weaver, Alissa M., Cummings, Peter T., Quaranta, Vito

“…Emergence of invasive behavior in cancer is life-threatening, yet ill-defined due to its multifactorial nature. We present a multiscale mathematical model of…”
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Mathematical Model-Driven Deep Learning Enables Personalized Adaptive Therapy by Gallagher, Kit, Strobl, Maximilian A, Park, Derek S, Spoendlin, Fabian C, Gatenby, Robert A, Maini, Philip K, Anderson, Alexander R

“…Standard-of-care treatment regimens have long been designed for maximal cell killing, yet these strategies often fail when applied to metastatic cancers due to…”
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Cell signaling heterogeneity is modulated by both cell-intrinsic and -extrinsic mechanisms: An integrated approach to understanding targeted therapy by Kim, Eunjung, Kim, Jae-Young, Smith, Matthew A, Haura, Eric B, Anderson, Alexander R A

“…During the last decade, our understanding of cancer cell signaling networks has significantly improved, leading to the development of various targeted…”
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Mitochondrial protein import dysfunction: mitochondrial disease, neurodegenerative disease and cancer by Palmer, Catherine S., Anderson, Alexander J., Stojanovski, Diana

“…The majority of proteins localised to mitochondria are encoded by the nuclear genome, with approximately 1500 proteins imported into mammalian mitochondria…”
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From cells to tissue: How cell scale heterogeneity impacts glioblastoma growth and treatment response by Gallaher, Jill A, Massey, Susan C, Hawkins-Daarud, Andrea, Noticewala, Sonal S, Rockne, Russell C, Johnston, Sandra K, Gonzalez-Cuyar, Luis, Juliano, Joseph, Gil, Orlando, Swanson, Kristin R, Canoll, Peter, Anderson, Alexander R A

“…Glioblastomas are aggressive primary brain tumors known for their inter- and intratumor heterogeneity. This disease is uniformly fatal, with intratumor…”
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PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression by PARAISO, Kim H. T, YUN XIANG, RIBAS, Antoni, DALLA PALMA, Maurizia, NATHANSON, Katherine L, KOOMEN, John M, MESSINA, Jane L, SMALLEY, Keiran S. M, REBECCA, Vito W, ABEL, Ethan V, CHEN, Y. Ann, MUNKO, A. Cecilia, WOOD, Elizabeth, FEDORENKO, Inna V, SONDAK, Vernon K, ANDERSON, Alexander R. A

“…This study addresses the role of PTEN loss in intrinsic resistance to the BRAF inhibitor PLX4720. Immunohistochemical staining of a tissue array covering all…”
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The role of memory in non-genetic inheritance and its impact on cancer treatment resistance by Cassidy, Tyler, Nichol, Daniel, Robertson-Tessi, Mark, Craig, Morgan, Anderson, Alexander R A

“…Intra-tumour heterogeneity is a leading cause of treatment failure and disease progression in cancer. While genetic mutations have long been accepted as a…”
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